18 research outputs found
Problems of for mation of the System of Local Self-Government of Russia: Theory and Reality
The article deals with the main problems of formation and effective functioning of the system of local self-government. Features of activity of system of this level of the power in modern Russian practice are noted.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΌΠΎΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ. ΠΡΠΌΠ΅ΡΠ΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π²Π»Π°ΡΡΠΈ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅
Identification and Intraspecific Typing of Plague Microbe Strains with Their Potential Virulence Determination Using PCR
Developed is the method of identification and intraspecific typing of plague microbe strains along with their potential virulence determination. Intraspecific differentiation and focal attribution of the examined plague microbe strains can be determined by monolocus VNTR-PCR, and main virulence determinants (chromosomal pigmentation region and calcium-dependence plasmid genes) - by multiplex PCR
Experimental Substantiation of the Possibility to Use Finite Cell Line CHO-K1 for Determination of Specific Activity of Components of Chemical Cholera Vaccine
Objective was to experimentally substantiate the possibility to use the finite cell line CHO-K1 for measuring specific activity of cholera toxin and component of the vaccine choleragen-anatoxin in the process of chemical cholera vaccine manufacturing. Materials and methods. The studies involved the finite cell line CHO-K. The registration of results of bio-indication method was performed visually with the help of inverted microscope and photometrically - in colorimetric test for the assessment of metabolic activity of the cells at the wave length of 595 nm. Results and discussion. The proposed method allows for determining the toxin-production activity of Vibrio cholerae 569B strain during submerged cultivation in bioreactor and specific activity of choleragen-anatoxin by anatoxin binding measuring using cell cultures. The results correlate with the data obtained using intradermal Craigβs technique, GM1-ELISA and radial passive immune hemolysis (RPIH). Introduction of cell culture method into practice will provide for significant decrease in the volumes of usage of animals at the stages of manufacturing of chemical bivalent cholera vaccine
Investigating the stability of the Properties of Vibrio cholerae strains β Producers of Active Components of the Chemical Cholera Vaccine
One of the key requirements to producer strains used in the manufacturing of immunobiological preparations is their stability, which consists in maintaining the main cultural, morphological, physiological, and productive properties in a series of generations. This paper describes a comprehensive methodological approach to testing strain stability using in vitro techniques.The purpose of this study was to conduct an integrated analysis of the stability in the strains that produce active components of the chemical cholera vaccine when preparing seed material and at the stage of cultivation.Materials and methods. Toxigenic strains of Vibrio Ρholerae 569B of the classical biovar, serovar Inaba and V. Ρholerae M-41 of the classical biovar, serovar Ogawa were used in the work. Cell morphology was monitored through light and transmission electron microscopy. Atomic force microscopy was applied to measure the main parameters of the bacterial cell. The strains were tested for the presence of ctxA gene in the chromosome using the βGenCholβ test system with electrophoretic registration of results. Whole genome sequencing of the strains was performed on the Ion Torrent PGM platform using the Ion 318 Chip Kit and the Ion PGM Hi-Q View Chef 400 Kit. To determine the specific activity of cholera toxin and O-antigen, a DOT immunoassay with a conjugate based on staphylococcal protein A and colloidal gold nanoparticles was applied.Results and discussion. The stability of the main properties of industrial V. Ρholerae strains β producers of the active components of the chemical cholera vaccine has been confirmed using microbiological, immunochemical, molecular-genetic methods and microscopic analysis at all stages of cultivation, and the prospects for using the integrated methodological approach experimentally substantiated. Tailoring of these methods will make it possible to control the stability of producer strains, optimize cultivation conditions and, as a result, increase the yield of the necessary antigenic component of the vaccine
The Β«noise pollutionΒ» of the department of resuscitation(NICU)
The objective of research consisted in definition of levels of noise during a regular operating mode of branch of resuscitation of newborn, revealing of dependence of noise level from time of days, quantity of patients, the employees, the functioning equipment, intensity of work, the area of chambers; allocation of the basic sources "noise pollutionΒ» and substantiations of carrying out of preventive actions on decreasing noise level. Materials and research methods: measurements of noise levels in resuscitation chambers and adjacent premises with them during a regular operating mode of branch of resuscitation of newborns and preterm baby were doing. The minimum and maximum noise was investigated in an operating time of the basic and auxiliary the resuscitation equipment in a constant-variable mode, and noise was made by employees in the course of intensive treatment, care of newborn children and procedural nurse-engineering and organizational actions. The level of noise of functional premises NICU within days at constantly working respiratory devices, incubators for newborns, monitors and additional the equipment in presence and without employees are defined in a range 46 - 66 dBA. The level of peak noise in resuscitation chambers at activation of signals of monitors and devices IVL working suction, equipment movement, at carrying out resuscitation action with children, conversations and vocal commands was defined in a range - 62 - 94 dBA without dependence from time of days, quantity of patients and employees and the functioning equipment. Results of research have shown high level Β«noise pollutionΒ» in resuscitation branch at any time. Noise levels depend on branch operating mode. At a super intensive mode, when patients come in ,or the maximum monitor and handling activity work, or all children demands artificial ventilation of the lungs with the expanded monitor support) noise was above, than in chambers of intensive therapy, when children are on independent breath and get infusional therapy and feeding). Deducing of a chamber of compressors from the basic premises, transition to is centralized the system of maintenance with medical gases, regulation of level of signals of monitors, protective noisy absorbing covers for incubators, rational arrangementing of the equipment, refusal of the expanded consultations and discussion at bed of the patient, refusal of selector communication and telephone calling in branch, formation of βquiet time' allow to lower noise level on 25 - 50 %.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π·Π°ΠΊΠ»ΡΡΠ°Π»Π°ΡΡ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠΌΠ° Π² ΡΡΠ°ΡΠ½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ°Π±ΠΎΡΡ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄ΡΠ½Π½ΡΡ
, Π²ΡΡΠ²Π»Π΅Π½ΠΈΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΡΡΠΎΠ²Π½Ρ ΡΡΠΌΠ° ΠΎΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΡΡΠΎΠΊ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
, ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ², ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π±ΠΎΡΡ, ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΠΏΠ°Π»Π°Ρ; Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² Β«ΡΡΠΌΠΎΠ²ΠΎΠ³ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡΒ» ΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΏΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΡΠΌΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΡΠΌΠ° Π² ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°Π»Π°ΡΠ°Ρ
ΠΈ ΡΠΌΠ΅ΠΆΠ½ΡΡ
Ρ Π½ΠΈΠΌΠΈ ΠΏΠΎΠΌΠ΅ΡΠ΅Π½ΠΈΡΡ
Π² ΡΡΠ°ΡΠ½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ°Π±ΠΎΡΡ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄ΡΠ½Π½ΡΡ
ΠΈ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΡΡ ΠΊΠΎΡΡΠΈΠ³ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ, ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ ΡΡΠΌ, Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΡΠ°Π±ΠΎΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΈ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎ-ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅, Π° ΡΠ°ΠΊ ΠΆΠ΅ ΡΡΠΌ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΡΠΉ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΡ
ΠΎΠ΄Π° Π·Π° Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄ΡΠ½Π½ΡΠΌΠΈ Π΄Π΅ΡΡΠΌΠΈ ΠΈ ΡΠ΅Π³Π»Π°ΠΌΠ΅Π½ΡΠ½ΡΡ
ΡΠ°Π½ΠΈΡΠ°ΡΠ½ΠΎ-ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ. Π£ΡΠΎΠ²Π½ΠΈ ΠΊΠΎΡΡΠΈΠ³ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΠΌΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΏΠΎΠΌΠ΅ΡΠ΅Π½ΠΈΠΉ ΠΠ ΠΠ’Π Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠΎΠΊ ΠΏΡΠΈ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎ ΡΠ°Π±ΠΎΡΠ°ΡΡΠΈΡ
ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ²Π°Ρ
Π΄Π»Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΠΈΠ½ΠΊΡΠ±Π°ΡΠΎΡΠ°Ρ
Π΄Π»Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄ΡΠ½Π½ΡΡ
, ΠΌΠΎΠ½ΠΈΡΠΎΡΠ°Ρ
ΠΈ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΠΈ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ ΠΈ Π±Π΅Π· ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ 46 - 66 Π΄ΠΠ. Π£ΡΠΎΠ²Π½ΠΈ ΠΏΠΈΠΊΠΎΠ²ΡΡ
ΡΡΠΌΠΎΠ² Π² ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°Π»Π°ΡΠ°Ρ
ΠΏΡΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΌΠΎΠ½ΠΈΡΠΎΡΠΎΠ² ΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΠ/1, ΡΠ°Π±ΠΎΡΠ°ΡΡΠΈΡ
Π°ΡΠΏΠΈΡΠ°ΡΠΎΡΠ°Ρ
, ΠΏΠ΅ΡΠ΅Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ Ρ Π΄Π΅ΡΡΠΌΠΈ, ΡΠ°Π·Π³ΠΎΠ²ΠΎΡΠ°Ρ
ΠΈ Π³ΠΎΠ»ΠΎΡΠΎΠ²ΡΡ
ΠΊΠΎΠΌΠ°Π½Π΄Π°Ρ
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΡΡ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ - 62 - 94 Π΄ΠΠ Π²Π½Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΡΡΠΎΠΊ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Β«ΡΡΠΌΠΎΠ²ΠΎΠ³ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡΒ» Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ Π² Π»ΡΠ±ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠΎΠΊ. Π£ΡΠΎΠ²Π½ΠΈ ΡΡΠΌΠ° Π·Π°Π²ΠΈΡΠ΅Π»ΠΈ ΠΎΡ ΡΠ΅ΠΆΠΈΠΌΠ° ΡΠ°Π±ΠΎΡΡ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ. ΠΡΠΈ ΡΡΠΏΠ΅ΡΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅ (ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΠΌΠΎΠ½ΠΈΡΠΎΡΠ½Π°Ρ ΠΈ ΠΌΠ°Π½ΠΈΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π²ΡΠ΅ Π΄Π΅ΡΠΈ Π½Π° ΠΠΠ Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΡΠΌ ΠΌΠΎΠ½ΠΈΡΠΎΡΠ½ΡΠΌ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ) ΡΡΠΌ Π±ΡΠ» Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π² ΠΏΠ°Π»Π°ΡΠ°Ρ
ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (Π΄Π΅ΡΠΈ Π½Π° ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΠΎΠΌ Π΄ΡΡ
Π°Π½ΠΈΠΈ, Π½Π° ΠΈΠ½ΡΡΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ ΠΈ ΡΠ½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΠΈ). ΠΡΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΏΠ°Π»Π°ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΡΠ΅ΡΡΠΎΡΠΎΠ² ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΏΠΎΠΌΠ΅ΡΠ΅Π½ΠΈΠΉ, ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ Π½Π° ΡΠ΅Π½ΡΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΌΠΈ Π³Π°Π·Π°ΠΌΠΈ, ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΌΠΎΠ½ΠΈΡΠΎΡΠΎΠ², Π·Π°ΡΠΈΡΠ½ΡΠ΅ ΡΡΠΌΠΎΠΏΠΎΠ³Π»ΠΎΡΠ°ΡΡΠΈΠ΅ ΡΠ΅Ρ
Π»Ρ Π½Π° ΠΈΠ½ΠΊΡΠ±Π°ΡΠΎΡΡ, ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ° ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΎΡΠΊΠ°Π· ΠΎΡ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΡΡ
ΠΊΠΎΠ½ΡΠΈΠ»ΠΈΡΠΌΠΎΠ² ΠΈ ΠΎΠ±Ρ
ΠΎΠ΄ΠΎΠ² Ρ ΠΏΠΎΡΡΠ΅Π»ΠΈ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ, ΠΎΡΠΊΠ°Π· ΠΎΡ ΡΠ΅Π»Π΅ΠΊΡΠΎΡΠ½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΈ ΡΠ΅Π»Π΅ΡΠΎΠ½Π½ΡΡ
ΠΏΠ΅ΡΠ΅Π³ΠΎΠ²ΠΎΡΠΎΠ² Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ, ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Β«ΡΠΈΡ
ΠΈΡ
ΡΠ°ΡΠΎΠ²Β» ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ½ΠΈΠ·ΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΡΠΌΠ° Π½Π° 25 β 50%
Use be-level nasal cpap with variable flow in preterm infants after extubation: a multicentred randomized clinical trial
In order to determine optimal methods of extubation in preterm infants who less than 1500 grams we studied 121 infants, who transferred after mechanical ventilation to noninvasive respiratory therapy: CPAP (n=55) and bi-level CPAP with variable flow or BiPhasic (n=66). It has been proven that premature infants were extubated on BiPhasic, have less risk of reintubation within the first 72 hours (p = 0.032). As a result, we concluded that the use of BiPhasic with variable flow is more efficient method compared to conventional CPAP with variable flow in preterm infants who required prolonged mechanical ventilation.Π‘ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΊΡΡΡΠ±Π°ΡΠΈΠΈ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
Ρ ΠΌΠ°ΡΡΠΎΠΉ ΡΠ΅Π»Π° ΠΌΠ΅Π½Π΅Π΅ 1500 Π³ΡΠ°ΠΌΠΌΠΎΠ² Π½Π°ΠΌΠΈ Π±ΡΠ» ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ 121 ΡΠ΅Π±Π΅Π½ΠΎΠΊ, ΠΏΠ΅ΡΠ΅Π²Π΅Π΄Π΅Π½Π½ΡΠΉ ΡΡΠ°Π·Ρ ΠΏΠΎΡΠ»Π΅ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
Π½Π° Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ: Π‘Π ΠΠ (n=55) ΠΈ Π΄Π²ΡΡ
ΡΡΠΎΠ²Π½Π΅Π²ΡΠΉ Π‘Π ΠΠ Ρ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΡΠΌ ΠΏΠΎΡΠΎΠΊΠΎΠΌ ΠΈΠ»ΠΈ BiPhasic (n=66). ΠΡΠ»ΠΎ Π΄ΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΠ΅ Π΄Π΅ΡΠΈ, ΡΠΊΡΡΡΠ±ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½a BiPhasic, ΠΈΠΌΠ΅ΡΡ ΠΌΠ΅Π½ΡΡΠΈΠΉ ΡΠΈΡΠΊ ΡΠ΅ΠΈΠ½ΡΡΠ±Π°ΡΠΈΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ²ΡΡ
72 ΡΠ°ΡΠΎΠ² (Ρ=0,032). Π ΠΈΡΠΎΠ³Π΅ ΠΌΡ ΠΏΡΠΈΡΠ»ΠΈ ΠΊ Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ BiPhasic Ρ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΡΠΌ ΠΏΠΎΡΠΎΠΊΠΎΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠΌ Π‘Π ΠΠ Ρ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΡΠΌ ΠΏΠΎΡΠΎΠΊΠΎΠΌ Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ, Π½ΡΠΆΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π² Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
Depressions in patients with essential hypertension complicated by chronic heart failure
Depressive disorders were detected in 48 (63.2%) of 76 patients (70 women and 6 men) with essential hypertension complicated by diastolic heart failure. The quality of life and the degree of chronic heart failure and depressive disorders were estimated at the inclusion of the patients into the study and then 3 months after therapy with the antidepressant pyrazidole. Moderate depressive disorders reduced exercise tolerance. The degree of depressive disorders was found to be directly related to worse quality of life. During combination psychotropic and basic treatment, there were improvements in the characteristics of physical and mental status and in quality of life in the patients