761 research outputs found
Effectiveness and safety of betrixaban extended prophylaxis for venous thromboembolism compared with standard-duration prophylaxis intervention in acute medically ill patients : a systematic literature review and network meta-analysis
Aims: To determine the clinical effectiveness and safety of venous thromboembolism (VTE) prophylaxis using US- and Europe-approved anticoagulants relative to extended-duration VTE prophylaxis with betrixaban. Low molecular weight heparins (LMWHs), unfractionated heparin (UFH), fondaparinux sodium and placebo were each compared to betrixaban, as standard-duration VTE prophylaxis for hospitalized, non-surgical patients with acute medical illness at risk of VTE.
Materials and methods: A systematic literature review was conducted up to June 2019 to identify randomized controlled trials (RCTs) of VTE prophylaxis in hospitalized, non-surgical patients with acute medical illness at risk of VTE. Studies that reported the occurrence of VTE events (including death) and, where possible, major bleeding, from treatment initiation to 20–50 days thereafter were retrieved and extracted. A Bayesian fixed effect network meta-analysis was used to estimate efficacy and safety of betrixaban compared with standard-duration VTE prophylaxis.
Results: Seven RCTs were analyzed which compared betrixaban, LMWHs, UFH, fondaparinux sodium, or placebo. There were significantly higher odds (median odds [95% credible interval]) of VTE with LMWHs (1.38 [1.12–1.70]), UFH (1.60 [1.05–2.46]), and placebo (2.37 [1.55–3.66]) compared with betrixaban. There were significantly higher odds of VTE-related death with placebo (7.76 [2.14–34.40]) compared with betrixaban. No significant differences were observed for the odds of major bleeding with all comparators, VTE-related death with any active standard-duration VTE prophylaxis, or of VTE with fondaparinux sodium, compared with betrixaban.
Limitations and conclusions: In this indirect comparison, betrixaban was shown to be an effective regimen with relative benefits compared with LMWHs and UFH. This indicates that betrixaban could reduce the burden of VTE in at-risk hospitalized patients with acute medical illness who need extended prophylaxis, though without direct comparative evidence, stronger conclusions cannot be drawn
Universality of Frequency and Field Scaling of the Conductivity Measured by Ac-Susceptibility of a Ybco-Film
Utilizing a novel and exact inversion scheme, we determine the complex linear
conductivity from the linear magnetic ac-susceptibility
which has been measured from 3\,mHz to 50\,MHz in fields between 0.4\,T and
4\,T applied parallel to the c-axis of a 250\,nm thin disk. The frequency
derivative of the phase and the dynamical scaling of
above and below provide clear evidence for a
continuous phase transition at to a generic superconducting state. Based
on the vortex-glass scaling model, the resulting critical exponents and
are close to those frequently obtained on films by other means and
associated with an 'isotropic' vortex glass. The field effect on
can be related to the increase of the glass coherence length,
.Comment: 8 pages (5 figures upon request), revtex 3.0, APK.94.01.0
Properties of the random field Ising model in a transverse magnetic field
We consider the effect of a random longitudinal field on the Ising model in a
transverse magnetic field. For spatial dimension , there is at low
strength of randomness and transverse field, a phase with true long range order
which is destroyed at higher values of the randomness or transverse field. The
properties of the quantum phase transition at zero temperature are controlled
by a fixed point with no quantum fluctuations. This fixed point also controls
the classical finite temperature phase transition in this model. Many critical
properties of the quantum transition are therefore identical to those of the
classical transition. In particular, we argue that the dynamical scaling is
activated, i.e, the logarithm of the diverging time scale rises as a power of
the diverging length scale
Ground state non-universality in the random field Ising model
Two attractive and often used ideas, namely universality and the concept of a
zero temperature fixed point, are violated in the infinite-range random-field
Ising model. In the ground state we show that the exponents can depend
continuously on the disorder and so are non-universal. However, we also show
that at finite temperature the thermal order parameter exponent one half is
restored so that temperature is a relevant variable. The broader implications
of these results are discussed.Comment: 4 pages 2 figures, corrected prefactors caused by a missing factor of
two in Eq. 2., added a paragraph in conclusions for clarit
Fijian sea krait behavior relates to fine - scale environmental heterogeneity in old - growth coastal forest: the importance of integrated land – sea management for protecting amphibious animals
The importance of terrestrial coastal ecosystems for maintaining healthy coral reef ecosystems remains understudied. Sea kraits are amphibious snakes that require healthy coral reefs for foraging, but little is known about their requirements of terrestrial habitats, where they slough their skin, digest prey, and breed. Using concurrent microclimate measurements and behavior surveys, we show that a small, topographically flat atoll in Fiji with coastal forest provides many microhabitats that relate to the behaviors of Yellow Lipped Sea Kraits, Laticauda colubrina. Microclimates were significantly related to canopy cover, leaf litter depth, and distance from the high-water mark (HWM). Sea kraits were almost exclusively observed in coastal forest within 30 m of the HWM. Sloughing of skins only occurred within crevices of mature or dying trees. Resting L. colubrina were significantly more likely to occur at locations with higher mean diurnal temperatures, lower leaf litter depths, and shorter distances from the HWM. On Leleuvia, behavior of L. colubrina therefore relates to environmental heterogeneity created by old-growth coastal forests, particularly canopy cover and crevices in mature and dead tree trunks. The importance of healthy coastal habitats, both terrestrial and marine, for L. colubrina suggests it could be a good flagship species for advocating integrated land-sea management. Furthermore, our study highlights the importance of coastal forests and topographically flat atolls for biodiversity conservation. Effective conservation management of amphibious species that utilize land- and seascapes is therefore likely to require a holistic approach that incorporates connectivity among ecosystems and environmental heterogeneity at all relevant scales
Dynamic scaling and aging phenomena in short-range Ising spin glass: CuCoCl-FeCl graphite bi-intercalation compound
Static and dynamic behavior of short-range Ising-spin glass
CuCoCl-FeCl graphite bi-intercalation compounds
(GBIC) has been studied with SQUID DC and AC magnetic susceptibility. The
dependence of the zero-field relaxation time above a spin-freezing
temperature (= 3.92 0.11 K) is well described by critical slowing
down. The absorption below decreases with
increasing angular frequency , which is in contrast to the case of 3D
Ising spin glass. The dynamic freezing temperature at which
dd, is determined as a function of
frequency (0.01 Hz 1 kHz) and magnetic field (0 5 kOe). The dynamic scaling analysis of the relaxation time
defined as at suggests the absence of
SG phase in the presence of (at least above 100 Oe). Dynamic scaling
analysis of and near
leads to the critical exponents ( = 0.36 0.03, = 3.5
0.4, = 1.4 0.2, = 6.6 1.2, = 0.24
0.02, and = 0.13 0.02). The aging phenomenon is studied through
the absorption below . It obeys a
power-law decay with an exponent . The rejuvenation effect is also observed under
sufficiently large (temperature and magnetic-field) perturbations.Comment: 14 pages, 19 figures; to be published in Phys. Rev. B (September 1,
2003
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