8 research outputs found
Levels of chemokines and other inflammatory mediators in patients with mild cognitive impairment undergoing rehabilitation
Alzheimer's disease is the most common neurodegenerative disease in old age. In some cases, it is preceded by mild cognitive impairment (MCI). One of the important components in the pathogenesis of neurodegeneration is chronic neuroinflammation (inflammatory activation of microglia and astrocytes in the brain). Systemic inflammatory response and immune dysregulation may contribute to neuroinflammation. The purpose of this study was to investigate the level of chemokines and other inflammatory mediators in patients with MCI who underwent medical rehabilitation, and to study its associations with the severity of cognitive impairment. The study group included 48 patients with MCI undergoing rehabilitation. Rehabilitation included cognitive therapy, psychotherapy and tasks for unaided performance. Repeated examination was conducted 6 months after the completion of rehabilitation. The control group included 46 healthy volunteers. Multiplex assay was used to determine serum cytokine and chemokine concentrations. Student's t-test was used to assess the significance of differences. Assessment of cognitive functions was performed using international neuropsychological scales. In patients with MCI, we have found an increase in the levels of several cytokines and chemokines (TNFΞ±, CXCL10/IP10, MDC) that regulate systemic inflammation, cellular and humoral mechanisms of adaptive immunity. After the rehabilitation course their levels returned to normal. It was also found that decrease in CCL7 level in the patients before the rehabilitation course is associated with the severity of cognitive impairment. The findings contribute to understanding the role of chemokines in the pathogenesis of MCI, and indicate that their levels can be potential biomarkers of the severity of cognitive impairment. For translation of the findings into clinical practice, their validation in larger studies is needed, as well as assessing the associations between chemokine levels and the severity of cognitive impairment in MCI over long-term follow-up
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π±ΠΈΠΎΠ΄ΠΈΠ·Π΅Π»Ρ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ Π² Π°ΠΏΠΏΠ°ΡΠ°ΡΠ΅ Ρ Π²ΠΈΡ ΡΠ΅Π²ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ
The possibility of intensifying the process of transesterification of triglycerides of carboxylic acids of vegetable oils with alcohols C1-C3 in the presence of potassium hydroxide in an apparatus with a vortex sheet is shown. Analysis of the composition of mixtures of methyl esters of carboxylic acids of sunflower oil showed that the redistribution of hydrogen and the destructive transformation in the system take place along with the transesterification reactions. This results in the expenditure of octadecyl acid ether.ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΠ΅ΡΠ΅ΡΡΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΡΠΈΠ³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ² ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΠ΅Π» ΡΠΏΠΈΡΡΠ°ΠΌΠΈ Π‘1-Π‘3 Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ΄Π° ΠΊΠ°Π»ΠΈΡ Π² Π°ΠΏΠΏΠ°ΡΠ°ΡΠ΅ Ρ Π²ΠΈΡ
ΡΠ΅Π²ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ. ΠΠ½Π°Π»ΠΈΠ· ΡΠΎΡΡΠ°Π²Π° ΡΠΌΠ΅ΡΠ΅ΠΉ ΠΌΠ΅ΡΠΈΠ»ΠΎΠ²ΡΡ
ΡΡΠΈΡΠΎΠ² ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΏΠΎΠ΄ΡΠΎΠ»Π½Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π° ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ Π½Π°ΡΡΠ΄Ρ Ρ ΠΏΠ΅ΡΠ΅ΡΡΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° ΠΈ Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠΈΠ΅ ΠΊ ΠΈΡΡΠ΅Π·Π½ΠΎΠ²Π΅Π½ΠΈΡ Π² Π±ΠΈΠΎΠ΄ΠΈΠ·Π΅Π»Π΅ ΠΌΠ΅ΡΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΈΡΠ° ΠΎΠΊΡΠ°Π΄Π΅ΡΠ΅Π½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
The features of producing the first generation biodiesel in an apparatus with a vortex sheet
The possibility of intensifying the process of transesterification of triglycerides of carboxylic acids of vegetable oils with alcohols C1-C3 in the presence of potassium hydroxide in an apparatus with a vortex sheet is shown. Analysis of the composition of mixtures of methyl esters of carboxylic acids of sunflower oil showed that the redistribution of hydrogen and the destructive transformation in the system take place along with the transesterification reactions. This results in the expenditure of octadecyl acid ether
Erosion processes on the hydraulic-mine dump "Beryozovy log" KMA and how to struggle against them
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΡ Π²Π΅ΡΡΠΎΠ²ΠΎΠΉ ΠΈ Π²ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΠ·ΠΈΠΈ, ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠΈΠ΅ Π½Π° Π³ΠΈΠ΄ΡΠΎΠΎΡΠ²Π°Π»Π΅ Π²ΠΎ Π²ΡΠ΅ΠΌΡ Π΅Π³ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π³ΠΎΡΠ½ΠΎΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΠΊΡΠ»ΡΡΠΈΠ²Π°ΡΠΈΠΈ. ΠΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ, ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ ΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½Π°Ρ ΡΠ΅ΠΊΡΠ»ΡΡΠΈΠ²Π°ΡΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΎΡΠ²Π°Π»Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΡΡΠ°Π½ΠΈΡΡ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· ΠΎΠΏΠ°ΡΠ½Π΅ΠΉΡΠΈΡ
Π² ΡΠ°ΠΉΠΎΠ½Π΅ ΠΠΠ ΠΎΡΠ°Π³ΠΎΠ² ΡΡΠΎΠ·ΠΈΠΈ ΠΈ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π΅Π³ΠΎ Π² Π½Π°ΡΠΎΠ΄Π½ΠΎΠΌ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅.The proccesses of wind and hydro erosion on the hydraulic-mine dump during its formation and realization of mining and biological recultivation are considered. Positive and negative aspects of the recultivation regarding erosion processes are noted. Qualitative, timely and integrated recultivation of the hydraulic-mine dump makes it possible to eliminate one of the most dangerous centres of erosion in the KMA region and use it rationally in the national economy