Clinical and Immunological Assessment of Changes in the IgE Value in Patients with Papulo - Pustular Subtype of Rosacea Complicated by Demodecosis

Rosacea is a chronic multifactor dermatosis, realized by pathological reaction of blood vessels under the influence of vasoactive peptides, antibodies, circulating immune complexes and characterized by recurrent course, stages and manifested by hyperemia of the face, papules, pustules, telangioectasia, hyperplasia of the sebaceous glands and connective tissue [1]. A key role in the pathogenesis of rosacea plays a cutaneous inflammatory process. Inflammation is initiated with the participation of TLR2 (Toll-like receptor, toll-like receptors) keratinocytes. These transmembrane structures can be activated by physical factors (UFO, high and low temperatures), a number of antigens (chitin shell D. folliculorum, glycoproteins B. Oleronius; in dermal infiltrates in the area of lesions found T-lymphocytes sensitized to antigens D. folliculorum), neuropeptides during stress (neuroimmune mechanisms) or the formation of viscerocutaneous reflexes. Further development of inflammation due to the secretion by the keratinocytes of inflammatory proteases (matrix metalloproteinases, kallikreins) and antimicrobial peptides (alpha-, betadefensins and cathelicidin LL-37). Currently, it is the cathelicidin LL-37 plays a significant role in the development of rosacea. This antimicrobial polypeptide, consisting of 37 amino acids, belongs to the family kallikrein-kinin. Its level in the affected skin is significantly increased in all subtypes of rosacea. Products LL-37 is enhanced by the influence of UFO (due to the synthesis of vitamin D), high and low temperatures, infectious agents. Intradermal injections of LL-37 cause the development of dermatitis clinically similar to rosacea in experimental animals [2]

Clinical efficacy evaluation of a multivitamin combined reparative drug for local use in the complex therapy of eczema

Problem relevance. The share increase of eczema in the structure of dermatological pathology is steadily progressive. The largest number of patients is people of working age and there is a tendency to an increase in the severity of the pathological process and a decrease in the in-ter-relapse period with an increase in the length of the disease. Long-term remission is believed to optimize the pathology course and improve the patient’s life quality with eczema. Objective. To evaluate the effectiveness of multivitamin combined reparative ointment in the complex therapy of true eczema. Material and methods. The effect of multivitamin combined reparative ointment on the duration of the inter-relapse period was studied in 80 patients with chronic true eczema at the age of 25—55 years. Results. In patients of the main group, an increase in the duration of remission was observed on average up to 4 months a decrease in the severity of the clinical picture with a subsequent exacerbation and decrease in the indicators of the dermatological quality of life index. In ad-dition, in patients who used multivitamin combined reparative ointment during remission the condition of the skin improved; there were no se-rious side-effects. Conclusion. The use of multivitamin combined reparative ointment in the inter-relapse period of eczema reduces the severity of subjective and objective manifestations of the eczematous process. © 2021, Media Sphera Publishing Group. All rights reserved

Влияние общей анестезии при аденотомии и тонзиллотомии на когнитивные функции у детей

Background. Surgery under general anesthesia can affect the patients neurocognitive outcome. This problem is of particular relevance in pediatric surgical practice. Goal. The aim of this study is to determine the spectrum of clinical manifestations and the frequency of cognitive dysfunction symptom development in children after adenotomy and/or tonsillotomy performed under general anesthesia. Methods. This prospective study included 30 children aged 3 7 years (average age 4.9 1.3 years) who underwent adenotomy and/or tonsillotomy under general, combined, balanced anesthesia. In the preoperative period and a day after the operation, neuropsychological testing was performed: The Raven test, mechanical and associative memory test, Mini-Mental State Examination (MMSE) scale adapted for children from 3 years old, and the Bourdon test. A 20% decrease in function compared with the initial level was considered clinically significant. Results. One day after surgery, 10% of patients had a clinically significant decrease in attention productivity, 10% had a decrease in attention accuracy, 13.3% had a decrease in attention index, and 16.7% had a decrease in overall productivity and the attention index according to the Bourdon test. Also, 13.3% showed a decrease in attention, 30% had a decrease in memory on the MMSE scale, 20% showed a decrease in mechanical memory, and 10% had a decrease in test results on the Raven test. Conclusion. Conducting even minor surgical interventions with general anesthesia leads to an impairment of various cognitive functions in 10%30% of children aged 3 to 7 years.Введение. Выполненные в условиях общей анестезии хирургические вмешательства могут отрицательно влиять на нейрокогнитивные функции пациента. Особую актуальность данная проблема имеет в педиатрической хирургической практике. Цель. Определить характер и частоту развития симптомов когнитивной дисфункции у детей после адено- и/или тонзиллотомии, проведенных в условиях общей анестезии. Методы. В проспективное исследование включены 30 детей в возрасте 37 лет (средний возраст 4,9 1,3 года), которым выполняли операции аденотомии и/или тонзиллотомии в условиях общей анестезии. В предоперационном периоде и через сутки после операции проводили нейропсихологическое тестирование: матрицы Равена, тест на механическую и ассоциативную память, адаптированная для детей от 3 лет шкала MMSE и корректурные пробы. Клинически значимым считали уровень депрессии нейрокогнитивных функций относительно дооперационного уровня на 20 % и более. Результаты. Через одни сутки после хирургического вмешательства у 10 % пациентов было клинически значимое снижение продуктивности внимания, у 10 % точности внимания, 13,3 % устойчивости внимания, у 16,7 % снижение общего показателя продуктивности и устойчивости внимания по данным корректурных проб. По шкале MMSE регистрировали ухудшение памяти у 30 % детей, внимания у 13,3 %. У 20 % детей было отмечено снижение механической памяти. У 10 % снижение результатов тестирования матрицами Равена. Заключение. Проведение даже малых хирургических вмешательств в условиях общей анестезии приводит к нарушению различных когнитивных функций у 1030 % детей в возрасте 37 лет