Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections

This review article analyzes the data on the role of selenium in the regulation of the metabolic and immune status of a macroorganism. The data on endogenousfunctional selenium-containing molecules, which include selenocysteine, selenomethionine, and selenoproteins, are considered. The data on the pathologies associated with the deficiency of this microelement, its  immunotropic properties and adjuvant effects are presented. The role of selenoproteins in the regulation of redox processes has been shown. The data on the immunotropic activity of compounds containing selenium and the prospects for their use as adjuvants are analyzed. The last section is devoted to the analysis of literature data on the biological properties of synthetic selenium compounds with an activity that mimics the catalytic activity of selenoproteins. The analysis of the data on the functional activity of selenoproteins carried out in this work indicates their key role in the regulation of metabolic and immune processes, as well as in maintaining homeostasis. The information presented in this review on the biological activity and mechanisms of action of new synthetic low-toxic organic compounds of selenium can serve as a basis for the development of nonspecific means of metabolic and immune correction of vaccinal processes caused by both live attenuated vaccines and artificially created ones

FEATURES OF EMOTIONALLY-PERSONAL SPHERE IN PATIENTS WITH SHARP DECREASE OF VISUAL FUNCTIONS

The aim of the work was to reveal features of emotionally-personal sphere in patients with sharp decrease of visual functions. We studied emotionally-personal features of 37 patients. The main group included 18 patients with sharp decrement in visual acuity down to 0,001 in consequence of the retinal detachment, hemophthalmia and eye thrombosis at 1-2 months term before the examination. Control group included 19 patients without eye pathology. Obtained results show that patients with sharp decrease of visual functions have emotionally-personal features that influence their quality of life

Features of emotional and personality status of patients with central serous chorioretinopathy

The features of emotional and personality status of patients with central serous chorioretinopathy are analyzed in this article. The study of emotional and personality features of 27 people from 27 to 62 years (average age - 47,7 ± 8,5years) which were in treatment with a sharp decrease in visual acuity from 0,8 to 0,05 as a result of developed central serous chorioretinopathy. It was found that patients with central serous chorioretinopathy in 50 % of cases are characterized by: 1) the severity of psychopathologic symptomatology; 2) super-strong and sometimes obsessive attitude to work, as well as an understatement of "significance" of the disease in favor of maintaining the working status; 3) the desire to overcome difficulties due to targeted analysis of stressful situations; 4) stable tendency to perceive a large range of situations as threatening the well-being; 5) the deterioration of the quality of life, which is characterized by dissatisfaction with the state of health (especially in visual acuity). Thus, these results show that patients with central serous chorioretinopathy have emotional and personality features aggravating the overall condition of the patient

Individual and personal qualities of bailiffs with various types of professional deformation

Background. Insufficient knowledge of the professional deformation of bailiffs with the accumulated research material that reveals the essence of this phenomenon, as well as the need to take into account the specifics of the activity and individual and personal characteristics of this category of employees, determine the relevance of this study.The aim: to identify and describe the individual and personal qualities of bailiffs with various professional deformation types.Material and methods. In this work, the following research methods were used: the author’s questionnaire for assessing seven types of professional personal deformation; psychological testing of individual and personal qualities using methods regulated by departmental documents; statistical methods (descriptive statistics, two-stage cluster and correlation analyzes). The study involved 277 employees of the Federal Bailiff Service of the Arkhangelsk region.Results. Bailiffs showed such professional deformations as overcontrol, authoritarianism and conservatism. The interrelation of all professional deformation types severity with the individual and personal qualities of the bailiffs, which are among the professionally important qualities, has been established. At the same time, the insufficient expression of these qualities contributes to the professional deformation development. The only exceptions are the level of active communication and normativity, which, with excessive development, also contribute to the appearance of personality deformations and contribute to a decrease in the effectiveness of activities. Most types of character accentuations and their various combinations contribute to the professional deformation development of bailiffs, i. e., are her personality markers. Moderate severity of the dysthymic type of character accentuation reduces the likelihood of developing occupational deformity.Conclusion. Within the framework of the practical use of the results of this study, it is necessary, when conducting professional selection of personnel and periodic assessment of personnel, to pay attention to the level of expression of professionally important qualities that have a relationship with key types of professional deformation. This will allow timely implementation of measures to prevent the development of professional deformations of employees

MODERN APPROACHES TO THE ASSESSMENT OF THE COMPLIANCE OF OPHTHALMOLOGICAL SERVICE OF IRKUTSK REGION TO THE REQUIREMENTS FOR MEDICAL TREATMENT PROCEDURE

The purpose of study was to analyze the compliance of medical organizations providing primary ophthalmological care to the population to the requirements of the Federal Law N 323-Fz in maintenance of procedure of medical treatment. The article presents the results of the development and implementation of organizational approaches to the assessment of compliance of ophthalmologic service of Irkutsk region to the requirements for medical treatment procedure. The informational possibilities of offered technologies in adequacy of development of measures for improvement of the functioning of ophthalmic services are showed

INFLUENCE OF THE MEDICAL OZONE ON INTENSITY OF PHENOL MIGRATION FROM PVC MEDICAL INFUSION SET INTO WATER SOLUTION

In article the results of investigating the phenol migration from polyvinyl chloride medical infusion set into contacting water solution were presented. The perfusion of ozonized, physiologic solutions through the medical infusion set extended, in clinical practice can be accompanied, by migration of phenol from a polymeric material with concentration up to 1 mg/l

Changes in the Organs of Experimental Animals in the Dynamics of the Infectious Process Caused by <i>Bacillus Anthracis</i> with Different Plasmid Profiles

Background. The current direction is the study of anatomical and histological changes caused by the causative agent of anthrax with a different plasmid profile. It was found that Bacillus anthracis strains with the same set of plasmids and the same morphological, serological and cultural properties sometimes have different pathogenicity.Aim of the study. Comparative analysis of anatomical and histological changes in the organs of experimental animals in the dynamics of the infectious process caused by the pathogen B. anthracis with different genotypes.Methods. Four strains were used as the study object: B. anthracis I-275 (pCO1–/ pCO2–), B. anthracis I-323 (pCO1–/ pCO2–), B. anthracis I-217 (pCO1+/pCO2– and B. anthracis 34F Stern pCO1+/pCO2–). The study was conducted on 260 certified white mice. Histological material was embedded in paraffin, semi-thin sections were stained with hematoxylin-eosin, thionine, and according to Brachet. The severity of pathological changes, the presence of the pathogen, and the proliferation of plasma cells were evaluated. The changes detected during the autopsy of the animal and the results obtained during the histological examination of the anatomical material were analyzed and generalized. Microphotography and quantitative analysis of plasma cells were performed using the “Motic Images Plus 2.0” application software package. Statistical processing of the obtained data was performed using the computer program “Statistics”, version 6 (Novosibirsk). The results were considered reliable if the probability of error was less than 0.05 (p &lt; 0.05) in relation to the control.Results. Differences in anatomical and histological changes in organs and tissues of white mice infected with B. anthracis with the same set of plasmids were revealed. It was found that in animals infected with non-plasmid strains of B. anthracis, the proliferation of plasma cells is significantly reduced compared to animals infected with singleplasmid strains of the anthrax pathogen.Conclusion. The obtained data suggest that the revealed differences are related to the plasmid profile of the studied strains, but also to the peculiarities of their enzymatic activity, adhesion ability, and other factors. Thus, anthrax strains that have the same morphological, serological and cultural properties sometimes have different virulence. And also, anthrax strains that have lost virulence lose their immunogenicity, as evidenced by the ratio of plasma cells

Structural rearrangement of organs of white mice vaccinated with Yersinia pestis EV in combination with organoselenium compound 974zh

Introduction. An urgent direction is the search for means that increase the effectiveness of the Y. pestis EV NIIEG vaccine and reduce the side pathological manifestations caused by it. Organoselenium compounds have immunotropic properties and increase the antioxidant potential of the body, as well as have an antidystrophic effect and an antiallergic effect. Materials of the study of the immunomodulating effect of the experimental selenium-containing compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the macroorganism of laboratory animals are presented.The aim. To evaluate the effect of the organoselenium compound 974zh on the structural rearrangement of the organs of experimental animals in the dynamics of the vaccine process caused by Y. pestis EV.Methods. The study was carried out on 70 certified outbred white mice. Histological material (thymus, lymph nodes, spleen, adrenal glands, liver) was embedded in paraffin, semi-thin sections were stained with hematoxylin and eosin, thionin, and by the Brachet method. The severity of pathological changes in the liver and adrenal glands, proliferation of plasma cells and structural changes in immunocompetent organs (thymus, lymph nodes and spleen) were assessed. Microphotography and quantitative analysis were performed using MoticImagesPlus 2.0. Statistical processing was carried out using the computer program Statistica.Results. It has been established that the combined administration of 974zh and Y. pestis EV leads to morphological and functional restructuring of immunocompetent organs, enhances the proliferation of plasma cells in the spleen and lymph nodes, and eliminates negative changes in the liver and adrenal glands. Conclusion. Thus, the 974zh preparation enhances the immunogenic effect of the Y. pestis EV vaccine strain, increasing the T- and B-dependent zones of the spleen and lymph nodes, increasing the proliferation of plasma cells, and also significantly reduces pathological changes in the liver and adrenal glands

Characteristics of mukoviscisidosis in the southern regions of Russia

Introduction. Cystic fibrosis (CF) is a  hereditary disease with genetic heterogeneity and clinical polymorphism. Expanding the range of knowledge about the characteristics of the course of the disease in different regions is important to achieve the goal of improving the quality and life expectancy.Purpose. Comparative analysis of the features of the course of CF in the subjects of the Southern Federal District, Stavropol Territory.Methods. Data from the National Register of Patients of the RF MV 2016 were used. Results: there are clinical and genetic features between the regions of the Southern Federal District and the Stavropol Territory of the North Caucasus Federal District and in general with the Russian Federation. Analysis of the data showed differences in indicators: the proportion of patients aged ≥ 18 is the lowest in the Republic of Crimea (14.9%), in the Rostov region the lowest average age of patients (9.0 ± 6.3), and the lowest age of diagnosis 2.2 ± 3.1 years. Late terms of diagnosis were revealed in the Stavropol Territory (4.0 ± 8.0 years), but here there is one of the highest average age of CF patients (14.1 ± 11.5), the proportion of adult patients (23.3%) and the lowest allelic frequency of F508del, which is determined by the high number of patients with a “soft” genotype. There is a high proportion of patients with an undetermined genotype. A low proportion of two identified genetic variants of the CFTR gene is registered in patients of the Republic of Crimea. A low frequency of Burkholderia cepacia complex and Achromobacter spp was revealed, and a high infection with non-tuberculous mycobacteria was revealed in the Rostov region. FEV1 in children and adults was lower in Rostov Region and Stavropol Territory. In all regions, there is a discrepancy between the seeding of flora and azithromycin therapy and the severity of the genotype with the use of pancreatic enzymes.Conclusions. Analysis of the data of the registry, which allows substantiating the need to study the regional characteristics of the course of CF in order to differentiate the planning of measures to improve the quality of medical care for patients with CF