Greater Eurasia Project in the Context of Interdisciplinary Discourse

The article defines the basic methodological principles of the project “greater Eurasia”, involving the solution of the complex problems of the promotion of global security and sustainable world order in the “era of geopolitical tension” associated with the onset of “Globalization 2.0” at the initial stage of the sixth technological order, a revolutionary transition from “analog” to “digital era” at the beginning of the XXI century and the rethinking of anthropological values caused by the inclusion of the everyday life of modern human artificial intelligence — in the guise of an assistant, a controller of human behavior and actions, or a Chapek robot

Selection of options for the reconstruction of the power supply system based on the fuzzy sets theory and the crit eria of decision-making theory

The article proposes a method for selecting options for the reconstruction of the power  supply  system  based  on  the  criteria  of  decision-making  theory.  The  reconstruction process  is  considered  as  a  sequential  game  with  two  players :  active  and  passive.  The probability of possible states of the system is determined on the basis of the fuzzy sets theory. The main criterion for the choice of the reconstruction option is the value of damage from the power  supply  interruption.  The  application  of  the  proposed  method  is  considered  on  the example of a large metallurgical enterprise

ANALYSIS OF CLINICAL CASES АНТИ-VEGF TREATMENT OF MASSIVE SUBRETINAL HEMORRHAGES COMPLICATING WET AGE-RELATED MACULAR DEGENERATION

Purpose. Analysis of clinical cases of anti-VEGF therapy (ranibizumab) in the treatment of wet age-related macular degeneration (AMD) complicated by massive subretinal hemorrhages of various sizes.Material and methods. A retrospective analysis of the results of treatment was performed in 18 patients with wet AMD complicated by massive subretinal hemorrhages, who received as a treatment three monthly intravitreal ranibizumab injections. The first group (10 eyes) included patients with hemorrhages ranging from 1.5 to 3 disc diameters (DD), the second group (8 eyes) – patients with subretinal hemorrhage area of up to 1.5 DD. The age of patients varied from 65 to 83 years. The study was conducted using visometry, ophthalmoscopy of the damaged eye and of the fellow eye, as well as a monthly photo-registration of fundus and the OCT of macular area. The examinations were carried out before the treatment and 1 month after each ranibizumab IVI conducted by the standard technology in a sterile operating room.Results. After 3 monthly ranibizumab IVI in 8 patients of the second group the ophthalmoscopy showed a complete resorption of subretinal blood already after the 2nd ranibizumab IVI. According to the OCT a normalization of anatomy in the macular area was noted. Visometry results and patients subjectively reported a gradual improvement in visual acuity in the course of treatment, in some cases up to a full recovery by the end of the third month of therapy. A pigment epithelial tear, passing through the foveal zone, was detected in the treatment process associated with resorption of submacular clumps in 9 of 10 patients of the first group with areas of subretinal hemorrhages more than 1.5 DD. A complete attachment and a recovery profile of the foveal zone were not observed in any patients even after the full course of anti-VEGF therapy. A total hemophthalmus developed in one eye in the postinjection period that required the vitrectomy surgery. The visual acuity in patients of the first group decreased from 0.3 to0.15 in the anti-VEGF therapy in the majority of cases. At the same time all patients reported a subjective improvement in the quality of vision – a reduction of the size and intensity of the central scotoma darkening due to a resorption of subretinal blood in the central area of the retina.Conclusion. The therapy with intravitreal injections of ranibizumab is indicated and effective in patients with hemorrhages more than 1.5 DD. anti-VEGF therapy leads to an improvement in the life quality of patients and facilitates their adaptation to a visual impairment, due to a total or partial resorption of subretinal blood and a reduction in the area and intensity of the central scotoma

Stoffaustausch während der Filmabsorption : Absorption von Ammoniak durch Wasser und Salzsäure

Untersucht wurde die Absorption von Ammoniak aus der Luft durch Wasser und Säure in einem einzelnen Kanal (Rohr mit berieselbaren Wänden) und in einem Turm mit Blechpaketeinsatz. In der Untersuchung wurde der Einfluß der Strömungsgeschwindigkeit, der Gasgeschwindigkeit und der Kanalabmessungen auf den allgemeinen und partiellen Absorptionskoeffizienten bestimmt

Treatment of Patients with Acute Coronary Syndrome with ST Segment Elevation in Clinical Practice of the Republic of Karelia: the Results of 10-year Register

Aim. To study the clinical course, treatment, and outcomes in the patients with ST segment elevation acute coronary syndrome (STeACS) in real clinical practiceMaterial and methods. Our study is based on data of 5694 patients who were sequentially hospitalized in the Regional Vascular Center from 01.01.2009 to 01.01.2019 due to STeACS and included in the Federal Hospital Register. Men prevailed (65.8%); the average age was 68 years old. 14.1% of the patients had the history of myocardial infarction (MI) before this hospitalization. The reperfusion strategy, drug therapy, as well as the risks of complications and outcomes in real clinical practice of the Republic of Karelia were analyzed. Descriptive statistics methods were used to evaluate the results.Results. In the study group a high frequency of reperfusion interventions (83.5%) with a predominance of percutaneous coronary intervention (PCI; 76.2%) was revealed, as well as optimal drug therapy in most patients. Thus, 99.4% of patients took aspirin, 82.8% – clopidogrel, 91.1% – anticoagulants, 91.6% – beta-blockers, 95.6% – statins, 94.2% – angiotensin-converting-enzyme inhibitors/angiotensin II receptors blockers. A risk assessment of hospital and 6-month mortality was performed using GRACE score. The distribution of the hospital risk mortality were the following: 25.7% of patients had a low (49-125 points), 33.7% an average (126-154 points), and 40.6% of patients had a high risk (more than 154 points). At the same time, the risk of 6-month mortality in a half of the patients (51.6%) was low (27-99 points), the average risk (100-127 points) was determined in 23.0% of patients and the high risk (more than 127 points) – in 25.5% of patients. Life threatening complications developed in 38.1% of patients and the most frequent ones were arrhythmias (31.5%). The outcomes at the discharge from the hospital were as follows: 1432 patients (63.5%) had Q MI, 390 (17.3%) – non Q MI, 76 (3.4%) – unstable angina, 21 (0.9%) – MI of unspecified localization and 317 patients (14.1%) – repeated myocardial infarction.Conclusion. According to the results of a 10-year hospital registry of patients with STeACS, a high frequency of reperfusion interventions and an optimal drug therapy in most patients was revealed. However, to increase the effectiveness of treatment, it is necessary to minimize temporary losses both at the prehospital treatment and during reperfusion