Actuality IT - consulting in conditions of the Russian economy

The purpose of it consulting is to provide recommendations on the strategic management of information systems, evaluation, design and development of it architecture, project management, automation of business processes of organizations, and many other issues related to using of computers and information technology. This paper describes typical tasks of consulting projects in the it sector, the structure of the Russian market of it services-consulting, action for development and regulation of the market of it-consulting in conditions of the Russian economyНазначение ИТ - консалтинга заключается в предоставлении рекомендаций по вопросам стратегического управления информационными системами, оценки, проектирования и разработки ИТ - архитектуры, управления проектами автоматизации бизнес-процессов организаций и многим другим вопросам, связанным с использованием вычислительной техники и информационных технологий. В данной работе описаны типовые задачи консалтинговых проектов в сфере ИТ, определена структура российского рынка услуг ИТ - консалтинга, меры по развитию и регулированию рынка ИТ - консалтинга в условиях российской экономик

ОЦІНКА РЕЗУЛЬТАТІВ НАУКОВОЇ ДІЯЛЬНОСТІ В КЛАСИЧНИХ УНІВЕРСИТЕТАХ ПІДПРИЄМНИЦЬКОГО ТИПУ В УМОВАХ ЄВРОІНТЕГРАЦІЇ

The urgency of the research is driven by the need to select and apply such scientometric tools to estimate scientific and academic productivity of scholars from classical universities that are relevant to current economic environment in Ukraine and the entrepreneurial university model. The main approach to this research is based on systemic analysis of the modern scientific thought condition against estimation of scholars productivity; comparative analysis of scientometric Scopus, Web of Science and Google Scholar bases; determination of efficiency from applying commercial and free scientometric bases under entrepreneurial university model. This article aims at detecting an opportunity and viability of applying Google Scholar free scientometric base to estimate scholars productivity at classical universities in the context of Ukrainian environment. Based on the research results obtained, the hypothesis on association between h-index in Scopus and Google Scholar values for scholars of STEM and natural disciplines from classical universities has been proved. In addition, this article provides theoretical facts that evidence another hypothesis on an opportunity to design the so called h-index in ProxyScopus for scholars of socio-economic and humanitarian disciplines from classical universities. This approach allows improving efficiency of budget allocation for universities as well as productivity of the scholars, but also meets principles of entrepreneurial university framework. The article materials can be of great interest for management of classical universities, state education agencies on education and science as well as scholars and experts in the field of management of entrepreneurial universities

The use of 3D technology-printing in the formation of students' information literacy

The article explains how to use the new 3D printing technologies in educational institutions, such as the Institute and school, is an example of using this method for the course of computer graphicsВ статье описана методика использования новой современной технологии 3D-печати в учебных заведениях, таких как институт и школа, приводится пример использования данной методики при изучении курса компьютерной график

Presentations in Lectures to Prompt Innovations in Higher Education

Considering the rich experience of using multimedia presentations as a teaching tool in higher education, in order to introduce new approaches and develop a methodology, there is a need to identify the strengths and weaknesses of existing practices, in particular to identify the emotional attitude of university students to existing lectures and presentations in the educational process and determine relevant opportunities to improve the practice of using interactive and visual educational tools.The empirical basis of the study was the results of a survey of students of 2–4 undergraduate courses at the Moscow State Institute of International Relations (University) of the Russian Ministry of Foreign Affairs in the 2019–2020 academic year. The survey involved 404 respondents. To process the obtained data, we used the Google Forms and Microsoft Office Excel programs, general scientific methods (comparison, generalization), statistical analysis methods, as well as content analysis.The empirical study showed a high level of student satisfaction with the volume and effectiveness of multimedia presentations used in the educational process, and also confirmed the theoretical ideas about the advantages and limitations of linear form presentations that dominate in the educational environment. Critical remarks included design errors, oversaturation of visual material, activity out of sync, and flaws in speaker behavior. Among the new techniques for working with presentation materials, photographing slides was noted. An important observation was the students’ request for self-sufficient visual materials of lectures and access to them.Prospects and opportunities for transforming familiar lectures and the learning environment as a whole were identified taking into account the existing experience of presentations at the university; ways of solving the problems with students’ perception and acquisition of material are proposed and specific recommendations are given for organizing a wide range of classes with visual and interactive components, today these are, first of all, remote online courses (MOOC, e-learning) and new forms of organization classroom activities (“flipped classroom”)

Efficacy and safety of various brimonidine formulations in the treatment of glaucoma and ocular hypertension

Purpose. To present data on the mechanism of action, efficacy, and side effects of various brimonidine dosage forms in the treatment of glaucoma and ocular hypertension.Material and methods. To perform the review, literature sources were searched through the PubMed and Scopus databases up to and including 2021, using the keywords «brimonidine», «efficacy», «safety», «glaucoma medication». A total of 36 articles related to the topic of the review were selected. The beginning of publications on this topic dates back to 1995.Results. Brimonidine, an alpha2-adrenoceptor agonist, effectively reduces intraocular pressure and can be used as monotherapy, adjuvant and replacement therapy. The effectiveness of brimonidine is similar to that of timolol and prevails over betaxolol but inferior to prostaglandin analogues. The new drug formulation brimonidine-purite 0.15% has a more favorable safety and tolerability profile than the original brimonidine 0.2% while maintaining similar efficacy. However, most patients require two or more hypotensive medications to maintain target IOP. In this context, brimonidine is one of the most appropriate drugs because of its pr oven efficacy when combined with other classes of hypotensive drugs.Conclusion. Brimonidine can be used as monotherapy for glaucoma and ophthalmic hypertension. Experimental and clinical studies have shown a potential neuroprotective effect of brimonidine, which is associated with a direct effect on retinal cells, regardless of the effect of the drug on intraocular pressure

Efficacy of metformin for treatment and prevention of antipsychotic-induced overweight and obesity in women: an open-label, randomized, prospective placebo-controlled study

Background: The prevalence of obesity and metabolic abnormalities is increased patients with mental disorders receiving psychopharmacotherapy, which significantly impairs their treatment adherence.Aims: To evaluate the efficacy and safety of metformin in prevention and treatment obesity and overweight in patients with mental disorders receiving antipsychotics.Materials and methods: This was an open-label, prospective, randomized, placebo-controlled study of female patients with mental disorders (age, 18 to 50). The patients were randomized into two groups in a 2:1 ratio: the treatment group received metformin and the control group received placebo. Metformin was administered at a starting dose of 500 mg daily, with subsequent up-titration every 2 weeks when necessary, up to 2000 mg daily. The treatment duration was 6 months.Results: Baseline BMI in the treatment group (N=62) was 27,3 [24,0; 30,4] kg/m2; it decreased to 26,0 [22,5; 30,5] kg/m2, p < 0.0001, Wilсoxon test) after 6 months of treatment. The patients receiving metformin decreased their body weight by 3 [-6; 0] kg, or  -4,0 [-8; 0] %. In the placebo group (N=30), the baseline BMI was 27,5 [24,0; 32,0] kg/m2 and increased to 28,2 [25,8; 34,0] kg/m2 at 6 month (p=0.001, Wilсoxon test), or 3 [1; 6] kg. After 6 months of treatment, the difference in BMI between the metformin and placebo groups was significant (26,0 и 28,2 kg/m2, respectively, р=0,027, Mann-Withney test). Six (6) of 62 patients treated with metformin had side effects and were switched to an equivalent dose of prolonged release metformin, with reduction of side effects in 5 of them.Conclusions: The use of metformin in patients with mental disorders receiving antipsychotics allows for reduction or stabilization of body weight in 80% of cases, with ≥5% decrease of body weight in 44% of patients. It is recommended to start metformin at a dose of 500 mg daily with subsequent up-titration of up to 2000 mg if necessary

Formation of the recombinant adenovirus encoding codon-optimized dysferlin gene and analysis of the recombinant protein expression in cell culture in vitro

Dysferlinopathies belong to neuromuscular diseases associated with aberrant expression and/or function of dysferlin protein in skeletal muscle, which is caused by mutations in the dysf (dystrophy-associated fer-1-like, DYSF) gene. Because of the large size of the codon-optimized dysf coding region (6243 bp), adenoviral vectors are suitable for the creation of genetic constructs, which are capable of delivering a large amount of recombinant genetic information into both dividing and non-dividing cells, as well as provide a high level of transgene expression. We generated a recombinant adenovirus serotype 5 encoding a codon-optimized gene for human dysferlin (Ad5-Dysf) and analysed recombinant protein expression in vitro in HEK-293T cell line

Analysis of Bj fibroblasts mitochondrial respiratory chain function under glucose starvation and exposure to different doses of rotenone: Implications for neurogenerative diseases

Certain neurodegenerative diseases, such as Parkinson and Alzheimer, are characterizing by an impairment in mitochondrial function and biogenesis, which may lead to pathological changes in the central nervous system. From this putative link stems a growing interest in changes to the mitochondrial electron transport chain and the ensuing energy dysfunction in neuronal cells and connective tissue cells under normal and pathological conditions. Fibroblasts involved in the formation of microenvironments of different types of specialized cells from the nervous system and their dysfunction may contribute to the pathogenesis of disease as well. In this regard, we have obtained stressful conditions of human dermal fibroblasts approximating of the pathological phenotype observed in Parkinson's disease. Was studied the expression and activity of the protein complexes of the mitochondria respiratory chain including translocase TOM20 under inhibition of NADH dehydrogenase and maintaining of oxidative stress

Modeling and gene therapy of dysferlinopathy

Dysferlinopathies is a group of autosomal-recessive inherited neuromuscular diseases, which are characterized by defect in mRNA expression or in functionioning of dysferlin protein, appearing in about 1/200 000 births. Dysferlin is encoded by DYSF gene (Dystrophy-associated fer-1- like). It's disruption can cause various types of primary dysferlinopathies, which include Miyoshi myopathy (MM), Limb-girdle Muscular Dystrophy type 2B (LGMD2B) and distal myopathy with anterior tibial onset. Also, dysferlin deficiency can be associated with other diseases, such as caveolin- And calpainopathies. Here we discuss dysferlin protein structure and function, it's clinical phenotypes, known animal models and developing treatment strategies for dysferlinopathies. © Human stem cells institute, 2013