Technology entrepreneurship as a factor of sustainable energy in smart cities

The implementation of intelligent engineering infrastructure in cities necessitates the involvement of a large number of various innovative organizations. The experience of pioneer smart cities and global companies that are developing smart technologies shows that the key role in that process is played by technology entrepreneurs, i.e., a community of innovators who are capable of rapidly creating breakthrough solutions, launching them into the market, adopting and commercializing them. This study analyzes the theoretical features and current essential tasks of tech entrepreneurship as a business phenomenon and ways and means for technology entrepreneurship by corporations and independent start-ups. Exploring the case of the energy sector in smart cities which presents a growing market for technology solutions, the authors reveal the structure of the main segments of technology entrepreneurship, including electric vehicles and charging infrastructure, smart metering, telemetering, demand side management, distributed generation and micro-grids. Examples are described of tech entrepreneurship projects that were implemented by energy and telecom companies with the purpose of making urban energy smarter and more sustainable. © 2020 WIT Press.The work was supported by Act 211 of the Government of the Russian Federation, contract No. 02.A03.21.0006

Глобальный рынок образовательных продуктов в it-сфере: приоритеты для российских университетов

The article describes the key trends in education for the IT and radio electronics sectors, considers the comparative analysis of approaches to organization of scientific and educational activities in 30 foreign and domestic universities leading in subject ratings of QS Computer Science & Information Systems and Engineering – Electrical & Electronic. Characteristics of the trends are: • close and constantly increasing integration of educational and scientific fields of activity, which is reflected in the emergence of interdisciplinary educational programs, linking the educational process to research in breakthrough areas of knowledge and the formation of specific university ecosystems aimed at leadership in specific technologies; • the variety of forms of organization of the educational process, the orientation towards modularity, individuality and continuity, which are actively used in the promotion of educational services; • the general backlog of Russian universities from IT practice and expectations of the real sector. The research methodology included analysis of the content and models for the implementation of educational products, expert opinions on the requirements for the formation of IT professionals. As a result, disparities between current industry trends, the current situation in education and demands of the real sector were defined. In the context of the example of a number of master’s programs developed at the Institute of Radioelectronics and Information Technologies of the Ural Federal University, a mechanism for integrating science, education and consulting in order to develop highly-demanded interdisciplinary educational products has been demonstrated. The results of the research can be used by domestic and foreign universities working in IT-segments, to increase competitiveness and implement strategic scientific and educational initiatives.В статье рассмотрены ключевые тренды в образовании для отраслей IT и радиоэлектроники, проведен сравнительный анализ подходов к организации научно-образовательной деятельности в 30 зарубежных и отечественных университетах, лидирующих в предметных рейтингах QS Computer Science & Information Systems и Engineering – Electrical&Electronic. Характеристиками трендов являются:• тесная и постоянно усиливающаяся интеграция образовательной и научной сфер деятельности, что выражается в появлении междисциплинарных образовательных программ, привязке учебного процесса к исследованиям в прорывных областях знаний и формировании специфических университетских экосистем, нацеленных на лидерство в конкретных технологиях;• разнообразие форм организации учебного процесса, ориентация на модульность, индивидуальность и непрерывность, которые активно используются в продвижении образовательных услуг;• общее отставание российских университетов от IT-практики и ожиданий реального сектора.Методика исследования предусматривала анализ содержания и моделей реализации образовательных продуктов, экспертных мнений в части требований к образованию IT-специалистов. В результате определены разрывы между актуальными отраслевыми трендами, текущей ситуацией в образовании и запросами реального сектора. На примере ряда магистерских программ, разработанных в Институте радиоэлектроники и информационных технологий Уральского федерального университета, продемонстрирован механизм интеграции науки, образования и консалтинга с целью развить востребованные междисциплинарные образовательные продукты. Результаты исследования могут быть использованы отечественными и зарубежными университетами, работающими в IT-сегментах, для повышения конкурентоспособности и реализации стратегических научно-образовательных инициатив

Combined effects of oncolytic vaccinia virus and dendritic cells on the progression of melanoma B16-F10 in mice

Aim: We aimed to test the hypothesis that loading of dendritic cells (DCs) with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic virus.Methods: Vaccinia virus LIVP/GFP and melanoma B16-F10 were used in this study. DCs were pulsed with various combinations of viral and tumor-associated antigens. The maturation status of DCs was verified by expression of the markers CD80, CD86, and CCR7 and assessment of IL-6, TNF-α, and IL-12 secretion. The most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T lymphocytes. Combination therapy using vaccinia virus LIVP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor model.Results: We found that loading of DCs with viral antigens, or with a combination of viral and tumor antigens, resulted in similar levels of expression of DC maturation markers. The maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia virus LIVP/GFP infected tumor cell. The results show that the combination of vaccinia virus LIVP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than two-fold.Conclusions: Combination therapy with oncolytic vaccinia virus LIVP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10, but no synergistic antitumor effects were observed. We propose that optimization of the therapy regimen could enhance the efficiency of combination therapy

THE IMPACT OF COVID-19 ON THE DEVELOPMENT OF TELECOMMUNICATIONS COMPANIES IN RUSSIA

The article contains an analysis of the functioning of the Russian IT sector and the changes that have occurred in it under the influence of the coronavirus pandemic. The authors concluded that the consequences of the pandemic for telecommunications companies are controversial. On the one hand, over the period of the pandemic, the IT market has shrunk by 5%, at the same time, favorable conditions have been created for the development of telecommunications, industry solutions (corporate software), and IT services.В статье содержится анализ функционирования российского IT-сектора и происшедших на нем изменений под влиянием пандемии коронавируса. Авторами сделан вывод о том, что последствия пандемии для телекоммуникационных компаний имеют неоднозначный характер. С одной стороны, за период пандемии рынок IT сократился на 5%, вместе с тем созданы благоприятные условия для развития телекоммуникаций, отраслевых решения (корпоративно ПО), IT сервисов

Global market of educational products in the it sphere: priorities for russian universities

The article describes the key trends in education for the IT and radio electronics sectors, considers the comparative analysis of approaches to organization of scientific and educational activities in 30 foreign and domestic universities leading in subject ratings of QS Computer Science & Information Systems and Engineering – Electrical & Electronic. Characteristics of the trends are: • close and constantly increasing integration of educational and scientific fields of activity, which is reflected in the emergence of interdisciplinary educational programs, linking the educational process to research in breakthrough areas of knowledge and the formation of specific university ecosystems aimed at leadership in specific technologies; • the variety of forms of organization of the educational process, the orientation towards modularity, individuality and continuity, which are actively used in the promotion of educational services; • the general backlog of Russian universities from IT practice and expectations of the real sector. The research methodology included analysis of the content and models for the implementation of educational products, expert opinions on the requirements for the formation of IT professionals. As a result, disparities between current industry trends, the current situation in education and demands of the real sector were defined. In the context of the example of a number of master’s programs developed at the Institute of Radioelectronics and Information Technologies of the Ural Federal University, a mechanism for integrating science, education and consulting in order to develop highly-demanded interdisciplinary educational products has been demonstrated. The results of the research can be used by domestic and foreign universities working in IT-segments, to increase competitiveness and implement strategic scientific and educational initiatives