Debye mass and heavy quark potential in a PNJL quark plasma

We calculate the Debye mass for the screening of the heavy quark potential in a plasma of massless quarks coupled to the temporal gluon background governed by the Polyakov loop potential within the PNJL model in RPA approximation. We give a physical motivation for a recent phenomenological fit of lattice data by applying the calculated Debye mass with its suppression in the confined phase due to the Polyakov-loop to a description of the temperature dependence of the singlet free energy for QCD with a heavy quark pair at infinite separation. We compare the result to lattice data.Comment: 6 pages, 1 figure, contribution to Proceedings of the 6th International Conference on "Critical Point and Onset of Deconfinement", to appear in Phys. At. Nucl., vol. 7

On the number of solutions of a transcendental equation arising in the theory of gravitational lensing

The equation in the title describes the number of bright images of a point source under lensing by an elliptic object with isothermal density. We prove that this equation has at most 6 solutions. Any number of solutions from 1 to 6 can actually occur.Comment: 26 pages, 12 figure

The UTMOST pulsar timing programme I: overview and first results

We present an overview and the first results from a large-scale pulsar timing programme that is part of the UTMOST project at the refurbished Molonglo Observatory Synthesis Radio Telescope (MOST) near Canberra, Australia. We currently observe more than 400 mainly bright southern radio pulsars with up to daily cadences. For 205 (8 in binaries, 4 millisecond pulsars) we publish updated timing models, together with their flux densities, flux density variability, and pulse widths at 843 MHz, derived from observations spanning between 1.4 and 3 yr. In comparison with the ATNF pulsar catalogue, we improve the precision of the rotational and astrometric parameters for 123 pulsars, for 47 by at least an order of magnitude. The time spans between our measurements and those in the literature are up to 48 yr, which allows us to investigate their long-term spin-down history and to estimate proper motions for 60 pulsars, of which 24 are newly determined and most are major improvements. The results are consistent with interferometric measurements from the literature. A model with two Gaussian components centred at 139 and $463~\text{km} \: \text{s}^{-1}$ fits the transverse velocity distribution best. The pulse duty cycle distributions at 50 and 10 per cent maximum are best described by log-normal distributions with medians of 2.3 and 4.4 per cent, respectively. We discuss two pulsars that exhibit spin-down rate changes and drifting subpulses. Finally, we describe the autonomous observing system and the dynamic scheduler that has increased the observing efficiency by a factor of 2-3 in comparison with static scheduling.Comment: 31 pages, 14 figures, 6 tables, accepted for publication in MNRA

The first interferometric detections of Fast Radio Bursts

We present the first interferometric detections of Fast Radio Bursts (FRBs), an enigmatic new class of astrophysical transient. In a 180-day survey of the Southern sky we discovered 3 FRBs at 843 MHz with the UTMOST array, as part of commissioning science during a major ongoing upgrade. The wide field of view of UTMOST ($\approx 9$ deg$^{2}$) is well suited to FRB searches. The primary beam is covered by 352 partially overlapping fan-beams, each of which is searched for FRBs in real time with pulse widths in the range 0.655 to 42 ms, and dispersion measures $\leq$2000 pc cm$^{-3}$. Detections of FRBs with the UTMOST array places a lower limit on their distances of $\approx 10^4$ km (limit of the telescope near-field) supporting the case for an astronomical origin. Repeating FRBs at UTMOST or an FRB detected simultaneously with the Parkes radio telescope and UTMOST, would allow a few arcsec localisation, thereby providing an excellent means of identifying FRB host galaxies, if present. Up to 100 hours of follow-up for each FRB has been carried out with the UTMOST, with no repeating bursts seen. From the detected position, we present 3$\sigma$ error ellipses of 15 arcsec x 8.4 deg on the sky for the point of origin for the FRBs. We estimate an all-sky FRB rate at 843 MHz above a fluence $\cal F_\mathrm{lim}$ of 11 Jy ms of $\sim 78$ events sky$^{-1}$ d$^{-1}$ at the 95 percent confidence level. The measured rate of FRBs at 843 MHz is of order two times higher than we had expected, scaling from the FRB rate at the Parkes radio telescope, assuming that FRBs have a flat spectral index and a uniform distribution in Euclidean space. We examine how this can be explained by FRBs having a steeper spectral index and/or a flatter log$N$-log$\mathcal{F}$ distribution than expected for a Euclidean Universe.Comment: 13 pages, 8 figures, 2 table

The enzymatic activity of the VEGFR2-receptor for the biosynthesis of dinucleoside polyphosphates

The group of dinucleoside polyphosphates encompasses a large number of molecules consisting of two nucleosides which are connected by a phosphate chain of variable length. While the receptors activated by dinucleoside polyphosphates as well as their degradation have been studied in detail, its biosynthesis has not been elucidated so far. Since endothelial cells released the dinucleoside polyphosphate uridine adenosine tetraphosphate (Up4A), we tested cytosolic proteins of human endothelial cells obtained from dermal vessels elicited for enzymatic activity. When incubated with ADP and UDP, these cells showed increasing concentrations of Up4A. The underlying enzyme was isolated by chromatography and the mass spectrometric analysis revealed that the enzymatic activity was caused by the vascular endothelial growth factor receptor 2 (VEGFR2). Since VEGFR2 but neither VEGFR1 nor VEGFR3 were capable to synthesise dinucleoside polyphosphates, Tyr-1175 of VEGFR2 is most likely essential for the enzymatic activity of interest. Further, VEGFR2-containing cells like HepG2, THP-1 and RAW264.7 were capable of synthesising dinucleoside polyphosphates. VEGFR2-transfected HEK 293T/17 but not native HEK 293T/17 cells synthesised dinucleoside polyphosphates in vivo too. The simultaneous biosynthesis of dinucleoside polyphosphates could amplify the response to VEGF, since dinucleoside polyphosphates induce cellular growth via P2Y purinergic receptors. Thus the biosynthesis of dinucleoside polyphosphates by VEGFR2 may enhance the proliferative response to VEGF. Given that VEGFR2 is primarily expressed in endothelial cells, the biosynthesis of dinucleoside polyphosphates is mainly located in the vascular system. Since the vasculature is also the main site of action of dinucleoside polyphosphates, activating vascular purinoceptors, blood vessels appear as an autocrine system with respect to dinucleoside polyphosphates. We conclude that VEGFR2 receptor is capable of synthesising dinucleoside polyphosphates. These mediators may modulate the effects of VEGFR2 due to their proliferative effects

The UTMOST: A hybrid digital signal processor transforms the MOST

The Molonglo Observatory Synthesis Telescope (MOST) is an 18,000 square meter radio telescope situated some 40 km from the city of Canberra, Australia. Its operating band (820-850 MHz) is now partly allocated to mobile phone communications, making radio astronomy challenging. We describe how the deployment of new digital receivers (RX boxes), Field Programmable Gate Array (FPGA) based filterbanks and server-class computers equipped with 43 GPUs (Graphics Processing Units) has transformed MOST into a versatile new instrument (the UTMOST) for studying the dynamic radio sky on millisecond timescales, ideal for work on pulsars and Fast Radio Bursts (FRBs). The filterbanks, servers and their high-speed, low-latency network form part of a hybrid solution to the observatory's signal processing requirements. The emphasis on software and commodity off-the-shelf hardware has enabled rapid deployment through the re-use of proven 'software backends' for its signal processing. The new receivers have ten times the bandwidth of the original MOST and double the sampling of the line feed, which doubles the field of view. The UTMOST can simultaneously excise interference, make maps, coherently dedisperse pulsars, and perform real-time searches of coherent fan beams for dispersed single pulses. Although system performance is still sub-optimal, a pulsar timing and FRB search programme has commenced and the first UTMOST maps have been made. The telescope operates as a robotic facility, deciding how to efficiently target pulsars and how long to stay on source, via feedback from real-time pulsar folding. The regular timing of over 300 pulsars has resulted in the discovery of 7 pulsar glitches and 3 FRBs. The UTMOST demonstrates that if sufficient signal processing can be applied to the voltage streams it is possible to perform innovative radio science in hostile radio frequency environments.Comment: 12 pages, 6 figure

The UTMOST Survey for Magnetars, Intermittent pulsars, RRATs and FRBs I: System description and overview

We describe the ongoing `Survey for Magnetars, Intermittent pulsars, Rotating radio transients and Fast radio bursts' (SMIRF), performed using the newly refurbished UTMOST telescope. SMIRF repeatedly sweeps the southern Galactic plane performing real-time periodicity and single-pulse searches, and is the first survey of its kind carried out with an interferometer. SMIRF is facilitated by a robotic scheduler which is capable of fully autonomous commensal operations. We report on the SMIRF observational parameters, the data analysis methods, the survey's sensitivities to pulsars, techniques to mitigate radio frequency interference and present some early survey results. UTMOST's wide field of view permits a full sweep of the Galactic plane to be performed every fortnight, two orders of magnitude faster than previous surveys. In the six months of operations from January to June 2018, we have performed $\sim 10$ sweeps of the Galactic plane with SMIRF. Notable blind re-detections include the magnetar PSR J1622$-$4950, the RRAT PSR J0941$-$3942 and the eclipsing pulsar PSR J1748$-$2446A. We also report the discovery of a new pulsar, PSR J1705$-$54. Our follow-up of this pulsar with the UTMOST and Parkes telescopes at an average flux limit of $\leq 20$ mJy and $\leq 0.16$ mJy respectively, categorizes this as an intermittent pulsar with a high nulling fraction of $< 0.002$Comment: Submitted to MNRAS, comments welcom

Annexin A2 mediates apical trafficking of renal Na(+)-K(+)-2Cl(-)-cotransporter

The furosemide-sensitive Na(+)-K(+)-2Cl(-)-cotransporter (NKCC2) is responsible for urine concentration, and helps maintain systemic salt homeostasis. Its activity depends on trafficking to, and insertion into, the apical membrane, as well as on phosphorylation of conserved N-terminal serine and threonine residues. Vasopressin (AVP), signaling via PKA and other kinases, activates NKCC2. Association of NKCC2 with lipid rafts facilitates its AVP-induced apical translocation and activation at the surface. Lipid raft microdomains typically serve as platforms for membrane proteins to facilitate their interactions with other proteins, but little is known about partners that interact with NKCC2. Yeast two-hybrid screening identified an interaction between NKCC2 and the cytosolic protein, annexin A2 (AnxA2). Annexins mediate lipid raft-dependent trafficking of transmembrane proteins, including the AVP-regulated water channel, aquaporin 2. Here, we demonstrate that AnxA2, which binds to phospholipids in a Ca(2+)-dependent manner and may organize microdomains, is co-distributed with NKCC2 to promote its apical translocation in response to AVP stimulation and low chloride hypotonic stress. NKCC2 and AnxA2 interact in a phosphorylation-dependent manner. Phosphomimetic AnxA2 carrying a mutant, Src-dependent phosphoacceptor (AnxA2-Y24D-GFP), enhanced surface expression and raft association of NKCC2 by 5-fold upon AVP stimulation, whereas PKC-dependent AnxA2-S26D-GFP did not. As the AnxA2 effect involved only non-phosphorylated NKCC2, it appears to affect NKCC2 trafficking. Overexpression or knockdown experiments further supported the role of AnxA2 in the apical translocation and surface expression of NKCC2. In summary, this study identifies AnxA2 as a lipid raft-associated trafficking factor for NKCC2 and provides mechanistic insight into the regulation of this essential cotransporter

Image plane detection of FRB121102 with the MeerKAT radio telescope

We present the analysis of radio interferometric 2-s images from a MeerKAT observation of the repeating fast radio burst FRB121102 on September 2019, during which 11 distinct pulses have been previously detected using high time and frequency resolution data cubes. In this work, we detected 6 out of the 11 bursts in the image plane at 1.48 GHz with a minimum peak signal-to-noise ratio (S/N) of 5 {\sigma} and a fluence detection limit of 0.512 Jy ms. These constitute the first detections of a fast radio burst (FRB) or a radio transient using 2-s timescale images with MeerKAT data. Analysis of the fitted burst properties revealed a weighted average precision of 1 arcsec in the localization of the bursts. The accurate knowledge of FRB positions is essential for identifying their host galaxy and understanding their mysterious nature which is still unresolved to this day. We also produced 2-s images at 1.09 GHz but yielded no detection which we attributed to the spectral structure of the pulses that are mostly higher in strength in the upper frequencies. We also explore a new approach to difference imaging analysis (DIA) to search for transients and find that our technique has the potential to reduce the number of candidates and could be used to automate the detection of FRBs in the image plane for future MeerKAT observations.Comment: The paper has already been accepted to MNRAS and we wait for proof of review from the publisher for final publicatio