1,541 research outputs found
Low-Complexity Detection/Equalization in Large-Dimension MIMO-ISI Channels Using Graphical Models
In this paper, we deal with low-complexity near-optimal
detection/equalization in large-dimension multiple-input multiple-output
inter-symbol interference (MIMO-ISI) channels using message passing on
graphical models. A key contribution in the paper is the demonstration that
near-optimal performance in MIMO-ISI channels with large dimensions can be
achieved at low complexities through simple yet effective
simplifications/approximations, although the graphical models that represent
MIMO-ISI channels are fully/densely connected (loopy graphs). These include 1)
use of Markov Random Field (MRF) based graphical model with pairwise
interaction, in conjunction with {\em message/belief damping}, and 2) use of
Factor Graph (FG) based graphical model with {\em Gaussian approximation of
interference} (GAI). The per-symbol complexities are and
for the MRF and the FG with GAI approaches, respectively, where
and denote the number of channel uses per frame, and number of transmit
antennas, respectively. These low-complexities are quite attractive for large
dimensions, i.e., for large . From a performance perspective, these
algorithms are even more interesting in large-dimensions since they achieve
increasingly closer to optimum detection performance for increasing .
Also, we show that these message passing algorithms can be used in an iterative
manner with local neighborhood search algorithms to improve the
reliability/performance of -QAM symbol detection
Improving dialysis adherence for high risk patients using automated messaging: Proof of concept
AbstractComorbidities and socioeconomic barriers often limit patient adherence and self-management with hemodialysis. Missed sessions, often associated with communication barriers, can result in emergency dialysis and avoidable hospitalizations. This proof of concept study explored using a novel digital-messaging platform, EpxDialysis, to improve patient-to-dialysis center communication via widely available text messaging and telephone technology. A randomized controlled trial was conducted through Washington University-affiliated hemodialysis centers involving ESRD patients with poor attendance, defined as missing 2â6 sessions over the preceding 12 weeks. A cross-over study design evaluated appointment adherence between intervention and control groups. Comparing nonadherence rates eight weeks prior to enrollment, median appointment adherence after using the system increased by 75%, and median number of unintended hospitalization days fell by 31%. A conservative cost-benefit analysis of EpxDialysis demonstrates a 1:36 savings ratio from appointment adherence. EpxDialysis is a low-risk, cost-effective, intervention for increasing hemodialysis adherence in high-risk patients, especially at centers caring for vulnerable and low-income patients.</jats:p
Modeling cancer metabolism on a genome scale
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last decade, leading to the recognition that altered tumor metabolism is one of the hallmarks of cancer. Deciphering the full scope and functional implications of the dysregulated metabolism in cancer requires both the advancement of a variety of omics measurements and the advancement of computational approaches for the analysis and contextualization of the accumulated data. Encouragingly, while the metabolic network is highly interconnected and complex, it is at the same time probably the best characterized cellular network. Following, this review discusses the challenges that genomeâscale modeling of cancer metabolism has been facing. We survey several recent studies demonstrating the first strides that have been done, testifying to the value of this approach in portraying a networkâlevel view of the cancer metabolism and in identifying novel drug targets and biomarkers. Finally, we outline a few new steps that may further advance this field
Codon Distributions in DNA
The codons, sixtyfour in number, are distributed over the coding parts of DNA
sequences. The distribution function is the plot of frequency-versus-rank of
the codons. These distributions are characterised by parameters that are almost
universal, i.e., gene independent. There is but a small part that depends on
the gene. We present the theory to calculate the universal (gene-independent)
part. The part that is gene-specific, however, has undetermined overlaps and
fluctuations.Comment: 31 pages, 5 figure
Condensation of Excitons in Cu2O at Ultracold Temperatures: Experiment and Theory
We present experiments on the luminescence of excitons confined in a
potential trap at milli-Kelvin bath temperatures under cw-excitation. They
reveal several distinct features like a kink in the dependence of the total
integrated luminescence intensity on excitation laser power and a bimodal
distribution of the spatially resolved luminescence. Furthermore, we discuss
the present state of the theoretical description of Bose-Einstein condensation
of excitons with respect to signatures of a condensate in the luminescence. The
comparison of the experimental data with theoretical results with respect to
the spatially resolved as well as the integrated luminescence intensity shows
the necessity of taking into account a Bose-Einstein condensed excitonic phase
in order to understand the behaviour of the trapped excitons.Comment: 41 pages, 23 figure
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