Practice Schedule And The Learning Of Motor Skills In Children And Adults: Teaching Implications

Understanding how motor skills are learned influences how one teaches effective motor skill attainment. Educators must ask, “Does repetitive practice of the same task make for better performance or does contextual variability (random practice) offer some benefit when learning motor skills?” Studies on the effects of Contextual Interference may provide some insight. Contextual interference (CI) studies typically use simple tasks involving movements already acquired by adults, which may account for random practice benefits. In contrast, children do not consistently demonstrate CI effects, as tasks usually require acquisition of a new movement pattern. In this experiment, adults and children ((8-10 yrs old) threw a Frisbee to targets for 54 trials under random or blocked conditions. Having had considerable throwing experience with other throwing objects, adults were expected to benefit from random practice. For children, a blocked practice advantage was predicted as it provides for devising and stabilizing a suitable movement pattern. Retention/retraining trials were administered 30 minutes after acquisition and seven days later. Two transfer tests were given after the delayed retention test: (a) same throwing object/different target distances (SODT), which required re-scaling the practiced movement, and (b) different throwing object (ropeball)/same target distances (DOST) which required a new movement pattern. Throwing accuracy was measured by absolute error from the target. Both age groups showed a blocked practice benefit on retention and SODT transfer tests. Findings from this experiment suggest that task variables and stage of learning are important determinants of CI effects and thus should influence how we teach motor skill attainment

Agitation behaviour and heart rate of dairy cows with and without calf-contact during different stimuli in the parlour

Farmers who are interested to rear calves together with the dairy cows during the first weeks of life are confronted with problems of poor milk let-down during machine milking. Therefore it was investigated whether 3 calf-associated stimuli were capable to enhance milkability of the cows. In this contribution, the effect of the stimulations during milking on heart rate (HR) and agitation (rumination, posture of the head and behaviour during udder preparation)are presented. Olfactory (calf hair), tactile (teat massage) and acoustic(recorded calf calls)stimulation were tested on 15 dairy cows with permanent contact to their calves and 22 control cows. All cows were milked twice daily. Stimulation tests were conducted in 3 consecutive weeks during day 25–51 of lactation, each stimulus tested in 4 milkings versus 4 routine milkings. As HR was only measured at morning milkings there were only 2 repetitions per stimulus. Mixed models with the fixed factors stimulation (vs. routine milking), calf-contact, breed (German Red Pied vs. German Holstein) and parity (primiparous vs. pluriparous) and the random factor animal were applied for each parameter. Rumination and posture of the head were not influenced by any factor. Agitation behaviour and HR in the parlour were not affected by calf-contact. This questions stress as elicitor of problems with milk ejection. Tactile stimulation had an increasing, acoustic stimulation a decreasing effect on HR. German Red Pied showed more agitation behaviour during udder preparation and a higher HR in this phase compared to the German Holsteins. This could be due to differences in temperament or sensitivity to touching. According to expectations, primiparous cows showed more agitation during udder preparation than pluriparous, but this was not accompanied by an HR increase. The results did not indicate higher stress reactions in the parlour of dairy cows with calf contact. Acoustic stimulation led to a lower HR independent from calf-contact compared with HR at routine milking

Wenn Milchkühe ihre Kälber säugen - freier vs. Halbtagskontakt

The influence of three calf rearing systems on milk yield, milk composition, udder 18:00, n=11) and no damtheir dam after birth. In the 10th week of life contact dams and calves were physicallyseparated and had only visual contact. They were trained to drink from nipple buckets. In the 11th week of life thcontact. All calves were gradually weaned from milk until the 13th- cows and those gave less milk than-indicating disturbed milk ejection. Udder health was not affected. Nursed calves grew ut after separation there was a growth check. However, two weeks after weaning live weights of dam reared calves were still significantly higher Hence, our results suggest that half-day mother-calfcontact helps to decrease milk losses while calf development is still improved

Milchleistung, Milchfluss und Milchinhaltsstoffe von Kühen mit und ohne Kalbkontakt in Abhängigkeit von verschiedenen Stimulationsverfahren beim Melken

Farmers who are interested to rear calves together with the dairy cows during the first weeks of life are confronted with problems of poor milk let-down during machine milking. This study investigates the influence of three calf-associated stimuli during milking on milk yield, milk content and milk flow characteristics: olfactory (calf hair), tactile (teat massage) and acoustic (recorded calf calls) stimulation including 14 dairy cows with permanent contact to their calves (group KM) and 22 control cows (group M). All cows were milked twice daily. Stimulation tests were conducted in three consecutive weeks during day 25-51 of lactation, each stimulus tested in four milkings versus four milkings without stimulation. Mixed models with the fixed factors stimulation (vs. no stimulation), group, time of day, interaction stimulation*group and the random factor cows were applied for each stimulus. Stimulations had only minor effects on the measured parameters and did thus not improve the existing milkability of the dairy cows with and without calf contact. Differences between the groups were significant. KM-cows had a decreased milk yield of ca. 10 kg per milking and reduced fat content of about 1%. Also milk flow was lower than in M-cows. Further research on how to improve milk let-down of cows with calf contact should pay attention to the duration of pre-stimulation and the length of daily calf contact

Leiden behornte Milchkühe weniger unter leichtem bis moderatem Hitzestress als enthornte?

Es wird vermutetet, dass Hörner bei der Thermoregulation von Rindern eine Rolle spielen könnten. Deshalb wurde die Atemfrequenz, als Indikator für Hitzestress, von behornten und enthornten Europäischen Milchkühen, die gemeinsam in einer Herde im Stall gehalten wurden, erfasst. Die Gruppenzusammensetzung (N=7) war bezüglich Laktationsstand (35-354 d), Milchleistung (5,6-36,6 kg/d) und Fellfarbe balanciert. Die Atemfrequenz jedes Tieres wurde an fünf aufeinanderfolgenden Tagen durch eine Person erfasst. Der Temperature Humidity Index (THI) wurde alle 10 min. im Stall gemessen. Zur Datenanalyse wurde ein gemischtes Modell verwendet (zufälliger Faktor: Tier, fixe Faktoren: Hornstatus, THI). Der THI lag zwischen 71,9-81,5 (Mittel=75,9). Mit steigendem THI, stieg auch die Atemfrequenz an (Modellschätzwert=0,9, P=0,0341). Die Atemfrequenz lag zwischen 29,6-78,5 (Mittel=55,0). Der Hornstatus hatte keinen Einfluss auf die Atemfrequenz (P=0,5294). Im Stall hatte die Behornung keinen abschwächenden Effekt auf leichten bis moderaten Hitzestress

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients

Background and Purpose: The aim of this study was to elucidate the role of therapy-related cardiotoxicity in multiple sclerosis (MS) patients treated with mitoxantrone and to identify potential predictors for individual risk assessment. Methods: Within a multicenter retrospective cohort design, cardiac side effects attributed to mitoxantrone were analyzed in 639 MS patients at 2 MS centers in Germany. Demographic, disease, treatment, and follow-up data were collected from hospital records. Patients regularly received cardiac monitoring during the treatment phase. Results: None of the patients developed symptomatic congestive heart failure. However, the frequency of patients experiencing cardiac dysfunction of milder forms after mitoxantrone therapy was 4.1% (26 patients) among all patients. Analyses of the risk for cardiotoxicity revealed that cumulative dose exposure was the only statistically relevant risk factor associated with cardiac dysfunction. Conclusions: The number of patients developing subclinical cardiac dysfunction below the maximum recommended cumulative dose is higher than was initially assumed. Interestingly, a subgroup of patients was identified who experienced cardiac dysfunction shortly after initiation of mitoxantrone and who received a low cumulative dose. Therefore, each administration of mitoxantrone should include monitoring of cardiac function to enhance the treatment safety for patients and to allow for early detection of any side effects, especially in potential high-risk subgroups (as determined genetically)

Functional connectivity analysis using whole brain and regional network metrics in MS patients

In the present study we investigated brain network connectivity differences between patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HC) as derived from functional resonance magnetic imaging (fMRI) using graph theory. Resting state fMRI data of 18 RRMS patients (12 female, mean age ± SD: 42 ± 12.06 years) and 25 HC (8 female, 29.2 ± 5.38 years) were analyzed. In order to obtain information of differences in entire brain network, we focused on both, local and global network connectivity parameters. And the regional connectivity differences were assessed using regional network parameters. RRMS patients presented a significant increase of modularity in comparison to HC, pointing towards a network structure with densely interconnected nodes within one module, while the number of connections with other modules outside decreases. This higher decomposable network favours cost-efficient local information processing and promotes long-range disconnection. In addition, at the regional anatomical level, the network parameters clustering coefficient and local efficiency were increased in the insula, the superior parietal gyrus and the temporal pole. Our study indicates that modularity as derived from fMRI can be seen as a characteristic connectivity feature that is increased in MS patients compared to HC. Furthermore, specific anatomical regions linked to perception, motor function and cognition were mainly involved in the enhanced local information processing

Toward An Identity for the Field of Doctoral Education in Health Sciences

The Association of Doctoral Programs in Health Sciences (ADPHS) was informally established in November 2019, officially incorporated in August 2021, and is currently a 501(c)(3) non-profit organization comprised of the directors of member doctoral programs of health sciences. The ADPHS grew from informal discussions among program directors who agreed that a major problem in the field of doctoral education in health sciences was the lack of a clearly defined and easily articulable identity. The discussions led to the drafting of an informal and nonscientific survey used to help clarify the current health sciences education environment, relevant emerging trends, and the educational philosophies adopted by the directors of health sciences doctoral programs nationally. The results of the survey and follow-up discussions revealed a strong consensus among program directors that the field of doctorate education in health sciences is uniformly characterized by its interdisciplinary nature. In this position paper, we provide the rationale for the formal position of the ADPHS that the identity of the field of doctoral education in health sciences is based on its interdisciplinary approach to education

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity

<p>Abstract</p> <p>Background</p> <p>Two-photon laser scanning microscopy (TPLSM) has become a powerful tool in the visualization of immune cell dynamics and cellular communication within the complex biological networks of the inflamed central nervous system (CNS). Whereas many previous studies mainly focused on the role of effector or effector memory T cells, the role of naïve T cells as possible key players in immune regulation directly in the CNS is still highly debated.</p> <p>Methods</p> <p>We applied <it>ex vivo </it>and intravital TPLSM to investigate migratory pathways of naïve T cells in the inflamed and non-inflamed CNS. MACS-sorted naïve CD4+ T cells were either applied on healthy CNS slices or intravenously injected into RAG1 -/- mice, which were affected by experimental autoimmune encephalomyelitis (EAE). We further checked for the generation of second harmonic generation (SHG) signals produced by extracellular matrix (ECM) structures.</p> <p>Results</p> <p>By applying TPLSM on living brain slices we could show that the migratory capacity of activated CD4+ T cells is not strongly influenced by antigen specificity and is independent of regulatory or effector T cell phenotype. Naïve T cells, however, cannot find sufficient migratory signals in healthy, non-inflamed CNS parenchyma since they only showed stationary behaviour in this context. This is in contrast to the high motility of naïve CD4+ T cells in lymphoid organs. We observed a highly motile migration pattern for naïve T cells as compared to effector CD4+ T cells in inflamed brain tissue of living EAE-affected mice. Interestingly, in the inflamed CNS we could detect reticular structures by their SHG signal which partially co-localises with naïve CD4+ T cell tracks.</p> <p>Conclusions</p> <p>The activation status rather than antigen specificity or regulatory phenotype is the central requirement for CD4+ T cell migration within healthy CNS tissue. However, under inflammatory conditions naïve CD4+ T cells can get access to CNS parenchyma and partially migrate along inflammation-induced extracellular SHG structures, which are similar to those seen in lymphoid organs. These SHG structures apparently provide essential migratory signals for naïve CD4+ T cells within the diseased CNS.</p