Peer reviewed abstract submitted to the College of Health Sciences, Osun State University Annual Scientific Conference, June 15-19, 2020

Introduction: MDR-TB poses a significant challenge to global management of TB. Laboratories in many countries among which include Nigeria are unable to evaluate drug resistance, and clinical predictors of MDR-TB might help target suspected patients.Method: The study was a cross sectional study design. Multistage sampling technique was employed in the selection of 403 tuberculosis patients. Data were analyzed using SPSS version 25. Level of significance was set at P<0.05.Results: Fifty three 53 (13.2%) of the total respondent had MDR-TB compare to national prevalence of 8% which is steeper among males 36(67.9%) (p>0.05). Education and Occupation shows a significant association with MDR-TB, (÷2=24.640, p = 0.007) and (÷2=14.416, p=0.006) respectively, smoking (r=0.074, p<0.05) and alcohol consumption (r=0.083, p>0.05) show no significant association with occurrence MDR-TB.Conclusion: Previous TB treatment and Adherence with treatment regimen were found to be the major risk factor for MDR-TB. Targeted educational intervention for patients and their contacts may minimize the non-adherence with prescribed TB treatment and lessen MDR-TB magnitude. Key words: TB Patients, MDR-TB, tuberculosis, risk factors

Modulation of Antioxidant Enzymes and Inflammatory Cytokines: Possible Mechanism of Anti-diabetic Effect of Ginger Extracts

Zingiber officinale is used in African traditional medicine to treat diabetes mellitus. Oxidative stress and inflammation are associated with the pathogenesis of diabetes mellitus and its complications. This investigation tested the hypothesis that extracts of Zingiber officinale inhibit oxidative stress and inflammation by enhancing antioxidant enzymes and TNF-α activity in STZ-induced diabetic rats. Wistar rats were randomly divided into groups (n=6) receiving different oral treatments consisting of vehicle, aqueous ginger extract (250 and 500 mg/kg), ethanol ginger extract (250 and 500 mg). The effect of Z. officinale was assessed in the STZ-induced diabetic rats after 6-week treatment on blood glucose; oxidative stress (using MDA level, SOD, CAT and GSH activities); and inflammation (using TNF-α). Both extracts of Z. officinale increased the intracellular activities of SOD, CAT and GSH. The extracts however caused a significant decrease in the MDA and inflammatory TNF-α level. These data indicate that mechanism of antidiabetic effects of ginger may be in part, due to inhibition of oxidative stress and inflammatory activity

A Short Review of the Concept and Principles of Supply Chain Management in Building Construction Industry

Supply chain management concept has found its way into the construction sector of the economy as a result of the inherent opportunity to improve performance. The concept has continued to attract increasing support among major stakeholders in the execution of construction projects. However, it was observed that the strategy is still at low level of adoption among professionals in the industry. Moreover, the low level of knowledge of the strategy and the inability to effectively put the principles of supply chain management to practice hinders the application. This study therefore advances the knowledge of supply chain management by undertaking an examination of few key areas on the concept with a view to improving the awareness and understanding among professionals and assist in designing a supply chain management strategy suitable for building development process. Relevant studies were identified for review by literature search using key words and concepts related to the topic of the current study. Thematic areas of discussion include the construction industry outlook, building development process, the principles and essentials of construction supply chain management. The understanding of basic principles and essentials of supply chain management is important to adopting, adapting, designing and deployment of the strategy in the construction industry and this constituted the purpose and focus of the study

Risk Factors Associated with MDR-TB among Tuberculosis Patients in Ibadan, Oyo state, Nigeria

Introduction: In Nigeria, patients accessing Directory Observed Therapy (DOTS) treatment are exposed to resistance to anti-TB drugs, hence is  considered a priority, only few studies have focused on the relevant risk factors, Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programsMethod: The study was a cross sectional study design. Multistage sampling technique was employed in the selection of 403 tuberculosis patients in Ibadan North Local Government Area of Oyo State. Data were collected using self-administered structured questionnaire, and analyzed using SPSS version 25. Level of significance was set at P<0.05.Results: Fifty three (13.2%) of the total respondent had Multidrug Resistant TB (MDR-TB) which is more among the males 36(67.9%) (p>0.05). Education and Occupation shows a significant association with MDR-TB, (χ2=24.640, p =0.007) and (χ2=14.416, p = 0.006) respectively,risk factors such asprevious TB treatment and Adherence with treatment regimen (r=0.270, p<0.05), HIV (r=0.168, p<0.05) and smoking (ß=0.107, t=2.144, p<0.05) were statistically associated with development of acquired MDR-TB.Conclusion: This finding revealed that Previous TB treatment andAdherence with treatment regimen were found to be the major risk factor for MDR-TB. Targeted educational intervention for patients and their contacts may minimize the nonadherence with prescribed TB treatment and lessen MDR-TB magnitude. High quality directly observed treatment should be strengthened to ensure that the previously treated patients can receive standard and regular regimens. Keywords: TB Patients, MDR-TB, tuberculosis, Risk factors.   French Title: Facteurs de risque associés à la MDR-TB parmi les patientstuberculeux à Ibadan, état d'Oyo, Nigéria Introduction: Au Nigéria, les patients accédant au traitement DOTS (Directory Observed Therapy) sont exposés à une résistance aux médicaments  antituberculeux, ce qui est considéré comme une priorité, seules quelques études se sont concentrées sur les facteurs de risque pertinents. Les facteurs menant au développement d'être compris pour développer des stratégies de contrôle appropriées pour les programmes nationaux.Méthode de l'étude: L'étude était un plan d'étude transversale. Une technique d'échantillonnage à plusieurs degrés a été utilisée pour  sélectionner 403 patients tuberculeux dans la région du gouvernement local d'Ibadan Nord de l'état d'Oyo. Les données ont été collectées à l'aide d'un questionnaire structuré auto-administré et analysées à l'aide de la version 25 du SPSS. Le niveau de signification a été fixé à P <0,05.Résultats de l'étude: Cinquante-trois (13,2%) des répondants totaux avaient une tuberculose multi résistante (MDR-TB), ce qui est plus parmi les hommes 36 (67,9%) (p> 0,05). L'éducation et la profession montrent une association significative avec la TB-MR, (χ2 = 24,640, p = 0,007) et (χ2 = 14,416, p = 0,006) respectivement, des facteurs de risque tels que le traitement antituberculeux antérieur et l'observance du schéma thérapeutique (r =0,270, p <0,05), le VIH (r = 0,168, p <0,05) et le tabagisme (ß = 0,107, t = 2,144, p <0,05) étaient statistiquement associés au développement de la TB-MR acquise.Conclusion: Ce résultat a révélé que le traitement antituberculeux antérieur et l'observance du schéma thérapeutique étaient les principaux  facteurs de risque de TB-MR. Une intervention éducative ciblée pour les patients et leurs contacts peut minimiser la non-observance du traitement antituberculeux prescrit et réduire l'ampleur de la TB-MR. Un traitement de haute qualité directement observé doit être renforcé pour garantir queles patients précédemment traités puissent recevoir des schémas standards et réguliers. Mots-clés: Patients TB, MDR-TB, tuberculose, facteurs de risque &nbsp

Computational study of Cattaneo–Christov heat flux on cylindrical surfaces using CNT hybrid nanofluids: A solar-powered ship implementation

This study examines the potential of using nanofluids in solar thermal energy systems. Nanofluids are known to exhibit high convection heat transfer coefficients, low specific heat, and density, making them ideal for improving the performance of solar thermal energy systems. However, this computational study investigates the application of Cattaneo-Christov heat flux on cylindrical surfaces using carbon nanotube (CNT) hybrid nanofluids, for use in a solar-powered ship. The work utilizes numerical simulations to analyze the heat transfer and fluid flow characteristics of the hybrid nanofluids. The research examines the use of single-walled and multi-walled carbon nanotubes (SWCNT and MWCNT) in engine oil (EO) as the working fluid. The Galerkin weighted residual method (GWRM) is utilized to solve the ordinary differential equations (ODEs) governing the system. The impact of various parameters, such as Cattaneo-Christov heat flux, solar thermal radiation, nonlinear stretching surface, slippery velocity, and porous media on the velocity equation, energy equation, and entropy generation are investigated and elaborated through detailed plots. The findings show that the MWCNT-SWCNT/EO hybrid nanofluid (HNF) exhibits maximum efficiency of around 2.4%, while the minimum efficiency is at 2.7%. This research provides valuable insights into the design and optimization of solar thermal systems for sustainable transportation