18 research outputs found
Time dependent viscoelastic rheological response of pure, modified and synthetic bituminous binders
Bitumen is a viscoelastic material that exhibits both elastic and viscous components of response and displays both a temperature and time dependent relationship between applied stresses and resultant strains. In addition, as bitumen is responsible for the viscoelastic behaviour of all bituminous materials, it plays a dominant role in defining many of the aspects of asphalt road performance, such as strength and stiffness, permanent deformation and cracking. Although conventional bituminous materials perform satisfactorily in most highway pavement applications, there are situations that require the modification of the binder to enhance the properties of existing asphalt material. The best known form of modification is by means of polymer modification, traditionally used to improve the temperature and time susceptibility of bitumen. Tyre rubber modification is another form using recycled crumb tyre rubber to alter the properties of conventional bitumen. In addition, alternative binders (synthetic polymeric binders as well as renewable, environmental-friendly bio-binders) have entered the bitumen market over the last few years due to concerns over the continued availability of bitumen from current crudes and refinery processes. This paper provides a detailed rheological assessment, under both temperature and time regimes, of a range of conventional, modified and alternative binders in terms of the materials dynamic (oscillatory) viscoelastic response. The rheological results show the improved viscoelastic properties of polymer- and rubber-modified binders in terms of increased complex shear modulus and elastic response, particularly at high temperatures and low frequencies. The synthetic binders were found to demonstrate complex rheological behaviour relative to that seen for conventional bituminous binders
Features of the radical polymerization of styrene and methacrylates in the presence of cobalt-oximes
Role of the inelastic transfer channel in elastic 16O + 12C scattering over a wide range of energies
Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ΅Ρ ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΉ Π½Π° ΡΠΎΠ½Π΅ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½ΠΈΠ²ΠΎΠ»ΡΠΌΠ°Π±ΠΎΠΌ
Active implementation of immune checkpoint inhibitors into oncology practice leads to an increase in numbers of observed immune-mediated adverse events, including various endocrinopathies. The focus is on multiple endocrine gland involvement because their predictors are unclear.
The paper describes a clinical case of a patient with central cancer of the right lung, who had been administered immune therapy with anti-PD-1 monoclonal antibody (nivolumab). Under this treatment, three endocrine immune-mediated adverse events developed without any concomitant problems from other organs and body systems. The most interesting was the occurrence of adrenal insufficiency and fulminant diabetes mellitus, while, unlike hypothyroidism, which also developed in this patient, those two have been significantly less often described and up to now their incidence, prevalence and association with a certain subgroup of immune checkpoint inhibitors have not been identified. Despite multiple endocrine organ involvement and taking into account positive effects of the anti-tumor treatment, as well as titration of the corresponding hormonal replacement therapy, treatment with nivolumab was continued.
Patients treated with immune checkpoint inhibitors require a multidisciplinary team approach including an endocrinologist, because of the potential multiple endocrinopathies, including life-threatening.ΠΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΡΠΎΡΠ΅ΠΊ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° Π² ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΠΈΡΠ»Π° Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΡ
ΠΈΠΌΠΌΡΠ½ΠΎΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ²Π»Π΅Π½ΠΈΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΉ. Π ΡΠΎΠΊΡΡΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΡΠ»ΡΡΠ°ΠΈ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΏΠΎΠ»ΠΈΠ³Π»Π°Π½Π΄ΡΠ»ΡΡΠ½ΡΡ
ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΏΠΎ ΠΏΡΠΈΡΠΈΠ½Π΅ ΠΈΡ
Π½Π΅ΡΡΠ½ΡΡ
ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ².
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Ρ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΠΏΡΠ°Π²ΠΎΠ³ΠΎ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΠΊΠΎΡΠΎΡΠΎΠΌΡ Π±ΡΠ»Π° Π½Π°Π·Π½Π°ΡΠ΅Π½Π° ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ Π°Π½ΡΠΈ-PD-1-ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠΌ Π°Π½ΡΠΈΡΠ΅Π»ΠΎΠΌ (Π½ΠΈΠ²ΠΎΠ»ΡΠΌΠ°Π±). ΠΠ° ΡΠΎΠ½Π΅ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°Π·Π²ΠΈΠ»ΠΎΡΡ ΡΡΠΈ ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ
ΠΈΠΌΠΌΡΠ½ΠΎΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ²Π»Π΅Π½ΠΈΡ Π±Π΅Π· ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π΄ΡΡΠ³ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ Π½Π°Π΄ΠΏΠΎΡΠ΅ΡΠ½ΠΈΠΊΠΎΠ²ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΡΠ»ΡΠΌΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π±Π΅ΡΠ°, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π² ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ Π³ΠΈΠΏΠΎΡΠΈΡΠ΅ΠΎΠ·Π°, ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·Π²ΠΈΠ²ΡΠ΅Π³ΠΎΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΎΠ½ΠΈ ΠΎΠΏΠΈΡΡΠ²Π°ΡΡΡΡ Π·Π½Π°ΡΠΈΠΌΠΎ ΡΠ΅ΠΆΠ΅ ΠΈ Π½Π° Π΄Π°Π½Π½ΡΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ Π½Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠ°ΡΡΠΎΡΠ° ΠΈΡ
Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ ΠΈ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΡ Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠΉ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠΎΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΡΠΎΡΠ΅ΠΊ. ΠΠ΅Π²Π·ΠΈΡΠ°Ρ Π½Π° ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΎΡΠ³Π°Π½ΠΎΠ² ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, Ρ ΡΡΠ΅ΡΠΎΠΌ Π½Π°Π»ΠΈΡΠΈΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π² ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΈ ΠΏΠΎΠ΄Π±ΠΎΡΠ° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π½ΠΈΠ²ΠΎΠ»ΡΠΌΠ°Π±ΠΎΠΌ Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΎ.
ΠΠ°ΡΠΈΠ΅Π½ΡΡ, ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΡΠΎΡΠ΅ΠΊ, Π½ΡΠΆΠ΄Π°ΡΡΡΡ Π² ΠΌΡΠ»ΡΡΠΈΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΠΎΠΌ Π²Π΅Π΄Π΅Π½ΠΈΠΈ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠ»ΠΎΠ³Π°, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
(Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΆΠΈΠ·Π½Π΅ΡΠ³ΡΠΎΠΆΠ°ΡΡΠΈΡ
) ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΉ
Harmonic analysis of the repolarization processes in a Rb2ZnCl4 crystal near the temperature of domain structure freezing (T* β 150 K)
Investigation of statistical characteristics of interaction between the low-frequency oscillations in heart rate variability and peripheral microcirculation in healthy subjects and myocardial infarction patients
Objective. This study compares the statistical characteristics of interaction between 0.1 Hz oscillations in heart rate variability (HRV) and photoplethysmogram (PPG) in healthy subjects and myocardial infarction (Ml) patients. Material and methods. We studied 23 healthy subjects (20 men and 3 women aged 26Β±3 years) and 23 patients (12 men and 11 women aged 52Β±4 years) at about one month after Ml. The 10-minute signals of simultaneously recorded cardioin-tervalogram (CIG) and PPG were studied. We calculated the total percentage of phase synchronization between the studied 0.1 Hz oscillations and estimated the distribution functions of duration of synchronous and non-synchronous epochs, the variability of basic frequency of oscillations, and variance of phase noises in 0.1 Hz oscillations in HRV and PPG. Results. The total percentage of phase synchronization between 0.1 Hz oscillations is significantly greater in healthy subjects than in Ml patients (47Β±3% and 26Β±4%, respectively). Significant difference between these two groups in the distribution of duration of synchronous and non-synchronous epochs was not revealed. The Ml patients had greater variance between the basic frequencies of 0.1 Hz oscillations in HRV and PPG than healthy subjects. This phenomenon correlates with the increased level of phase noises in the records of Ml patients. Conclusion. The quality of synchronization between 0.1 Hz oscillations in HRV and PPG is associated with the strength of influence of external factors (noises) and variability of the basic frequency of these oscillations