A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry

Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry–specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We found the risk allele to be significantly associated with earlier age at diagnosis, more aggressive disease, and enriched in men with a PCa family history (32% of high-risk familial cases carried the variant vs 23% of cases without a family history and 12% of controls). For cases with two or more first-degree relatives with PCa who had at least one family member diagnosed at age <60 yr, the odds ratios for TA heterozygotes and TT homozygotes were 3.92 (95% confidence interval [CI] = 2.13–7.22) and 33.41 (95% CI = 10.86–102.84), respectively. Among men with a PCa family history, the absolute risk by age 60 yr reached 21% (95% CI = 17–25%) for TA heterozygotes and 38% (95% CI = 13–65%) for TT homozygotes. We estimate that in men of African ancestry, rs72725854 accounts for 32% of the total familial risk explained by all known PCa risk variants. Patient summary: We found that rs72725854, an African ancestry–specific risk variant, is more common in men with a family history of prostate cancer and in those diagnosed with prostate cancer at younger ages. Men of African ancestry may benefit from the knowledge of their carrier status for this genetic risk variant to guide decisions about prostate cancer screening. © 2020 The AuthorsThe African ancestry–specific prostate cancer risk variant at 8q24, rs72725854, is enriched in men diagnosed at younger ages and men with a prostate cancer family history. Carriers of this risk allele would benefit from regular and earlier prostate cancer screening

One century of forest rehabilitation in the Philippines: approaches, outcomes and lessons

Forest cover is decreasing or very low in many tropical landscapes following decades of logging, fire and other human disturbances. At the same time, there are large and growing areas of degraded forest lands that need to be rehabilitated to again provide forest goods and services and meet local livelihood needs. National, international, local and private agencies have invested in innumerable rehabilitation initiatives in the tropics. Lots of money has been spent, but have these efforts actually increased forest cover, helped impoverished upland communities, enhanced biodiversity and environmental services, or contributed to meeting timber needs? Did they address the underlying degradation causes and were the rehabilitated areas maintained in the long term? What are the most promising approaches? Which ones can be replicated at low cost by local institutions and actors? Which ones are self-sustaining at the local level? What enabling factors are required to sustain the efforts?. This report reviewing forest rehabilitation in the Philippines is part of a larger study by the Center for International Forestry Research (CIFOR) and national partners to assess efforts across six countries to try and answer the above questions and derive lessons for planning and guiding future efforts. The countries are Peru, Brazil, Indonesia, Vietnam, China and the Philippines. The study aimed to increase the chances of success for future rehabilitation efforts by identifying the approaches that contributed to longer-term sustainability and positive outcomes for different stakeholders