Computational support for early stage architectural design

The concepts underlying 'scenario-based' design are introduced. From the analysis of a number of struc-tured interviews with practicing designers, key design scenarios are identified. These scenarios are then generalised and outline guidelines developed for structuring early stage design

Population stratification and genetic association studies in South Asia

Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing contrary empirical evidence has been published. However, it is in populations where historical ethnic, religious and language barriers exist that community subdivisions will predictably exert greatest genetic effect, and influence the organization of association studies. In many of the populations of the Indian sub-continent, these basic population divisions are compounded by a strict tradition of intracommunity marriage and by marriage between close biological relatives. Data on the very significant levels of genetic diversity that characterize the populations of India and Pakistan, with some 50,000-60,000 caste and non-caste communities in India, and average first cousin marriage rates of 40%-50% in Pakistan, are presented and discussed. Under these circumstances, failure to explicitly control for caste/biraderi membership and the presence of consanguinity could seriously jeopardize, and may totally invalidate, the results of association/case control studies and clinical trials

Responsible design : a conceptual look at interdependent design–use dynamics

This article investigates the conceptual foundations of technological innovation and development projects that aim to bring ethical and social issues into the design stage. Focusing on the ethics and social impact of technological innovation and development has been somewhat of a trend lately, for instance in ELSA research and in such initiatives as the Dutch Responsible Innovation programme. I argue that in order to succeed in doing social responsible and ethical sound design, a proper understanding of the relation between technology and society is required. I propose to move away from an externalist framework, in which technology and society are depicted as being defined independently, towards an interdependent framework, where technology and society are regarded to be mutually defining. This move is necessary in order for such innovation projects not to reinforce outdated concepts about technology, which in the longer run will prove counterproductive to the actual aims of the projects themselves

Wave model for longitudinal dispersion: Application to the laminar-flow tubular reactor

The wave model for longitudinal dispersion, published elsewhere as an alternative to the commonly used dispersed plug-flow model, is applied to the classic case of the laminar-flow tubular reactor. The results are compared in a wide range of situations to predictions by the dispersed plug-flow model as well as to exact numerical calculations with the 2-D model of the reactor and to other available methods. In many practical cases, the solutions of the wave model agree closely with the exact data. The wave model has a much wider region of validity than the dispersed plug-flow model, has a distinct physical background, and is easier to use for reactor calculations. This provides additional support to the theory developed elsewhere. The properties and the applicability of the wave model to situations with rapidly changing concentration fields are discussed. Constraints to be satisfied are established to use the new theory with confidence for arbitrary initial and boundary conditions

Cross-national differences in the labour force attachment of mothers in Western and Eastern Europe

This paper examines cross-national differences in the labour force attachment of two specific subgroups of mothers: the stay-at-home mothers (homemakers) and those on maternity or parental leave. The justification for focusing on homemakers is that these women constitute an untapped source of labour and are among those who would need to join the labour market in order to reach the EU employment target. As to those on leave, their temporary absence from work means that they will soon be facing a time when they have to decide whether or not to return to the labour market. They are therefore also a key group to consider. In this paper, the characteristics and labour market intentions of these two subgroups of women are analysed using data from the Generations and Gender Survey (GGS) for ten countries: five Western European countries (Austria, Belgium, France, Germany and Italy), and five Eastern European countries (Bulgaria, Georgia, Lithuania, Romania and the Russian Federation). This paper is structured as follows. It first reviews the literature on women’s employment by focusing on both individual and macro-level factors, including values, education and family circumstances. It then moves on to a presentation of the data and methods, followed by the results of the data analysis. The paper concludes with a discussion of the results and their policy implications.

Social class inequalities in perinatal outcomes: Scotland 1980–2000

Objective: To examine social class inequalities in adverse perinatal events in Scotland between 1980 and 2000 and how these were influenced by other maternal risk factors. Design: Population based study using routine maternity discharge data. Setting: Scotland. Participants: All women who gave birth to a live singleton baby in Scottish hospitals between 1980 and 2000 (n = 1 282 172). Main outcome measures: Low birth weight (LBW), preterm birth, and small for gestational age (SGA). Results: The distribution of social class changed over time, with the proportion of mothers with undetermined social class increasing from 3.9% in 1980–84 to 14.8% in 1995–2000. The relative index of inequality (RII) decreased during the 1980s for all outcomes. The RII then increased between the early and late 1990s (LBW from 2.09 (95%CI 1.97, 2.22) to 2.43 (2.29, 2.58), preterm from 1.52 (1.44, 1.61) to 1.75 (1.65, 1.86), and SGA from 2.28 (2.14, 2.42) to 2.49 (2.34, 2.66) respectively). Inequalities were greatest in married mothers, mothers aged over 35, mothers taller than 164 cm, and mothers with a parity of one or more. Inequalities were also greater by the end of the 1990s than at the start of the 1980s for women of parity one or more and for mothers who were not married. Conclusion: Despite decreasing during the 1980s, inequalities in adverse perinatal outcomes increased during the 1990s in all strata defined by maternal characteristics

An Exponentially Convergent Nonpolynomial Finite Element Method for Time-Harmonic Scattering from Polygons

In recent years nonpolynomial finite element methods have received increasing attention for the efficient solution of wave problems. As with their close cousin the method of particular solutions, high efficiency comes from using solutions to the Helmholtz equation as basis functions. We present and analyze such a method for the scattering of two-dimensional scalar waves from a polygonal domain that achieves exponential convergence purely by increasing the number of basis functions in each element. Key ingredients are the use of basis functions that capture the singularities at corners and the representation of the scattered field towards infinity by a combination of fundamental solutions. The solution is obtained by minimizing a least-squares functional, which we discretize in such a way that a matrix least-squares problem is obtained. We give computable exponential bounds on the rate of convergence of the least-squares functional that are in very good agreement with the observed numerical convergence. Challenging numerical examples, including a nonconvex polygon with several corner singularities, and a cavity domain, are solved to around 10 digits of accuracy with a few seconds of CPU time. The examples are implemented concisely with MPSpack, a MATLAB toolbox for wave computations with nonpolynomial basis functions, developed by the authors. A code example is included

Distribution of trace elements and total organic carbon in surface sediments of the Sulu and Sulawesi Seas (Taburan Unsur Surih dan Organik Karbon di permukaan sedimen di Laut Sulu dan Sulawesi)

The concentrations of TOC, Al, Fe, Mn, Pb, Cu, Ni, Co and Cr in 27 surface sediments have been determined from the Sulu and Sulawesi Sesa during the ‘Saintifik Perdana 2009’ expedition cruise from 18 June to 1 August 2009. Sampling was conducted to elucidate concentrations and spatial distributions throughout the study area. The samples were digested using a total digestion technique and the concentrations were determined using the ICP-MS. The distribution of trace elements fluctuated with stations and water depth, but showed high metal concentrations in some locations such as Marudu Bay, Sandakan and Darvel Bay. The concentrations of trace elements were mostly lower than the earth’s mean crust and the world’s mean sediments with the exception of a few trace elements in certain stations. The Geoaccumulation Index (Igeo) was calculated and the results showed that Ni are in class 1 (unpolluted to moderately polluted) while other trace elements are considered unpolluted. It can therefore be concluded that the Sulu and Sulawesi Seas are unpolluted and pristin

Safety implications of a pedestrian protection system - the driver's point of view

Pedestrians can sustain fatal injuries, even in low-speed collisions. Active pedestrian protection systems, such as an Active Bonnet, have been shown to mitigate the outcome of a collision. The study reported here aimed to discover whether such a system could have any negative impacts on the driver. One of the characteristics of the Active Bonnet is that, when deployed, it partially occludes the driver’s visual field. This driving simulator study quantified the amount of disruption to normal driving when the system is deployed, for drivers of three different heights. Curved and straight sections of road were simulated and occlusion time varied between 0.5 seconds and 4 seconds. In general, drivers’ reaction to the deployment of the bonnet was to decrease their speed; this was most noticeable for drivers at the lowest eye-height both in the straight and curved sections of road. On straight sections of road, drivers were able to maintain vehicle speed and lateral control for up to three seconds of partial occlusion of the visual field. For curved sections, this upper threshold was found to be only two seconds, reflecting the higher workload in the curved sections. When occlusion was lifted, drivers tended to then deviate in lane – a possible “panic” effect. As drivers became more familiar with the system, they applied the brakes less. In conclusion, according to the scenarios tested in this study, drivers appear to be able to cope with partial occlusions of two seconds or less and there is some evidence that a panic reaction can be lessened by familiarisation

Are You Used To It Yet? Braking Performance and Adaptation in a Fixed-base Driving Simulator.

During braking-to-stop manoeuvres in a fixed-base driving simulator, the paucity of visual and vestibular cues can lead to driver misperception and produce different patterns of braking response between real and simulated driving. For these reasons, drivers must adapt their behaviour in a simulator to affect a comfortable and efficient braking manoeuvre. Such behavioural adaptation is likely to have negative consequences by increasing a driver’s attentional demand. In this study, 48 participants underwent a series of braking-to-stop manoeuvres in an instrumented vehicle on a test-track. Each participant was instructed to drive at 40mph. A set of traffic lights, on occasions, changed to red as the vehicle was 58m from the lights. Deceleration profiles provided the baseline data. The same scenario was modelled in a fixed-base driving simulator. Two groups, each of 24 participants, one familiar with the simulator from previous investigations and one with no prior simulator experience, underwent the simulated traffic light scenario ten times. This paper suggests a method of objectively assessing driver braking performance between the real and simulated environments. Results appear to suggest that in as little as five or six practice stops drivers can adapt their simulator driving style to closely match that observed in a real vehicle on a test track. However, any process of adaptation from prior exposure to the simulator is short-lived