Non-surgical treatment of massive traumatic corpus callosum hematoma after blunt head injury: A case report

Massive hematoma of the corpus callosum caused by blunt head trauma is an extremely rare lesion. Most frequent traumatic lesions involve the corpus callosum are diffuse axonal injuries. They might be associated with small hemorrhagic foci in the hemispheric and brain stem white matter, intraventricular hemorrhages, subarachnoid hemorrhages, traumatic lesions of the septum pellucidum and fornix. Many cases of corpus callosum injury present with permanent disconnection syndrome. We present a case of a 32-year-old female suffered blunt head trauma resulted in massive corpus callosum hematoma which was managed non-surgically. The patient initially had a reduced conscious level and symptoms of disconnection syndrome, and significant recovery was observed at 6 months follow up

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Testing Disjointness of Private Datasets

Two parties, say Alice and Bob, possess two sets of elements that belong to a universe of possible values and wish to test whether these sets are disjoint or not. In this paper we consider the above problem in the setting where Alice and Bob wish to disclose no information to each other about their sets beyond the single bit: "whether the intersection is empty or not." This problem has many applications in commercial settings where two mutually distrustful parties wish to decide with minimum possible disclosure whether there is any overlap between their private datasets. We present three protocols that solve the above problem that meet di#erent e#ciency and security objectives and data representation scenarios. Our protocols are based on Homomorphic encryption and in our security analysis, we consider the semi-honest setting as well as the malicious setting. Our most e#cient construction for a large universe in terms of overall communication complexity uses a new encryption primitive that we introduce called "superposed encryption." We formalize this notion and provide a construction that may be of independent interest