526 research outputs found
Revised geological maps of Darlington based on new borehole information: explanation and description
The geology of the Darlington area has been revised based on the interpretation of new borehole information and a re-examination of archival data. The Permian Zechstein Group has been mapped through the district where it forms a series of easterly-dipping formations. These strata have been folded and an easterly-plunging syncline, faulted on its southern side, is mapped through the town of Darlington. This fold structure is partially modified by the dissolution of gypsum in the sequence resulting in the partial collapse and foundering of the strata. A series of maps is presented showing the revised geology, rockhead, drift thickness and the thickness of the gypsum sequence present at two horizons; the Hartlepool Anhydrite (present in the Edlington Formation) and the Billingham Anhydrite (present in the Roxby Formation). A series of five structure contour maps are presented illustrating the fold and fault structure of the area
Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries
<p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth muscle cell proliferation and migration and neointimal macrophage content, effects associated with the inhibition of MCP-1/CCL2 production. The aim of the current study was to evaluate the efficacy of bindarit on in-stent stenosis in the preclinical porcine coronary stent model.</p>
<p><b>Methods and Results:</b> One or 2 bare metal stents (Multi-Link Vision, 3.5 mm) were deployed (1:1.2 oversize ratio) in the coronary arteries of 42 pigs (20 bindarit versus 22 controls). Bindarit (50 mg/kg per day) was administered orally from 2 days before stenting until the time of euthanasia at 7 and 28 days. Bindarit caused a significant reduction in neointimal area (39.4%, P<0.001, n=9 group), neointimal thickness (51%, P<0.001), stenosis area (37%, P<0.001), and inflammatory score (40%, P<0.001) compared with control animals, whereas there was no significant difference in the injury score between the 2 groups. Moreover, treatment with bindarit significantly reduced the number of proliferating cells (by 45%, P<0.05; n=6 group) and monocyte/macrophage content (by 55%, P<0.01; n=5â6 group) in stented arteries at day 7 and 28, respectively. These effects were associated with a significant (P<0.05) reduction of MCP-1 plasma levels at day 28. In vitro data showed that bindarit (10â300 micromol/L) reduced tumor necrosis factor-alpha (50 ng/mL)âinduced pig coronary artery smooth muscle cell proliferation and inhibited MCP-1 production.</p>
<p><b>Conclusion:</b> Our results show the efficacy of bindarit in the prevention of porcine in-stent stenosis and support further investigation for clinical application of this compound.</p>
Kondo Effect of Quantum Dots in the Quantum Hall Regime
Quantum dots in the quantum Hall regime can have pairs of single Slater
determinant states that are degenerate in energy. We argue that these pairs of
many body states may give rise to a Kondo effect which can be mapped into an
ordinary Kondo effect in a fictitious magnetic field. We report on several
properties of this Kondo effect using scaling and numerical renormalization
group analysis. We suggest an experiment to investigate this Kondo effect.Comment: To appear in Phys. Rev. B (5 pages, 4 figures); references added;
several changes in tex
Relativistic corrections in magnetic systems
We present a weak-relativistic limit comparison between the Kohn-Sham-Dirac
equation and its approximate form containing the exchange coupling, which is
used in almost all relativistic codes of density-functional theory. For these
two descriptions, an exact expression of the Dirac Green's function in terms of
the non-relativistic Green's function is first derived and then used to
calculate the effective Hamiltonian, i.e., Pauli Hamiltonian, and effective
velocity operator in the weak-relativistic limit. We point out that, besides
neglecting orbital magnetism effects, the approximate Kohn-Sham-Dirac equation
also gives relativistic corrections which differ from those of the exact
Kohn-Sham-Dirac equation. These differences have quite serious consequences: in
particular, the magnetocrystalline anisotropy of an uniaxial ferromagnet and
the anisotropic magnetoresistance of a cubic ferromagnet are found from the
approximate Kohn-Sham-Dirac equation to be of order , whereas the
correct results obtained from the exact Kohn-Sham-Dirac equation are of order
. We give a qualitative estimate of the order of magnitude of these
spurious terms
New exact solution of Dirac-Coulomb equation with exact boundary condition
It usually writes the boundary condition of the wave equation in the Coulomb
field as a rough form without considering the size of the atomic nucleus. The
rough expression brings on that the solutions of the Klein-Gordon equation and
the Dirac equation with the Coulomb potential are divergent at the origin of
the coordinates, also the virtual energies, when the nuclear charges number Z >
137, meaning the original solutions do not satisfy the conditions for
determining solution. Any divergences of the wave functions also imply that the
probability density of the meson or the electron would rapidly increase when
they are closing to the atomic nucleus. What it predicts is not a truth that
the atom in ground state would rapidly collapse to the neutron-like. We
consider that the atomic nucleus has definite radius and write the exact
boundary condition for the hydrogen and hydrogen-like atom, then newly solve
the radial Dirac-Coulomb equation and obtain a new exact solution without any
mathematical and physical difficulties. Unexpectedly, the K value constructed
by Dirac is naturally written in the barrier width or the equivalent radius of
the atomic nucleus in solving the Dirac equation with the exact boundary
condition, and it is independent of the quantum energy. Without any divergent
wave function and the virtual energies, we obtain a new formula of the energy
levels that is different from the Dirac formula of the energy levels in the
Coulomb field.Comment: 12 pages,no figure
Quantum trajectory approach to stochastically-induced quantum interference effects in coherently-driven two-level atoms
Stochastic perturbation of two-level atoms strongly driven by a coherent
light field is analyzed by the quantum trajectory method. A new method is
developed for calculating the resonance fluorescence spectra from numerical
simulations. It is shown that in the case of dominant incoherent perturbation,
the stochastic noise can unexpectedly create phase correlation between the
neighboring atomic dressed states. This phase correlation is responsible for
quantum interference between the related transitions resulting in anomalous
modifications of the resonance fluorescence spectra.Comment: paper accepted for publicatio
Cosmic Density Perturbations from Late-Decaying Scalar Condensations
We study the cosmic density perturbations induced from fluctuation of the
amplitude of late-decaying scalar condensations (called \phi) in the scenario
where the scalar field \phi once dominates the universe. In such a scenario,
the cosmic microwave background (CMB) radiation originates to decay products of
the scalar condensation and hence its anisotropy is affected by the fluctuation
of \phi. It is shown that the present cosmic density perturbations can be
dominantly induced from the primordial fluctuation of \phi, not from the
fluctuation of the inflaton field. This scenario may change constraints on the
source of the density perturbations, like inflation. In addition, a correlated
mixture of adiabatic and isocurvature perturbations may arise in such a
scenario; possible signals in the CMB power spectrum are discussed. We also
show that the simplest scenario of generating the cosmic density perturbations
only from the primordial fluctuation of \phi (i.e., so-called ``curvaton''
scenario) is severely constrained by the current measurements of the CMB
angular power spectrum if correlated mixture of the adiabatic and isocurvature
perturbations are generated.Comment: 31pages, 14figure
The Primordial Perturbation Spectrum from Various Expanding and Contracting Phases
In this paper, focusing on the case of single scalar field, we discuss
various expanding and contracting phases generating primordial perturbations,
and study the relation between the primordial perturbation spectrum from these
phases and the parameter w of state equation in details. Furthermore, we offer
an interesting classification for the primordial perturbation spectrum from
various phases, which may have important implications for building an early
universe scenario embedded in possible high energy theories.Comment: 5 pages, 3 eps figure
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