Reconstruction of paleohydraulic conditions of deposition of the Upper Permian strata of the Kama region

Paleohydraulic sedimentary conditions of the Upper Permian basin the East European platform region were reconstructed based on the data of grain size and structural analyses of the strata. Calculation of the paleolithodynamic parameters indicated that real duration of the sedimentation of the strata was much less than corresponding interval on the stratigraphic time-scale. Similar ratios are typical for other sedimentary formations in both platform and folded geological areas that correspond to an injective type of sedimentogenesis. This regularity should be taken into account in the interpretation of the stratigraphic chart and forecasting of sedimentary mineral deposits (hydrocarbon, in the first place)

Effects of Homocysteine and its Derivatives on Spontaneous Network Activity in the Hippocampus of Neonatal Rat Pups

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Homocysteine is a sulfur-containing amino acid, which at high concentrations has neurotoxic effects and induces impairments to the development of the nervous system. Homocysteine is rapidly oxidized in the plasma, forming disulfide bonds with proteins and other low molecular weight thiols; it also undergoes transformation into the into homocysteine thiolactone. On chronic exposure, the neurotoxicity of homocysteine is therefore mediated mainly by its derivatives. The aim of the present work was to investigate the effects of homocysteine and its derivatives – homocystine and homocysteine thiolactone – on spontaneous network activity in the hippocampus of rats in the first week after birth. Giant depolarizing potentials (GDP) and multiple action potentials (MAP) were recorded using an extracellular electrode in hippocampal field CA3. All three study compounds were found to induce increases in the frequency of GDP and MAP at concentrations of 100 and 500 μM, homocystine producing the most significant increase in neuron network activity. The effects of homocysteine, homocystine, and homocysteine thiolactone on the spontaneous network activity of neurons were completely eliminated on blockade of NMDA and AMPA receptors. Thus, homocysteine and its derivatives lead to increased spontaneous network activity of hippocampal neurons in neonatal rats, which can induce impairments to the formation of the neural networks of the hippocampus in conditions of chronic hyperhomocysteinemia, and could also induce hyperexcitability and the risk of developing epilepsy in the postnatal period

Risk factors in the backbone public health protection complex

© by University of Guilan, Printed in I.R. Iran. The current stage of Russian society development in the conditions of recent socio-economic formation is characterized by a surge of interest and the number of scientific studies devoted to the assessment of environmental factors and the construction of eco-dependent pathology. A region of the Russian Federation with a developed industry was taken as the study area. In particular, indicators of environmental pollution factors, as well as indicators of population morbidity, were studied. The studies were carried out over time for 2013-2018. To assess the risk, the multimedia exposure risk calculating method was used. The hazard index was also evaluated; it characterizes the disturbances of a particular body system. Analysis of the data on the qualitative and quantitative composition of the water basin of the given territory allowed us to conclude that the level of indicators of iron, fluoride, and nitrite compounds, dry residue and water pH practically did not change over time. The concentration of nitrates, total hardness, ammonium salts, BOD5, sulphate’s, and chlorides increased significantly, while dissolved oxygen decreased. Data on the prevalence and primary morbidity among the population indicate that the prevalence and primary incidence rates in the study area are characterized by uneven indicators, which made it possible to rank and establish statistically significant differences in the studied indicators. Data analysis using the methods of parametric and nonparametric statistics made it possible to confirm that the levels of chlorine derivatives, dissolved oxygen, and total hardness significantly affect the formation of the incidence rate of the population in the studied region. The calculated values of carcinogenic risks with the cutaneous intake of cadmium are 2.0 ×10-8. The values of carcinogenic risks for oral intake of cadmium are 0.3 ×10-6. It was found that the Deminimis level in the total carcinogenic risk level is 0.6% for the study area

Population health indicators under conditions of environmental risk intermitting

© by University of Guilan, Printed in I.R. Iran. The modern stage of development of our society is characterized by close attention to the problems of demography. The relevance of information on the population and the thoroughness of its analysis has increased to develop an effective demographic policy. Analysis of the demographic situation in the constituent entities of Russia is necessary for making decisions in the economic and social spheres, for planning and forecasting the development of our society. These indicators are directly related to the growth rate of labour resources. Comparison of the birth rate among the urban and rural population of the constituent entity of the Russian Federation showed the following results. In 1991-2002, the birth rate of the rural population exceeded the birth rate of the urban population by an average of 1.8 per 1000 people. However, since 2003 the situation has changed to the opposite, with an increasing trend for both urban and rural populations. At the same time, over the past 5 years, the birth rate of the urban and rural population has begun to decline, amounting to 13.5 and 8.8 per 1000 people in 2017, respectively (P < 0.05). Having analyzed the relevant data in a timely manner, it is possible to influence the situation in the required direction using social, economic and political tools to influence the demographic situation in the subject of the Russian Federation