336 research outputs found
Treadmill exercise activates subcortical neural networks and improves walking after a stroke
BACKGROUND AND PURPOSE: Stroke often impairs gait thereby reducing mobility and fitness and promoting chronic disability. Gait is a complex sensorimotor function controlled by integrated cortical, subcortical, and spinal networks. The mechanisms of gait recovery after stroke are not well understood. This study examines the hypothesis that progressive task-repetitive treadmill exercise (T-EX) improves fitness and gait function in subjects with chronic hemiparetic stroke by inducing adaptations in the brain (plasticity).METHODS: A randomized controlled trial determined the effects of 6-month T-EX (n=37) versus comparable duration stretching (CON, n=34) on walking, aerobic fitness and in a subset (n=15/17) on brain activation measured by functional MRI.RESULTS: T-EX significantly improved treadmill-walking velocity by 51% and cardiovascular fitness by 18% (11% and -3% for CON, respectively; P<0.05). T-EX but not CON affected brain activation during paretic, but not during nonparetic limb movement, showing 72% increased activation in posterior cerebellar lobe and 18% in midbrain (P<0.005). Exercise-mediated improvements in walking velocity correlated with increased activation in cerebellum and midbrain.CONCLUSIONS: T-EX improves walking, fitness and recruits cerebellum-midbrain circuits, likely reflecting neural network plasticity. This neural recruitment is associated with better walking. These findings demonstrate the effectiveness of T-EX rehabilitation in promoting gait recovery of stroke survivors with long-term mobility impairment and provide evidence of neuroplastic mechanisms that could lead to further refinements in these paradigms to improve functional outcomes
Curved Tails in Polymerization-Based Bacterial Motility
The curved actin ``comet-tail'' of the bacterium Listeria monocytogenes is a
visually striking signature of actin polymerization-based motility. Similar
actin tails are associated with Shigella flexneri, spotted-fever Rickettsiae,
the Vaccinia virus, and vesicles and microspheres in related in vitro systems.
We show that the torque required to produce the curvature in the tail can arise
from randomly placed actin filaments pushing the bacterium or particle. We find
that the curvature magnitude determines the number of actively pushing
filaments, independent of viscosity and of the molecular details of force
generation. The variation of the curvature with time can be used to infer the
dynamics of actin filaments at the bacterial surface.Comment: 8 pages, 2 figures, Latex2
A Quantum-Mechanical Equivalent-Photon Spectrum for Heavy-Ion Physics
In a previous paper, we calculated the fully quantum-mechanical cross section
for electromagnetic excitation during peripheral heavy-ion collisions. Here, we
examine the sensitivity of that cross section to the detailed structure of the
projectile and target nuclei. At the transition energies relevant to nuclear
physics, we find the cross section to be weakly dependent on the projectile
charge radius, and to be sensitive to only the leading momentum-transfer
dependence of the target transition form factors. We exploit these facts to
derive a quantum-mechanical ``equivalent-photon spectrum'' valid in the
long-wavelength limit. This improved spectrum includes the effects of
projectile size, the finite longitudinal momentum transfer required by
kinematics, and the response of the target nucleus to the off-shell photon.Comment: 19 pages, 5 figure
Constraining the dark energy dynamics with the cosmic microwave background bispectrum
We consider the influence of the dark energy dynamics at the onset of cosmic
acceleration on the Cosmic Microwave Background (CMB) bispectrum, through the
weak lensing effect induced by structure formation. We study the line of sight
behavior of the contribution to the bispectrum signal at a given angular
multipole : we show that it is non-zero in a narrow interval centered at a
redshift satisfying the relation , where the
wavenumber corresponds to the scale entering the non-linear phase, and is
the cosmological comoving distance. The relevant redshift interval is in the
range 0.1\lsim z\lsim 2 for multipoles 1000\gsim\ell\gsim 100; the signal
amplitude, reflecting the perturbation dynamics, is a function of the
cosmological expansion rate at those epochs, probing the dark energy equation
of state redshift dependence independently on its present value. We provide a
worked example by considering tracking inverse power law and SUGRA Quintessence
scenarios, having sensibly different redshift dynamics and respecting all the
present observational constraints. For scenarios having the same present
equation of state, we find that the effect described above induces a projection
feature which makes the bispectra shifted by several tens of multipoles, about
10 times more than the corresponding effect on the ordinary CMB angular power
spectrum.Comment: 15 pages, 7 figures, matching version accepted by Physical Review D,
one figure improve
Dark Synergy: Gravitational Lensing and the CMB
Power spectra and cross-correlation measurements from the weak gravitational
lensing of the cosmic microwave background (CMB) and the cosmic shearing of
faint galaxies images will help shed light on quantities hidden from the CMB
temperature anisotropies: the dark energy, the end of the dark ages, and the
inflationary gravitational wave amplitude. Even with modest surveys, both types
of lensing power spectra break CMB degeneracies and they can ultimately improve
constraints on the dark energy equation of state w by over an order of
magnitude. In its cross correlation with the integrated Sachs-Wolfe effect, CMB
lensing offers a unique opportunity for a more direct detection of the dark
energy and enables study of its clustering properties. By obtaining source
redshifts and cross-correlations with CMB lensing, cosmic shear surveys provide
tomographic handles on the evolution of clustering correspondingly better
precision on the dark energy equation of state and density. Both can indirectly
provide detections of the reionization optical depth and modest improvements in
gravitational wave constraints which we compare to more direct constraints.
Conversely, polarization B-mode contamination from CMB lensing, like any other
residual foreground, darkens the prospects for ultra-high precision on
gravitational waves through CMB polarization requiring large areas of sky for
statistical subtraction. To evaluate these effects we provide fitting formula
for the evolution and transfer function of the Newtonian gravitational
potential.Comment: 16 pages, 11 figures submitted to PR
An Electrode Array for Limiting Blood Loss During Liver Resection: Optimization via Mathematical Modeling
Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5 × 0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97 ºC throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels
Tensile strength, friability and organic carbon in an oxisol under a crop-livestock system
Geochemical paleoredox indicators in organic-rich shales of the Irati Formation, Permian of the Paraná Basin, southern Brazil
Effect of age, sex and gender on pain sensitivity: A narrative review
© 2017 Eltumi And Tashani. Introduction: An increasing body of literature on sex and gender differences in pain sensitivity has been accumulated in recent years. There is also evidence from epidemiological research that painful conditions are more prevalent in older people. The aim of this narrative review is to critically appraise the relevant literature investigating the presence of age and sex differences in clinical and experimental pain conditions. Methods: A scoping search of the literature identifying relevant peer reviewed articles was conducted on May 2016. Information and evidence from the key articles were narratively described and data was quantitatively synthesised to identify gaps of knowledge in the research literature concerning age and sex differences in pain responses. Results: This critical appraisal of the literature suggests that the results of the experimental and clinical studies regarding age and sex differences in pain contain some contradictions as far as age differences in pain are concerned. While data from the clinical studies are more consistent and seem to point towards the fact that chronic pain prevalence increases in the elderly findings from the experimental studies on the other hand were inconsistent, with pain threshold increasing with age in some studies and decreasing with age in others. Conclusion: There is a need for further research using the latest advanced quantitative sensory testing protocols to measure the function of small nerve fibres that are involved in nociception and pain sensitivity across the human life span. Implications: Findings from these studies should feed into and inform evidence emerging from other types of studies (e.g. brain imaging technique and psychometrics) suggesting that pain in the older humans may have unique characteristics that affect how old patients respond to intervention
- …