55 research outputs found
Mapa do desenvolvimento da pecuária leiteira no estado de Minas Gerais, Brasil: nova abordagem na pecuária para integração espacial de variáveis produtivas
A low resolution model for the interaction of G proteins with G protein-coupled receptors
Conformational Properties of Loops of G Protein Coupled Receptors: Relevance for Biological Function and for Membrane Protein Folding
Ligand-induced endocytosis and nuclear localization of angiotensin II receptors expressed in CHO cells
A construct (AT1R-NF) containing a "Flag" sequence added to the N-terminus of the rat AT1 receptor was stably expressed in Chinese hamster ovary cells and quantified in the cell membrane by confocal microscopy after reaction with a fluorescein-labeled anti-Flag monoclonal antibody. Angiotensin II bound to AT1R-NF and induced endocytosis with a half-time of 2 min. After 60-90 min, fluorescence accumulated around the cell nucleus, suggesting migration of the ligand-receptor complex to the nuclear membrane. Angiotensin antagonists also induced endocytosis, suggesting that a common step in the transduction signal mechanism occurring after ligand binding may be responsible for the ligand-receptor complex internalization
Synthesis and Interaction with Membranes of a Spin Labeled Pentadecapeptide Contained in the Sequence of an Angiotensin II Receptor
Synthesis of a Spin Labeled Fragment of a Putative Receptor of the Peptide Hormone Angiotensin II. Conformational Properties in Solution and Binding to Membranes
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