61 research outputs found
Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders
Functional significance of c-myb expression in normal and leukemic hematopoiesis.
No abstract available
Thrombopoietinâinduced CXC chemokines, NAPâ2 and PF4, suppress polyploidization and proplatelet formation during megakaryocyte maturation
CYCLIC IDIOPATHIC PURE ACQUIRED AMEGAKARYOCYTIC THROMBOCYTOPENIC PURPURA: A PATIENT TREATED WITH CYCLOSPORIN A
Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety
International audienc
Transitory hypomegakaryocytic thrombocytopenia: aetiological association with ethanol abuse and implications regarding regulation of human megakaryocytopoiesis
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