8 research outputs found
Influence of single nucleotide polymorphisms (SNPs) within genes encoding platelet glycoprotein receptors and blood-coagulation factors on embolic risk in patients with infective endocarditis (IE)
Attitude Determination Using Ambiguous GNSS Phase Measurements and Absolute Angular Rate Measurements
Outcomes, survival analysis and the role of kidney damage in modeling the risk of adverse outcome in patients with infective endocarditis
Hypercoagulation detected by routine and global laboratory hemostasis assays in patients with infective endocarditis
Background Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess the coagulation and platelet state in IE implementing a wide range of standard and global laboratory assays. We also aim to determine whether prothrombotic genetic polymorphisms play any role in embolization and mortality in IE patients. Methods 37 patients with IE were enrolled into the study. Coagulation was assessed using standard coagulation assays (activated partial thromboplastin time (APTT), prothrombin, fibrinogen, D-dimer concentrations) and integral assays (thromboelastography (TEG) and thrombodynamics (TD)). Platelet functional activity was estimated by flow cytometry. Single nuclear polymorphisms of coagulation system genes were studied. Results Fibrinogen concentration and fibrinogen-dependent parameters of TEG and TD were increased in patients indicating systemic inflammation. In majority of patients clot growth rate in thrombodynamics was significantly shifted towards hypercoagulation in consistency with D-dimers elevation. However, in some patients prothrombin, thromboelastography and thrombodynamics were shifted towards hypocoagulation. Resting platelets were characterized by glycoprotein IIb-IIIa activation and degranulation. In patients with fatal IE, we observed a significant decrease in fibrinogen and thrombodynamics. In patients with embolism, we observed a significant decrease in the TEG R parameter. No association of embolism or mortality with genetic polymorphisms was found in our cohort. Conclusions Our findings suggest that coagulation in patients with infective endocarditis is characterized by general hypercoagulability and platelet pre-activation. Some patients, however, have hypocoagulant coagulation profile, which presumably can indicate progressing of hypercoagulation into consumption coagulopathy. © 2021 Koltsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Comparison of Time Scales by the Common-View Method Using GLONASS Measurements and Taking into Account the Integer Property of Phase Ambiguities
GLONASS
The Global’naya Navigatsionnaya Sputnikova Sistema
(GLONASS) is a global navigation satellite
system developed by the Russian Federation.
Similar to its US counterpart, the NAVSTAR global
positioning system (GPS), GLONASS provides dualfrequency
L-band navigation signals for civil and
military navigation. Initiated in the 1980s, the
system first achieved its full operational capability
in 1995. Following a temporary degradation,
the nominal constellation of 24 satellites was ultimately
reestablished in 2011 and the system has
been in continued service since then. This chapter
describes the architecture and operations of
GLONASS and discusses its current performance. In
addition, the planned evolution of the space and
ground segment are outlined