Налоговое или монетарное стимулирование? Эволюционные аргументы в пользу налоговых реформ

Статья посвящена исследованию проблемы обоснования мер регулирования развития эмерджентной экономики - фискальных и (или) монетарных, с использованием методов эволюционного моделирования. Для этого была построена экономико-математическая модель, имитирующая процессы коэволюции развитой и развивающейся стран, связанных через глобальные цепочки создания стоимости. В этой модели каждая из стран характеризуется собственной исходной структурой экономических субъектов, определяемой соотношением предприятий-эгоистов (предрасположенных к консервативному поведению) и предприятий-альтруистов (предрасположенных к инновационному поведению), а также специфическим населением и демографическими процессами. Результаты вычислительных экспериментов показали, что успех того или иного способа экономического регулирования принципиально зависит от особенностей исходного состояния институциональной среды хозяйствования. В институциональной среде с «прозрачными» длинными правилами игры и, соответственно, длинным горизонтом хозяйственного планирования наилучший результат в виде высоких темпов роста производства в эмерджентной экономике дает политика дешевых денег в сочетании с высокими «европейскими» налогами. Иная ситуация наблюдается в более реалистичной ситуации с короткими правилами игры и, соответственно, коротким (не более 5 лет) горизонтом хозяйственного планирования. В этом случае любая налоговая политика (низкие или высокие налоги) в сочетании любыми деньгами (дешевыми или дорогими), в определенном смысле теряет значение, поскольку изначально отсталая инновационная система не позволяет быстро получать высокие результаты, а преимущества экономического роста в отделенном будущем не принимаются во внимание. Вместе с тем, для постепенного формирования лучшей инновационной системы низкие налоги и дешевые деньги имеют важное значение, поскольку создают лучшие условия для выживания предприятийальтруистов, облегчая им инвестиционную деятельность, способную принести многократный прирост технической производительности и экономической эффективности. В любом случае, в контексте эволюционной экономической теории, исходя из проведенных вычислительных экспериментов, налоговая политика в условиях эмерджентных рынков сохраняет свой регуляторный потенциал, и, таким образом, требует дальнейшего реформирования в контексте «новой реальности», основанной на глобальных цепочках создания стоимости.The article deals with the problem of substantiation of the emergent economies development regulatory measures (fiscal and / or monetary), using the evolutionary modelling methods. For this purpose, the mathematical model was constructed that simulates the co-evolution process of the advanced and developing countries, linked by global value chains. In this model, each country is characterized by its original structure of economic entities, defined by the ratio of the egoistic enterprises (predisposed to conservative behaviour) to the altruistic enterprises (predisposed to innovation), as well as by specific population and demographic processes. The results of the computational experiments have shown that the success of economic regulation fundamentally depends on the peculiarities of the initial state of the institutional environment. In the institutional environment with the «transparent» long behaviour and, accordingly, a long economic planning horizon, the best result in the form of average annual production growth rate of the emergent economies is provided by the cheap money policy combined with the high European taxes. A different situation is observed in more realistic short behaviour and, accordingly, short (under 5 years) economic planning horizon. In this case, any tax policy (neither low nor high taxes) together with any money (neither cheap nor expensive), to a certain extent loses its significance, as the initially backward innovative system does not allow to quickly get good results, and the long-term benefits of the potential economic growth are not taken into consideration. However, low taxes and cheap money are important as they create better conditions for survival of the altruistic enterprises, facilitating their investment activities, which can multiply increase their technical performance and economic efficiency. Still, in the context of the evolutionary economics and following the conducted computational experiments, the fiscal policy in terms of emerging markets retains its regulatory capacity, and therefore requires further reforms in the context of the «new reality» based on the global value chains

ARGO: a web system for the detection of degenerate motifs and large-scale recognition of eukaryotic promoters

Reliable recognition of the promoters in eukaryotic genomes remains an open issue. This is largely owing to the poor understanding of the features of the structural–functional organization of the eukaryotic promoters essential for their function and recognition. However, it was demonstrated that detection of ensembles of regulatory signals characteristic of specific promoter groups increases the accuracy of promoter recognition and prediction of specific expression features of the queried genes. The ARGO_Motifs package was developed for the detection of sets of region-specific degenerate oligonucleotide motifs in the regulatory regions of the eukaryotic genes. The ARGO_Viewer package was developed for the recognition of tissue-specific gene promoters based on the presence and distribution of oligonucleotide motifs obtained by the ARGO_Motifs program. Analysis and recognition of tissue-specific promoters in five gene samples demonstrated high quality of promoter recognition. The public version of the ARGO system is available at and

Coherent interactions between phonons and exciton or exciton-polariton condensates

We analyse the interaction of exciton and exciton-polariton condensates in semiconductor microcavity with a coherent acoustic wave. An analytical solution for the dispersion of excitations of coupled condensate-phonon system is found in the approximation of k-independent interactions. Accounting for k-dependence results in a stronger modification of the dispersion, and even in the appearance of the "roton instability" region

The use of graphics accelerators to detect functional signals in the regulatory regions of prokaryotic genes

Various methods for identification of significant contextual signals are widely used to search for transcription factor binding sites and to identify the structural and functional organization of regulatory regions. These methods do not require any pre-alignment of the sample sequences analyzed or experimental information about the exact location of transcription factor binding sites. Methods of searching for contextual signals, based on the identification of degenerate oligonucleotide motives recorded in the 15-letter IUPAC code have become widespread. An essential problem with degenerate motifs is their great diversity, which makes the researchers apply heuristics which do not guarantee that the most significant signal will be found. The development of high-performance computing systems based on the use of graphics cards has made it possible to use the exact exhaustive methods to identify significant motifs. We have developed a new system for identifying significant degenerate oligonucleotide motifs of a given length in the regulatory regions based on the use of widespread graphics cards that provides a search for the signal with the greatest significance. High efficiency of the GPU compared with CPU was demonstrated. Using the proposed approach, we analyzed the regulatory regions of B. subtilis, E. coli, H. pylori, M. gallisepticum, M. genitalium and M. pneumoniae genes. Sets of degenerate motifs have been identified for each species of prokaryotes. They were classified on the basis of similarity with the transcription factor binding sites of E. coli

Multistability of cavity exciton-polaritons affected by the thermally generated exciton reservoir

Until now, the generation of an excitonic reservoir in a cavity polariton system under quasi-resonant pumping has always been neglected. We show that in microcavities having a small Rabi splitting (typically GaAs cavities with a single quantum well), this reservoir can be efficiently populated by polariton-phonon scattering. We consider the influence of the exciton reservoir on the energy shifts of the resonantly pumped polariton modes. We show that the presence of this reservoir effectively reduces the spin anisotropy of the polariton-polariton interaction, in agreement with recent experimental measurements, where the multistability of cavity polaritons has been analyzedComment: 7 pages, 6 figure

Surgical Treatment of Giant Cavernous Hemangioma Liver

In the past five years, 16 adults (10 females, age 25–61 years, mean 48) with giant cavernous hemangioma of the liver measuring 15–31 cm (mean-19) underwent surgery in a single Institution. Diagnosis was made with the help of multimodal investigations– ultrasound (US), computed tomography (CT), hepatic angiography, hepatic scintigraphy and fine needle biopsy. Ultrasound and CT had sensitivities of 69% and 82% respectively. Fourteen had preoperative selective hepatic artery embolization to study its effect on operative blood loss. Indication for surgery in all cases was a large abdominal mass with varying severity of pain. In addition, 5 had hemetological and/or coagulation abnormalities, hemobilia in and pyrexia in 1. Seven left lobectomies, 3 left lateral segmentectomies, 2 right lobectomies, 2 right trisegmentectomies and 4 non-anatomical resections of to 3 segments were performed. Postoperative complications developed in 25% with no operative mortality. Preoperative selective hepatic artery embolization helped to decrease the operative hemorrhage in 13 (mean blood loss– 1146 ml). In two cases severe bleeding required use of Cell-saver and massive donor blood transfusion. Our results suggest use of preoperative selective hepatic artery embolization and Cell-saver as an adjunct to the liver resection for these vascular tumors