USE OF INCOHERENT SCATTERING FOR MATRIX EFFECTS CORRECTION IN X-RAY FLUORESCENCE MEASUREMENTS OF Ti, Mn, Fe AND U CONCENTRATIONS IN URANIUM ORES

The work presents the results of method development for matrix effects correction in X-ray fluorescence measurements of Ti, Mn, Fe and U concentrations in the silicate-type uranium ore samples using wavelength dispersive XRF spectrometer S 8 Tiger (Bruker AXS GmbH, Germany). Comparison of the results obtained using standard software package Spectra Plus of the spectrometer and normalized to intensity of characteristic line of primary radiation, incoherently scattered by sample, was carried out. It is shown that for the investigated elements during X-ray fluorescent measurements of their concentrations, in addition to intensity normalization, it is necessary to use additional analytical correction. The use of this method to calculate the corrected concentrations of TiO2, MnO, Fe2O3 and U3O8 allows to decrease the relative error of measurements up to < 5 % within the range of concentrations 0.1…4 mas. % and up to ≤ 7.5 % within the range of concentrations 0.04…0.06 mas. %

Изучение биологических свойств штаммов Leptospira interrogans серогруппы Canicola в качестве кандидатных для включения в состав вакцины лептоспирозной концентрированной инактивированной жидкой для людей

Leptospirosis is a widespread zoonosis in Russia. The human leptospirosis vaccine produced by Rostov Research Institute of Microbiology and Parasitology has been used since 1998 to minimise risks associated with deterioration of epidemiological situation. Lately, there has been an increase in the incidence of leptospirosis caused by Leptospira interrogans serovar Canicola which is not included in the human vaccine. The aim of the study was to analyse biological properties of Leptospira interrogans serovar Canicola strains to substantiate their inclusion into human leptospirosis liquid concentrated inactivated vaccine. Materials and methods: two L. interrogans serovar Canicola strains: Udalov 480 and Sobaka 2000 were used in the study. Virulent properties of the strains were evaluated by infecting Syrian hamsters, the data on specific activity of the experimental vaccine were compared to specific activity of the leptospirosis liquid concentrated inactivated vaccine used for disease prevention. The experimental vaccine was tested for Specific safety and Abnormal toxicity according to FS.3.3.1.0014.15 Leptospirosis liquid concentrated inactivated vaccine. Results: the comparison of Udalov 480 and Sobaka 2000 strains of L. interrogans serovar Canicola revealed higher virulence of Udalov 480. The tests performed for the experimental vaccine batches demonstrated that the inclusion of Udalov 480 strain did not affect the above-mentioned properties of the vaccine. Conclusions: the study demonstrated the possibility of using L. interrogans serovar Canicola strain Udalov 480 as a component of the currently produced vaccine, and confirmed the safety and efficacy of the new vaccine.Лептоспироз является одним из широко распространенных зоонозных заболеваний в России. Для снижения рисков, связанных с осложнением эпидемиологической обстановки, применяется лептоспирозная вакцина для человека, производимая с 1998 г. ФБУН РостовНИИМП Роспотребнадзора. В настоящее время увеличилась заболеваемость людей лептоспирозом, вызванным Leptospira interrogans серогруппы Canicola, отсутствующим в составе производимой лептоспирозной вакцины для людей. Цель работы: изучить биологические свойства штаммов Leptospira interrogans серогруппы Canicola для обоснования их включения в вакцину лептоспирозную концентрированную инактивированную жидкую для людей. Материалы и методы: в исследовании были использованы два штамма лептоспир серовара Canicola: № 480 Удалов и Собака 2000. Оценку вирулентных свойств штамма проводили путем инфицирования золотистых хомячков. Данные, полученные для серий экспериментальной вакцины по показателю «Специфическая активность», сравнивали с соответствующими данными серий вакцины лептоспирозной концентрированной инактивированной жидкой, применяемой для профилактики заболевания. Экспериментальную вакцину испытывали по показателям «Специфическая безопасность» и «Аномальная токсичность» согласно ФС 3.3.1.0014.15 Вакцина лептоспирозная концентрированная инактивированная жидкая. Результаты: при проведении сравнения вирулентности двух штаммов лептоспир серовара Canicola № 480 Удалов и Собака 2000 было выявлено, что более высокой вирулентностью обладает L. interrogans Canicola штамм № 480 Удалов. Испытания полученных серий экспериментальной вакцины показали, что включение в нее вышеуказанного штамма не приводит к изменению изученных свойств вакцины. Выводы: подтверждена возможность введения в состав производимой вакцины штамма № 480 Удалов L. interrogans Canicola, а также ее эффективность и безопасность

Study of biological properties of <I>Leptospira interrogans</I> serovar <I>Canicola</I> strains as candidate components of human leptospirosis concentrated inactivated vaccine

Leptospirosis is a widespread zoonosis in Russia. The human leptospirosis vaccine produced by Rostov Research Institute of Microbiology and Parasitology has been used since 1998 to minimise risks associated with deterioration of epidemiological situation. Lately, there has been an increase in the incidence of leptospirosis caused by Leptospira interrogans serovar Canicola which is not included in the human vaccine. The aim of the study was to analyse biological properties of Leptospira interrogans serovar Canicola strains to substantiate their inclusion into human leptospirosis liquid concentrated inactivated vaccine. Materials and methods: two L. interrogans serovar Canicola strains: Udalov 480 and Sobaka 2000 were used in the study. Virulent properties of the strains were evaluated by infecting Syrian hamsters, the data on specific activity of the experimental vaccine were compared to specific activity of the leptospirosis liquid concentrated inactivated vaccine used for disease prevention. The experimental vaccine was tested for Specific safety and Abnormal toxicity according to FS.3.3.1.0014.15 Leptospirosis liquid concentrated inactivated vaccine. Results: the comparison of Udalov 480 and Sobaka 2000 strains of L. interrogans serovar Canicola revealed higher virulence of Udalov 480. The tests performed for the experimental vaccine batches demonstrated that the inclusion of Udalov 480 strain did not affect the above-mentioned properties of the vaccine. Conclusions: the study demonstrated the possibility of using L. interrogans serovar Canicola strain Udalov 480 as a component of the currently produced vaccine, and confirmed the safety and efficacy of the new vaccine

Development and examination of radiation-resistant austenitic chromium-nickel steels alloyed with scandium

Translated from Russian (Paper presented at the National NDT Conference, Kiev, 1996)SIGLEAvailable from British Library Document Supply Centre-DSC:9023.190(VR-Trans--8236)T / BLDSC - British Library Document Supply CentreGBUnited Kingdo