Learning from the past: Analysis of disaster management structures, policies and institutions in Pakistan

Purpose: The paper provides a historical analysis of the disaster management structure, policies and institutions in Pakistan between 1947 and 2005, and highlights the contemporary challenges in view of the learning from the past. Design/methodology/approach: The paper uses a historic-integrative case study approach to disaster management and risk reduction policy, planning and practice. Qualitative data was collected through purposive sampling and a case study design was adopted. A broad range of actors was recruited as research participants. In total, 22 semi-structured in-depth interviews were conducted in relation to this study in six different districts of Pakistan to achieve insight into the role of different institutions and stakeholders. Findings: Overall, the post-colonial flood-centric policy framework and fragmented responsibilities of different disaster management institutions show the lack of an effective institutional structure for disaster management and mitigation in Pakistan, particularly at the local level. Until the event of the 2005 earthquake, policies heavily relied on attaining immediate and short-term goals of Response and Relief while ignoring the long-term objectives of strategic planning for Prevention and Preparedness as well as capacity building and empowerment of local institutions and communities. Practical implications: The analysis explains, in part, why disaster planning and management needs to be given due attention in the developing countries at different policy scales (from local to national) especially in the face of limited resources, and what measures should be taken to improve effectiveness at different phases of the disaster management cycle. Originality/value: The paper advances the importance of a historical case study approach to disaster management and mitigation. The empirical work provides original research evidence about the approaches to dealing with disasters in Pakistan and thus enriches existing knowledge of disaster management policy and planning about the country

I will not go, I cannot go: cultural and social limitations of disaster preparedness in Asia, Africa, and Oceania

While much work has been invested in addressing the economic and technical basis of disaster preparedness, less effort has been directed towards understanding the cultural and social obstacles to and opportunities for disaster risk reduction. This paper presents local insights from five different national settings into the cultural and social contexts of disaster preparedness. In most cases, an early warning system was in place, but it failed to alert people to diverse environmental shocks. The research findings show that despite geographical and typological differences in these locations, the limitations of the systems were fairly similar. In Kenya, people received warnings, but from contradictory systems, whereas in the Philippines and on the island of Saipan, people did not understand the messages or take them seriously. In Bangladesh and Nepal, however, a deeper cultural and religious reasoning serves to explain disasters, and how to prevent them or find safety when they strike

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

‘Business-in-a-Box’ as transformative social innovation

Business-in-a-Box (BiB) is part of a community-based development programme in rural Pakistan which has led to some transformative and capacity building actions. Initiated by the non-governmental Rural Support Programme Network, the model closely aligns with the approach relating social innovation for human and community development to three key aspects: satisfaction of basic human needs; improving social relations; and, socio-political empowerment

‘Business-in-a-Box’ as transformative social innovation

Business-in-a-Box (BiB) is part of a community-based development programme in rural Pakistan which has led to some transformative and capacity building actions. Initiated by the non-governmental Rural Support Programme Network, the model closely aligns with the approach relating social innovation for human and community development to three key aspects: satisfaction of basic human needs; improving social relations; and, socio-political empowerment