Exchange Effects in the Invar Hardening: Fe0.65Ni0.35Fe_{0.65}Ni_{0.35} as a test case

An increase of the critical resolved shear stress of Invar alloys (Invar hardening) with a lowering temperature is explained. The effect is caused by a growth of the exchange interaction between dangling $d$-electron states of dislocation cores and paramagnetic obstacles (e.g., Ni atoms in FeNi alloys) which occurs below the Curie temperature. The spins of the two electrons align along the magnetization due to the exchange interaction with the surrounding atoms of the ferromagnetic. The exchange interaction between the dislocations and obstacles is enhanced in Invars due to a strong growth of the magnetic moments of atoms under the action of elastic strains near the dislocation cores. Parameters characterizing the exchange interaction are determined for the case of the Fe$_{0.65}$Ni$_{0.35}$ Invar. The influence of the internal magnetic field on the dislocation detachment from the obstacles is taken into account. The obtained temperature dependence of the critical resolved shear stress in the Fe$_{0.65}$Ni$_{0.35}$ Invar agrees well with the available experimental data. Experiments facilitating a further check of the theoretical model are suggested.Comment: 8 pages, 2 figure

Modeling the actinides with disordered local moments

A first-principles disordered local moment (DLM) picture within the local-spin-density and coherent potential approximations (LSDA+CPA) of the actinides is presented. The parameter free theory gives an accurate description of bond lengths and bulk modulus. The case of $\delta$-Pu is studied in particular and the calculated density of states is compared to data from photo-electron spectroscopy. The relation between the DLM description, the dynamical mean field approach and spin-polarized magnetically ordered modeling is discussed.Comment: 6 pages, 4 figure

A profile of antidepressive effects of agomelatine and a current view on the mechanism of its action

Agomelatine is one of the latest antidepressants (melatoninergic agonists) with a new mechanism of action. From the positions of classical monoaminoergic theory, tts mechanism of action is difficult to understand, because the drug increases the levels of monoamines and neurotrophic factors, while not affecting their reuptake and negative feedback, which control neurotransmission level. Besides the effect on suprachiasmatic nucleus, a relevant role in the mechanism of action of agomelatine plays its special functionally selective (with regard to intracellular signaling pathways) interaction with heteromeric complexes of serotonin 5-НТ2С and melatonin MT2 receptors in the hippocampus and cerebral cortex. Agomelatine is competitive to other modern antidepressants in the efficacy assessed by the percentage of complete responders and superior in the total frequency of remissions. Compared to other SSRI antidepressants, agomelatine is more effective for anhedonia. In these cases, agomelatine increases the level of brain-derived neurotrophic factor (BDNF) in the blood of responders. © 2017, Media Sphera Publishing Group. All rights reserved

A profile of antidepressive effects of agomelatine and a current view on the mechanism of its action

Agomelatine is one of the latest antidepressants (melatoninergic agonists) with a new mechanism of action. From the positions of classical monoaminoergic theory, tts mechanism of action is difficult to understand, because the drug increases the levels of monoamines and neurotrophic factors, while not affecting their reuptake and negative feedback, which control neurotransmission level. Besides the effect on suprachiasmatic nucleus, a relevant role in the mechanism of action of agomelatine plays its special functionally selective (with regard to intracellular signaling pathways) interaction with heteromeric complexes of serotonin 5-НТ2С and melatonin MT2 receptors in the hippocampus and cerebral cortex. Agomelatine is competitive to other modern antidepressants in the efficacy assessed by the percentage of complete responders and superior in the total frequency of remissions. Compared to other SSRI antidepressants, agomelatine is more effective for anhedonia. In these cases, agomelatine increases the level of brain-derived neurotrophic factor (BDNF) in the blood of responders. © 2017, Media Sphera Publishing Group. All rights reserved