Related Circuitry and Synaptic Connectivity in Psychiatric Disorders

Library of Congress Control Number: 2014953249International audienceDeciphering the connectivity supporting brain function in psychiatric disorders is one of the major challenges in clinical neurosciences. Neural correlates of psychiatric disorders are not well-known because experimental research is extremely difficult to carry on facing the complexity of biological, medical and socio-psychological concepts. Although far from an extensive knowledge of such complex issue, one can summarize most main macroscopic or microscopic circuits known in human and higher species, but also in rodents. After a reminder of scales and functionality of neurobiological circuits, anatomo-functional correlates of the executive-behavioral system and psychiatric disorders are exposed, focusing on most frequent domains of psychiatry, anxiety, mood, substance disorders and memory