Hydrological factors influencing sediment concentration fluctuations in small drainage basins

Although sediment concentrations measured in two contrasting streams in East Yorkshire fluctuate in response to similar hydrological factors, the effectiveness of these factors reflects the environmental characteristics of the drainage basins. Consequently, regression relationships used to predict sediment concentrations in individual streams are not directly applicable outside the region in which they were developed. The sensitivity of sediment concentration variations to environmental conditions makes long term estimates of denudation of limited value

Chemical Time Bombs: Linkages to Scenarios of Socioeconomic Development (CTB Basic Document 2)

The definition of a chemical time bomb (CTB), as provided in the first document of this series is "a concept that refers to a chain of events resulting in the delayed and sudden occurrence of harmful effects due to the mobilization of chemicals stored in soils and sediments in response to slow alterations of the environment." The theme of this second report was conceived at a workshop in the Netherlands in 1990. It was decided that chemical time bombs must be understood not only in terms of how they are triggered in the environment, but also in terms of the anthropogenic activities that are linked to the triggers. For example, a change in redox potential is a CTB trigger, and activities such as draining of wetlands an implementing sewage treatment have a major influence on redox potential. Thus, this report attempts to connect specific human activities to environmental disturbances that can stimulate CTNB phenomena. These connections are made for a range of activities, and matrices linking activities to effects are presented. The analysis is taken a step further by constructing scenarios, of land-use changes for example, and assessing their impacts with respect to CTBs. Thus, scenarios are used here not as a way of predicting the future, but rather for the purpose of presenting possible alternatives against which the risk of CTB events can be assessed. This publication is the second in a series of IIASA publications on Chemical Time Bombs. The first, entitled "Chemical Time Bombs: Definition, Concepts, and Examples," was published in 1991. The next publication in the series will discuss CTBs in landfills and contaminated lands

Current Wildland Fire Patterns and Challenges in Europe: A Synthesis of National Perspectives

Changes in climate, land use, and land management impact the occurrence and severity of wildland fires in many parts of the world. This is particularly evident in Europe, where ongoing changes in land use have strongly modified fire patterns over the last decades. Although satellite data by the European Forest Fire Information System provide large-scale wildland fire statistics across European countries, there is still a crucial need to collect and summarize in-depth local analysis and understanding of the wildland fire condition and associated challenges across Europe. This article aims to provide a general overview of the current wildland fire patterns and challenges as perceived by national representatives, supplemented by national fire statistics (2009–2018) across Europe. For each of the 31 countries included, we present a perspective authored by scientists or practitioners from each respective country, representing a wide range of disciplines and cultural backgrounds. The authors were selected from members of the COST Action “Fire and the Earth System: Science & Society” funded by the European Commission with the aim to share knowledge and improve communication about wildland fire. Where relevant, a brief overview of key studies, particular wildland fire challenges a country is facing, and an overview of notable recent fire events are also presented. Key perceived challenges included (1) the lack of consistent and detailed records for wildland fire events, within and across countries, (2) an increase in wildland fires that pose a risk to properties and human life due to high population densities and sprawl into forested regions, and (3) the view that, irrespective of changes in management, climate change is likely to increase the frequency and impact of wildland fires in the coming decades. Addressing challenge (1) will not only be valuable in advancing national and pan-European wildland fire management strategies, but also in evaluating perceptions (2) and (3) against more robust quantitative evidence

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease