Main factors of primary arterial hypertension development and pathogenesis in young, call-up-aged men with complicated family anamnesis

To identify the role of cardiovascular pathology, renal, renovascular and renourinal anomalies, neurogenic and endocrine diseases in arterial hypertension (AH) pathogenesis among young, call-up-aged men hospitalized for examination and primary AH diagnosis verification, 60 men aged 16-26 years were included in the study. Hemodynamics was assessed by blood pressure (BP) office measurement and ambulatory monitoring, together with B-mode echocardiography data. Renal and renourinal structure and function was assessed by static and dynamic scintigraphy, renal ultrasound, renal radiography, excretory urography, color Doppler angiography of renal arteries, measurement of microalbuminuria in morning urine and glomerular filtration rate by endogenous creatinine. Plasma levels of uric acid, red blood cell ABO antigens, and Rhesus factor were also assessed to verify familial AH predisposition. AH was not an isolated pathology, being combined with various anomalies and disorders of kidneys, renal vessels, renourinary, cardiovascular, endocrine systems, as well as with metabolic disturbances and obesity. In more than 50% of the cases, renal anomalies were explained by genetic or intrauterine factors. The results obtained point to the importance of genetic and inherited renal anomalies' role in chronic AH syndrome development among young, call-up-aged men

Stratigraphy and paleolithic landscapes of the Beganchik site at the Kama-Volga confluence

The Beganchik locality is a stratigraphic sequence of loessic deposits, pedogenic horizons and Paleolithic occupations located at the Kama-Volga confluence. The sequence is exposed on a bluff formed on the west side of an erosional remnant between the Kuybyshev Reservoir and the former channel of the Aktay River. Although the site is known for its Terminal Paleolithic-Mesolithic occupations of the Pleistocene-Holocene transition, evidence of older occupations and remains of fauna has been identified. Our research team identified evidence of human presence associated with a pedogenic horizon of MIS 3 age. Two AMS radiocarbon ages from a hearth produced ages around 47 000 years BP. Pollen and phytoliths from two soils horizons, including the one associated with the hearths indicate a steppe environment coincident with the formation of correlative soils elsewhere in the Russian Plain

Modern data concerning to clinic and pathogeneD sis of severe and malignant arterial hypertension

Tо determine principal pathogenetic factors of therapy-resistant arterial hypertension (AH), 41 patients were examined: 1 male and 40 females aged 34-65 years, who suffered from malignant arterial hypertension (MAG). Control groups included 43patients (2 males and 341 females, aged 25-66 years) with Stage I-II AH by WHO-ISH classification (1999), as well as Stage III AH patients (N=45, 2 males and 43 females, aged 34-65 years). Intracardiac and central hemodynamics was assessed by echocardiography, renal function - by renoradiography, dynamic and static renoscintigraphy, and endogenous creatinine clearance. 24-hour extraction of cyclic nucleotides (cAMP and cGMP) was assessed by radioimmune method. Renal parenchimal disorders and vasorenal factors were the leading factors of MAH development. In MAH pathogenesis, various pathogenic factors - renal, vascular, endocrine, metabolic, and neurologic - were combined. All MAH patients demonstrated resistant hemodynamic type, with severe vasospastic reactions of eye vessels, and increased cGMP excretion, a symptom of reduced vasodilatator (NO) synthesis in vascular endothelium

Visualization 1: Digital holographic microscopy in label-free analysis of cultured cells’ response to photodynamic treatment

Visualization 1 presents the alteration dynamics in HeLa cells induced by 7-min irradiation and recorded in both optical and holographic microscopes. Originally published in Optics Letters on 01 November 2016 (ol-41-21-5035