182 research outputs found
Termoreverzibilni mukoadhezivni in situ hidrogel za oftalmiÄku primjenu: dizajniranje i optimizacija koristeÄi kombinaciju polimera
The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 33ï36 ÂșC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.Cilj rada bio je razvoj i optimizacija termoreverzibilnog sustava za isporuku lijekova koji gelira in situ. Sustav je napravljen na bazi Pluronic F 127, a sadrĆŸi moksifloksacin hidroklorid kao modelni lijek. U radu je primjenjeno 32 potpuno faktorijsko dizajniranje s dva polimera, Pluronic F 68 i Gelrite kao nezavisnim varijablama koji su kombinirani s Pluronic F 127. Kao zavisne varijable odabrane su temperatura geliranja, ÄvrstoÄa gela, jaÄina bioadhezije, viskoznost i in vitro oslobaÄanje lijeka nakon 1 i 10 h. PronaÄeno je da Pluronic F 68 u kombinaciji s Pluronic F 127 ima znaÄajan uÄinak na temperaturu geliranja u rasponu od 33 do 36 ï°C. S druge strane, Gelrite ima povoljan uÄinak na jaÄinu bioadhezije, ÄvrstoÄu gela i oslobaÄanje lijeka. Razvijen je kvadratni matematiÄki model pomoÄu kojeg se moĆŸe predvidjeti temperatura geliranja, ÄvrstoÄa gela, jaÄina bioadhezije i oslobaÄanje ljekovite tvari
Superconductivity in CeO_{1-x}F_xFeAs with upper critical field of 94 T
We have successfully synthesized Ce based oxypnictide with fluorine doping
(CeO_{1-x}F_xFeAs) by a two step solid state reaction method. Detailed XRD and
EDX confirm the crystal structure and chemical compositions. We observe that an
extremely high Hc2(0) of 94 T can be achieved in the x = 0.1 composition. This
increase in Hc2(0) is accompanied by a decrease in transition temperature (38.4
K in x = 0.1 composition) from 42.5 K for the x = 0.2 phase. The in-plane
Ginzburg-Landau coherence length is estimated to be ~ 27 A at x = 0.2
suggesting a moderate anisotropy in this class of superconductors. The Seebeck
coefficient confirms the majority carrier to be electrons and strong dominance
of electron-electron correlations in this multiband superconductor
Severe diabetic papillopathy mimicking non-ar... [Med J Malaysia. 2012] - PubMed - NCBI
Mallika PS, Aziz S, Asok T, Chong MS, Tan AK, Chua CN
Thyroid Associated Ophthalmopathy: A Review
Thyroid associated ophthalmopathy is an autoimmune disorder affecting the orbital and periorbital tissues. Hyperthyroidism is commonly associated with thyroid associated ophthalmopathy, however in 5% to 10% of cases it is euthyroid. Genetic, environmental and endogenous factors play a role in the initiation of the thyroid ophthalmopathy. Smoking has been identified as the strongest risk factor for the development of the disorder. The pathogenesis involves activation of both humoral and cell mediated immunity with subsequent production of gycoaminoglycans, hyaluronic acid resulting in oedema formation, increase extraocular mass and adipogenesis in the orbit. The natural history of the disease progresses from active to inactive fibrotic stage over a period of years. Diagnosis is mainly clinical and almost all patients with ophthalmopathy exhibit some form of thyroid abnormality on further testing. Treatment is based on the clinical severity of the disease. Non-severe cases are managed by supportive measures to reduce the symptomatology and severe cases are treated by either medical or surgical decompression. Rehabilitative surgery is done for quiescent disease to reduce diplopia and improve cosmesis
Density-functional calculation of ionization energies of current-carrying atomic states
Current-density-functional theory is used to calculate ionization energies of
current-carrying atomic states. A perturbative approximation to full
current-density-functional theory is implemented for the first time, and found
to be numerically feasible. Different parametrizations for the
current-dependence of the density functional are critically compared. Orbital
currents in open-shell atoms turn out to produce a small shift in the
ionization energies. We find that modern density functionals have reached an
accuracy at which small current-related terms appearing in open-shell
configurations are not negligible anymore compared to the remaining difference
to experiment.Comment: 7 pages, 2 tables, accepted by Phys. Rev.
Charm multiplicity and the branching ratios of inclusive charmless b quark decays in the general two-Higgs-doublet models
In the framework of general two-Higgs-doublet models, we calculate the
branching ratios of various inclusive charmless b decays by using the low
energy effective Hamiltonian including next-to-leading order QCD corrections,
and examine the current status and the new physics effects on the determination
of the charm multiplicity and semileptonic branching ratio .
Within the considered parameter space, the enhancement to the ratio due to the charged-Higgs penguins can be as large as a factor of 8 (3) in
the model III (II), while the ratio can be increased from
the standard model prediction of 2.49% to 4.91% (2.99%) in the model III (II).
Consequently, the value of and can be decreased simultaneously
in the model III. The central value of will be lowered slightly by
about 0.003, but the ratio can be reduced significantly from the
theoretical prediction of in the SM to , for GeV, respectively. We find that
the predicted and the measured now agree within roughly one
standard deviation after taking into account the effects of gluonic charged
Higgs penguins in the model III with a relatively light charged Higgs boson.Comment: 25 pages, Latex file, axodraw.sty, 6 figures. Final version to be
published in Phys.Rev.
Theoretical study of lepton events in the atmospheric neutrino experiments at SuperK
Super-Kamiokande has reported the results for the lepton events in the
atmospheric neutrino experiment. These results have been presented for a 22.5kT
water fiducial mass on an exposure of 1489 days, and the events are divided
into sub-GeV, multi-GeV and PC events. We present a study of nuclear medium
effects in the sub-GeV energy region of atmospheric neutrino events for the
quasielastic scattering, incoherent and coherent pion production processes, as
they give the most dominant contribution to the lepton events in this energy
region. We have used the atmospheric neutrino flux given by Honda et al. These
calculations have been done in the local density approximation. We take into
account the effect of Pauli blocking, Fermi motion, Coulomb effect,
renormalization of weak transition strengths in the nuclear medium in the case
of the quasielastic reactions. The inelastic reactions leading to production of
leptons along with pions is calculated in a - dominance model by
taking into account the renormalization of properties in the nuclear
medium and the final state interaction effects of the outgoing pions with the
residual nucleus. We present the results for the lepton events obtained in our
model with and without nuclear medium effects, and compare them with the Monte
Carlo predictions used in the simulation and the experimentally observed events
reported by the Super-Kamiokande collaboration.Comment: 23 pages, 13 figure
Effect of temperature to the properties of sago starch
Recently, the importance of sago starch has increased, as it has become one of the
main economically important agricultural crops to the most Southeast Asia countries. In the
present work, an analysis on drying process of sago starch (Metroxylon sagu Rottb.) underwent
various temperature has been made by using four empirical equations. The main goal of this
analysis is to suggest the most accurate equation, in order to model and simulate the
mechanical drying of sago starch. The experimental investigations were carried out in a gravity
convection lab oven; and ±50g of sago starch (sample heights of 1 cm) was dried through four
different temperatures, which were 50, 60, 70 and 80ÂșC. The effect of drying temperature on
the drying kinetics, as well as various qualities attributes of sago starch, such as microstructure,
colour and functional properties were investigated. The results suggested that drying
temperature has significant effect on sago starch drying kinetic; therefore, drying temperature
would be the basis to select drying condition. Meanwhile, it was found that the various drying
temperature ranging from 50 to 80ÂșC affected the product quality especially in term of colour
Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble
The influenza virus subtype H5N1 has raised concerns of a possible human pandemic threat because of its high virulence and mutation rate. Although several approved anti-influenza drugs effectively target the neuraminidase, some strains have already acquired resistance to the currently available anti-influenza drugs. In this study, we present the synergistic application of extended explicit solvent molecular dynamics (MD) and computational solvent mapping (CS-Map) to identify putative âhot spotsâ within flexible binding regions of N1 neuraminidase. Using representative conformations of the N1 binding region extracted from a clustering analysis of four concatenated 40-ns MD simulations, CS-Map was utilized to assess the ability of small, solvent-sized molecules to bind within close proximity to the sialic acid binding region. Mapping analyses of the dominant MD conformations reveal the presence of additional hot spot regions in the 150- and 430-loop regions. Our hot spot analysis provides further support for the feasibility of developing high-affinity inhibitors capable of binding these regions, which appear to be unique to the N1 strain
Special Libraries, April 1933
Volume 24, Issue 3https://scholarworks.sjsu.edu/sla_sl_1933/1002/thumbnail.jp
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