14 research outputs found

    Polysaccharides Based Nanoparticles as Protein Oral Delivery System

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    Ovalbumin loaded chitosan and pectin based composite nanoparticles were obtained. The mean size, morphology and zeta potential of the nanoparticles were determined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Effect oral administration of obtained nanoparticles on the immune response was studied. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3548

    The history of the development of national traumatology on the example of medical and scientific activities of Saratov Research Institute of Traumatology and Orthopedics (SarNIITO) (1950-1980)

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    We outlined and described basic directions of national traumatology development at the period of 1950-1980 illustrated by the example of Saratov traumatological school, estimated the contribution of SarNIITO traumatologists into this development at the abovementioned period, depicted syna β€” one of the founders of acute trauma clinics.</p

    Аnaphylactic shock. Бlinical guidelines

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    Anaphylactic shock is a severe life-threatening condition caused by medicines, food, hymenoptera, animal poisons, etc. Therefore, anaphylactic shock (anaphylaxis) can develop both in medical institution and outside it, and physicians of any specialties should be ready to treat this condition. In this regard, clinical guidelines for anaphylactic shock have been developed. These recommendations were approved by the Russian Association of Allergy and Clinical Immunology (Protocol No. 743/12 dated December 30, 2020) and the Federation of Anesthesiologists and Resuscitators (Protocol No. 1 dated January 13, 2021), approved at a meeting of the Scientific and Practical Council of the Ministry of Health of the Russian Federation (Protocol No. 743/12 dated December 10, 2020). Guidelines covered a number of nosologies corresponding to codes of the International Statistical Classification of Diseases and Related Health Problems: T 78.0; T 78.2; T 80.5; T 88.6. The clinical guidelines systematize modern data on etiology, epidemiology, classification, clinical picture, diagnosis, treatment, and prevention of anaphylactic shock. In addition, an algorithm for managing a patient with anaphylactic shock has been developed. Clinical guidelines for anaphylactic shock are intended for practitioners of all specialties, students, and teachers of medical universities, residents, and graduate students

    ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Ρ„Π΅ΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ трансплантации Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΏΠΈΡ‰Π΅Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ‚Ρ€Π°ΠΊΡ‚Π° (ΠΏΠ΅Ρ€Π²Ρ‹ΠΉ клиничСский ΠΎΠΏΡ‹Ρ‚)

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    Materials and Methods: Following primary identification and typing of gut flora composition using microbiological, genetic and metabolomic methods, microbiota substrate pre-sampled from prepared healthy donors was administered to 30 patients with various GIT conditions (pseudomembranous Clostridium colitis, Colitis ulcerosa, Grohn's disease, irritable bowel syndrome, chronic fatigue syndrome). The efficiency of the procedure was determined on the basis of the clinical presentation, lab test results and comparison of microbiota condition prior to transplantation and at least at three points after transplantation - in 2 weeks, 1 and 3 months, using microbiological and metagenomic methods. Study Results: Following one procedure, all patients with antibiotic-associated Clostridium difficile colitis had remission and their normal microflora recovered. Patients with inflammatory GIT conditions had 1 to 2 procedures (depending on the process severity) in addition to their basic therapy, and the positive effect was recorded in all patients (remission, possible drug dose reduction). Conclusion: Faecal transplantation in various pathological GIT conditions demonstrated its perspective and huge therapeutic potential for Colitis ulcerosa, Grohn's disease, C. difficile-associated colitis, functional GIT conditions, metabolic disorders. The efficiency of endoscopic oral transplantation was higher as compared to rectal administration or lyophilized material in capsules.ЦСль исслСдования: ΠΏΠΎΠΊΠ°Π·Π°Ρ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ трансплантации ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Ρ‹ ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° ΠΏΡ€ΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… заболСваниях ΠΆΠ΅Π»ΡƒΠ΄ΠΎΡ‡Π½ΠΎ-ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΎΠ³ΠΎ Ρ‚Ρ€Π°ΠΊΡ‚Π° (Π–ΠšΠ’). Π”ΠΈΠ·Π°ΠΉΠ½: ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚ΠΎΠ΅ Π½Π΅ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ исслСдованиС. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ПослС ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½ΠΎΠΉ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ ΠΈ типирования состава ΠΌΠΈΠΊΡ€ΠΎΡ„Π»ΠΎΡ€Ρ‹ ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° с использованиСм микробиологичСских, гСнСтичСских ΠΈ ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΎΠΌΠ½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² субстрат ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Ρ‹, ΠΏΡ€Π΅Π΄Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Π·Π°Π±Ρ€Π°Π½Π½ΠΎΠΉ Ρƒ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²Π»Π΅Π½Π½Ρ‹Ρ… Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ½ΠΎΡ€ΠΎΠ², Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ 30 Π±ΠΎΠ»ΡŒΠ½Ρ‹ΠΌ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ заболСваниями Π–ΠšΠ’ (псСвдомСмбранозным клостридийным ΠΊΠΎΠ»ΠΈΡ‚ΠΎΠΌ, язвСнным ΠΊΠΎΠ»ΠΈΡ‚ΠΎΠΌ, болСзнью ΠšΡ€ΠΎΠ½Π°, синдромом Ρ€Π°Π·Π΄Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ°, синдромом хроничСской усталости). Π­Ρ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Ρ‹ опрСдСляли ΠΏΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ клиничСской ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρ‹, общСклиничСских Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ ΠΈ ΠΏΡƒΡ‚Π΅ΠΌ сравнСния состояния ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Ρ‹ Π΄ΠΎ пСрСсадки ΠΈ Π² ΠΌΠΈΠ½ΠΈΠΌΡƒΠΌ Ρ‚Ρ€Π΅Ρ… Ρ€Π΅ΠΏΠ΅Ρ€Π½Ρ‹Ρ… Ρ‚ΠΎΡ‡ΠΊΠ°Ρ… - Ρ‡Π΅Ρ€Π΅Π· 2 Π½Π΅Π΄Π΅Π»ΠΈ, 1 ΠΈ 3 мСсяца послС трансплантации, с использованиСм микробиологичСских ΠΈ ΠΌΠ΅Ρ‚Π°Π³Π΅Π½ΠΎΠΌΠ½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ². Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π£ всСх ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π°Π½Ρ‚ΠΈΠ±ΠΈΠΎΡ‚ΠΈΠΊΠΎ-ассоциированным Clostridium difficile-ΠΊΠΎΠ»ΠΈΡ‚ΠΎΠΌ послС ΠΎΠ΄Π½ΠΎΠΊΡ€Π°Ρ‚Π½ΠΎΠΉ ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Ρ‹ наступали рСмиссия ΠΈ восстановлСниС Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½ΠΎΠΉ ΠΌΠΈΠΊΡ€ΠΎΡ„Π»ΠΎΡ€Ρ‹. Π‘ΠΎΠ»ΡŒΠ½Ρ‹ΠΌ с Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌΠΈ заболСваниями ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° Π½Π° Ρ„ΠΎΠ½Π΅ Π±Π°Π·ΠΎΠ²ΠΎΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ ΠΎΡ‚ 1 Π΄ΠΎ 2 ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€ (Π² зависимости ΠΎΡ‚ стСпСни выраТСнности процСсса) с ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌ эффСктом Ρƒ всСх (наступлСниС рСмиссии, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ сниТСния Π΄ΠΎΠ· ΠΏΡ€ΠΈΠ½ΠΈΠΌΠ°Π΅ΠΌΡ‹Ρ… ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ²). Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ΠžΠΏΡ‹Ρ‚ провСдСния трансплантации Ρ„Π΅ΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… масс ΠΏΡ€ΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… патологичСских состояниях ΠΏΠΈΡ‰Π΅Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ‚Ρ€Π°ΠΊΡ‚Π° ΠΏΠΎΠΊΠ°Π·Π°Π» Π΅Π΅ ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, ΠΎΠ³Ρ€ΠΎΠΌΠ½Ρ‹ΠΉ тСрапСвтичСский ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ Ρ‚Π°ΠΊΠΈΡ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΊΠ°ΠΊ язвСнный ΠΊΠΎΠ»ΠΈΡ‚, болСзнь ΠšΡ€ΠΎΠ½Π°, C. difficile-ассоциированный ΠΊΠΎΠ»ΠΈΡ‚, Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ заболСвания Π–ΠšΠ’, мСтаболичСскиС Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡ. Π­Ρ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ эндоскопичСского ΠΏΠ΅Ρ€ΠΎΡ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Ρ‚ΠΎΠ΄Π° провСдСния трансплантации оказалась Π²Ρ‹ΡˆΠ΅ ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с Ρ‚Π°ΠΊΠΎΠ²ΠΎΠΉ Ρ€Π΅ΠΊΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ввСдСния ΠΈΠ»ΠΈ использования Π»ΠΈΠΎΡ„ΠΈΠ»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π° Π² капсулах

    Anthropogenic perturbation of the carbon fluxes from land to ocean

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    A substantial amount of the atmospheric carbon taken up on land through photosynthesis and chemical weathering is transported laterally along the aquatic continuum from upland terrestrial ecosystems to the ocean. So far, global carbon budget estimates have implicitly assumed that the transformation and lateral transport of carbon along this aquatic continuum has remained unchanged since pre-industrial times. A synthesis of published work reveals the magnitude of present-day lateral carbon fluxes from land to ocean, and the extent to which human activities have altered these fluxes. We show that anthropogenic perturbation may have increased the flux of carbon to inland waters by as much as 1.0 Pg C yrβˆ’1 since pre-industrial times, mainly owing to enhanced carbon export from soils. Most of this additional carbon input to upstream rivers is either emitted back to the atmosphere as carbon dioxide (~0.4 Pg C yrβˆ’1) or sequestered in sediments (~0.5 Pg C yrβˆ’1) along the continuum of freshwater bodies, estuaries and coastal waters, leaving only a perturbation carbon input of ~0.1 Pg C yrβˆ’1 to the open ocean. According to our analysis, terrestrial ecosystems store ~0.9 Pg C yrβˆ’1 at present, which is in agreement with results from forest inventories but significantly differs from the figure of 1.5 Pg C yrβˆ’1 previously estimated when ignoring changes in lateral carbon fluxes. We suggest that carbon fluxes along the land–ocean aquatic continuum need to be included in global carbon dioxide budgets
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