29 research outputs found
Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of the CCR5 coding region alleles in South Brazil and noticed a high CCR5*D32 frequency in the Euro-Brazilian population of the ParanĂĄ State (9.3%), which is the highest thus far reported for Latin America. The D32 frequency is even higher among the Euro-Brazilian Mennonites (14.2%). This allele is uncommon in Afro-Brazilians (2.0%), rare in the Guarani Amerindians (0.4%) and absent in the Kaingang Amerindians and the Oriental-Brazilians. R223Q is common in the Oriental-Brazilians (7.7%) and R60S in the Afro-Brazilians (5.0%). A29S and L55Q present an impaired response to ÎČ-chemokines and occurred in Afro- and Euro-Brazilians with cumulative frequencies of 4.4% and 2.7%, respectively. Two new non-synonymous alleles were found in Amerindians: C323F (g.3729G > T) in Guarani (1.4%) and Y68C (g.2964A > G) in Kaingang (10.3%). The functional characteristics of these alleles should be defined and considered in epidemiological investigations about HIV-1 infection and AIDS incidence in Amerindian populations
Signal transducer and activator of transcription 3 (STAT3) promoter methylation and expression in pituitary adenoma
BI-04 * PRE-OPERATIVE LOW TRI-IODOTHYRONINE SYNDROME IS ASSOCIATED WITH GREATER 6-MONTH MORTALITY RATE OF NEUROSURGICAL BRAIN TUMOR PATIENTS
QL-06 * RELIABILITY OF THE SF-36 QUESTIONNAIRE FOR ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN NEUROSURGICAL BRAIN TUMOR PATIENTS
Management of Patients with Ruptured Cerebral Aneurysms in Hospital Population of Lithuania
Hilum of the heart
Qui a fermĂ© les portes de la mer ?Livre de Job RiviĂšres, canaux, sources ou puits, nous connaissons mieux maintenant lâeau en travail sur la terre que Dieu a donnĂ©e aux hommes. ĂlĂ©ment essentiel de la composition de lâunivers, elle est, dâabord, mouvement toujours recommencĂ©Â : pluie, ruissellement, disparition, rĂ©surgence, Ă©vaporation et pluie encore. MĂȘme si ce grand cycle se suspend par instants pour retenir lâeau au trĂ©fonds du sol, avant de la relĂącher de nouveau Ă lâair libre, câest bien..