9 research outputs found

    Growth hormone releasing hormone

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    Contains fulltext : mmubn000001_05566542x.pdf (publisher's version ) (Open Access)Promotores : A. Smals en P. Kloppenborg154 p

    Stilboestrol pretreatment of children with short stature does not affect the growth hormone response to growth hormone releasing hormone

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    Oestrogens are known to enhance both basal and stimulated GH secretion. To examine whether this effect is mediated through the hypothalamus or the pituitary we performed insulin tolerance and GH-releasing hormone (GHRH) tests with and without oestrogen priming in a group of 14 short children. Pretreatment with stilboestrol increased basal levels of GH and both peak and incremental levels during insulin hypoglycaemia. In contrast, there was no effect of stilboestrol priming on the GH response to either an i.v. bolus of 100 μg or 0.1 μg/kg (range 2-6 μg) of GHRH. The children had significantly higher GH responses to an unprimed GHRH than unprimed insulin tolerance test. We conclude stilboestrol priming acts through the hypothalamus presumably by increasing endogenous GHRH release, and that short children with a subnormal GH response to insulin hypoglycaemia show a greater response to GHRH; this suggests the presence of a hypothalamic cause for their decreased GH secretion

    Growth hormone (GH) and reproduction: a review

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    International audienceInteraction between growth and reproduction occurs in many vertebrates and is particularly obvious at certain stages of the life cycle in fish. Endocrine interactions between the gonadotropic axis and the somatotropic axis are described, the potential role of GH being emphasised. A comparative analysis of these phenomena in mammals, amphibians and fish, suggests a specific role of GH in the physiology of puberty, gametogenesis and fertility. It also shows the original contribution made by studies on the fish model in this field of investigations.Les intéractions entre les fonctions de croissance et de reproduction mises en evidence chez de nombreux vertébrés, sont particulièrement aigües à certainesé tapes du cycle vital des poissons. Nous dérivons les interactions endocrines existant entre les axes somatrope et gonadotrope en insistant sur le role joué par l'hormone de croissance (GH). L'analyse comparée de ces phénomènes chez les mammifères, les poissons et les amphibiens permet de suggérer que la GH joue un rôle spécifique dans la physiologie de la puberté, la gametogenèse et la fertilité Nous mettons en évidence l'apport original des études effectuées sur le module poisson dans ce champ d'investigation.

    GROWTH HORMONE NEUROREGULATION AND ITS ALTERATIONS IN DISEASE STATES

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