14 research outputs found
Polysaccharides Based Nanoparticles as Protein Oral Delivery System
Ovalbumin loaded chitosan and pectin based composite nanoparticles were obtained. The mean size,
morphology and zeta potential of the nanoparticles were determined by dynamic light scattering (DLS) and
atomic force microscopy (AFM). Effect oral administration of obtained nanoparticles on the immune response
was studied.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3548
The history of the development of national traumatology on the example of medical and scientific activities of Saratov Research Institute of Traumatology and Orthopedics (SarNIITO) (1950-1980)
We outlined and described basic directions of national traumatology development at the period of 1950-1980 illustrated by the example of Saratov traumatological school, estimated the contribution of SarNIITO traumatologists into this development at the abovementioned period, depicted syna β one of the founders of acute trauma clinics.</p
Πnaphylactic shock. Π‘linical guidelines
Anaphylactic shock is a severe life-threatening condition caused by medicines, food, hymenoptera, animal poisons, etc. Therefore, anaphylactic shock (anaphylaxis) can develop both in medical institution and outside it, and physicians of any specialties should be ready to treat this condition. In this regard, clinical guidelines for anaphylactic shock have been developed. These recommendations were approved by the Russian Association of Allergy and Clinical Immunology (Protocol No. 743/12 dated December 30, 2020) and the Federation of Anesthesiologists and Resuscitators (Protocol No. 1 dated January 13, 2021), approved at a meeting of the Scientific and Practical Council of the Ministry of Health of the Russian Federation (Protocol No. 743/12 dated December 10, 2020). Guidelines covered a number of nosologies corresponding to codes of the International Statistical Classification of Diseases and Related Health Problems: T 78.0; T 78.2; T 80.5; T 88.6. The clinical guidelines systematize modern data on etiology, epidemiology, classification, clinical picture, diagnosis, treatment, and prevention of anaphylactic shock. In addition, an algorithm for managing a patient with anaphylactic shock has been developed. Clinical guidelines for anaphylactic shock are intended for practitioners of all specialties, students, and teachers of medical universities, residents, and graduate students
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΏΠΈΡΠ΅Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° (ΠΏΠ΅ΡΠ²ΡΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠΏΡΡ)
Materials and Methods: Following primary identification and typing of gut flora composition using microbiological, genetic and metabolomic methods, microbiota substrate pre-sampled from prepared healthy donors was administered to 30 patients with various GIT conditions (pseudomembranous Clostridium colitis, Colitis ulcerosa, Grohn's disease, irritable bowel syndrome, chronic fatigue syndrome). The efficiency of the procedure was determined on the basis of the clinical presentation, lab test results and comparison of microbiota condition prior to transplantation and at least at three points after transplantation - in 2 weeks, 1 and 3 months, using microbiological and metagenomic methods. Study Results: Following one procedure, all patients with antibiotic-associated Clostridium difficile colitis had remission and their normal microflora recovered. Patients with inflammatory GIT conditions had 1 to 2 procedures (depending on the process severity) in addition to their basic therapy, and the positive effect was recorded in all patients (remission, possible drug dose reduction). Conclusion: Faecal transplantation in various pathological GIT conditions demonstrated its perspective and huge therapeutic potential for Colitis ulcerosa, Grohn's disease, C. difficile-associated colitis, functional GIT conditions, metabolic disorders. The efficiency of endoscopic oral transplantation was higher as compared to rectal administration or lyophilized material in capsules.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΏΠΎΠΊΠ°Π·Π°ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° (ΠΠΠ’). ΠΠΈΠ·Π°ΠΉΠ½: ΠΎΡΠΊΡΡΡΠΎΠ΅ Π½Π΅ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠ°Π²Π° ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
, Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΎΠΌΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΡΠ±ΡΡΡΠ°Ρ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ, ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π·Π°Π±ΡΠ°Π½Π½ΠΎΠΉ Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΡΡ
Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ½ΠΎΡΠΎΠ², Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ 30 Π±ΠΎΠ»ΡΠ½ΡΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ ΠΠΠ’ (ΠΏΡΠ΅Π²Π΄ΠΎΠΌΠ΅ΠΌΠ±ΡΠ°Π½ΠΎΠ·Π½ΡΠΌ ΠΊΠ»ΠΎΡΡΡΠΈΠ΄ΠΈΠΉΠ½ΡΠΌ ΠΊΠΎΠ»ΠΈΡΠΎΠΌ, ΡΠ·Π²Π΅Π½Π½ΡΠΌ ΠΊΠΎΠ»ΠΈΡΠΎΠΌ, Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΠΡΠΎΠ½Π°, ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠ°Π·Π΄ΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°, ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ°Π»ΠΎΡΡΠΈ). ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΏΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, ΠΎΠ±ΡΠ΅ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΈ ΠΏΡΡΠ΅ΠΌ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π΄ΠΎ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠΈ ΠΈ Π² ΠΌΠΈΠ½ΠΈΠΌΡΠΌ ΡΡΠ΅Ρ
ΡΠ΅ΠΏΠ΅ΡΠ½ΡΡ
ΡΠΎΡΠΊΠ°Ρ
- ΡΠ΅ΡΠ΅Π· 2 Π½Π΅Π΄Π΅Π»ΠΈ, 1 ΠΈ 3 ΠΌΠ΅ΡΡΡΠ° ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ, Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠ΅ΡΠ°Π³Π΅Π½ΠΎΠΌΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ². Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎ-Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Clostridium difficile-ΠΊΠΎΠ»ΠΈΡΠΎΠΌ ΠΏΠΎΡΠ»Π΅ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ Π½Π°ΡΡΡΠΏΠ°Π»ΠΈ ΡΠ΅ΠΌΠΈΡΡΠΈΡ ΠΈ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ. ΠΠΎΠ»ΡΠ½ΡΠΌ Ρ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Π½Π° ΡΠΎΠ½Π΅ Π±Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΎΡ 1 Π΄ΠΎ 2 ΠΏΡΠΎΡΠ΅Π΄ΡΡ (Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°) Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΡΡΡΠ΅ΠΊΡΠΎΠΌ Ρ Π²ΡΠ΅Ρ
(Π½Π°ΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΌΠΈΡΡΠΈΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π΄ΠΎΠ· ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π΅ΠΌΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ²). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΏΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΡΠ΅ΠΊΠ°Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΡ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΡΡ
ΠΏΠΈΡΠ΅Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° ΠΏΠΎΠΊΠ°Π·Π°Π» Π΅Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΠΎΠ³ΡΠΎΠΌΠ½ΡΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΠ°ΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΊΠ°ΠΊ ΡΠ·Π²Π΅Π½Π½ΡΠΉ ΠΊΠΎΠ»ΠΈΡ, Π±ΠΎΠ»Π΅Π·Π½Ρ ΠΡΠΎΠ½Π°, C. difficile-Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΊΠΎΠ»ΠΈΡ, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΠΠ’, ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ Π²ΡΡΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΊΠΎΠ²ΠΎΠΉ ΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π»ΠΈΠΎΡΠΈΠ»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π² ΠΊΠ°ΠΏΡΡΠ»Π°Ρ
Segregation of the Eu impurity as function of its concentration in the melt for growing of the lead telluride doped crystals by the Bridgman method
Enzymatic determination of some pharmaceuticals in direct and reversed sodium dodecyl sulfate micelles
Anthropogenic perturbation of the carbon fluxes from land to ocean
A substantial amount of the atmospheric carbon taken up on land through photosynthesis and chemical weathering is transported laterally along the aquatic continuum from upland terrestrial ecosystems to the ocean. So far, global carbon budget estimates have implicitly assumed that the transformation and lateral transport of carbon along this aquatic continuum has remained unchanged since pre-industrial times. A synthesis of published work reveals the magnitude of present-day lateral carbon fluxes from land to ocean, and the extent to which human activities have altered these fluxes. We show that anthropogenic perturbation may have increased the flux of carbon to inland waters by as much as 1.0 Pg C yrβ1 since pre-industrial times, mainly owing to enhanced carbon export from soils. Most of this additional carbon input to upstream rivers is either emitted back to the atmosphere as carbon dioxide (~0.4 Pg C yrβ1) or sequestered in sediments (~0.5 Pg C yrβ1) along the continuum of freshwater bodies, estuaries and coastal waters, leaving only a perturbation carbon input of ~0.1 Pg C yrβ1 to the open ocean. According to our analysis, terrestrial ecosystems store ~0.9 Pg C yrβ1 at present, which is in agreement with results from forest inventories but significantly differs from the figure of 1.5 Pg C yrβ1 previously estimated when ignoring changes in lateral carbon fluxes. We suggest that carbon fluxes along the landβocean aquatic continuum need to be included in global carbon dioxide budgets