3 research outputs found
ΠΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠ²ΡΠΉ ΡΡΠ°ΡΡΡ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠΈΠΌ Π³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΡΠΌ Π³Π΅ΡΠΏΠ΅ΡΠΎΠΌ ΠΏΡΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ Π»ΠΈΠΏΠΎΡΠΎΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π ΠΠ
The aim of this study was the estimation of the influence of liposomal ribonucleic acid (RNA) medicine Β«LiprinaΒ» on interferon status of women with recurrent genital herpes. In this study 60 women were included, who combined (acyclovir and Liprina, nΒ =Β 40) or monoterapy with acyclovir (nΒ =Β 20) were received. The levels of serum interferon alpha and gamma along with cervical virus elimination were estimated. The medicine Β«LiprinaΒ» increased the therapy efficiency of the women with genital herpes, that perhaps related with endogen interferon production amplification.ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π»ΠΈΠΏΠΎΡΠΎΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΈΠ±ΠΎΠ½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ (Π ΠΠ) Β«ΠΠΈΠΏΡΠΈΠ½Π°Β» Π½Π° ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠ²ΡΠΉ ΡΡΠ°ΡΡΡ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠΈΠΌ Π³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΡΠΌ Π³Π΅ΡΠΏΠ΅ΡΠΎΠΌ. ΠΡΠ»ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 60 ΠΆΠ΅Π½ΡΠΈΠ½, ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
40 ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ (Π°ΡΠΈΠΊΠ»ΠΎΠ²ΠΈΡ ΠΈ Π»ΠΈΠΏΡΠΈΠ½Π°) ΠΈ 20 β ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ Π°ΡΠΈΠΊΠ»ΠΎΠ²ΠΈΡΠΎΠΌ. ΠΠ·ΡΡΠ΅Π½ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΡΡ
ΡΡΠΎΠ²Π½Π΅ΠΉ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠ²-Ξ± ΠΈ -Ξ³ Π½Π°ΡΡΠ΄Ρ Ρ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΠ΅ΠΉ Π²ΠΈΡΡΡΠ° ΠΈΠ· ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Β«ΠΠΈΠΏΡΠΈΠ½Π°Β» ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ Π³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΠΎΠΌ Π³Π΅ΡΠΏΠ΅ΡΠ΅, ΡΡΠΎ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ΠΌ Π²ΡΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½ΠΎΠ²
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° ΠΏΡΠΎΡΡΠ°Π³Π»Π°Π½Π΄ΠΈΠ½Π° Π1 Π΄Π»Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΡΠΎΠ΄ΠΎΠ²
A clinical prospective examination of 90 women with complete pregnancy and indications for labor induction because of unsatisfactory maturity of uterus cervix has been made. The aim was to create a comparative analysis of efficiency of intravaginal introduction of prostaglandin synthetic analogue E1 misoprostol (Β«SytotecΒ») and intracervical introduction of prostaglandin E2 dinoprostone (Β«PrepidilΒ» gel) for uterus cervix preparation and labor induction at complete pregnancy. Misoprostol in a dose of 25 mkg has been introduced to pregnant women of the 1 group (n=44), every 4 hours not more than 3 times. In case of discharge of waters or labor activity the second introduction has not been done. Dinoprostone has been introduced intracervically in a single dose to pregnant women of the 2 group (n=46). The use of misoprostol has been accompanied by spontaneous beginning of labor activity by 2 times more often than the use of dinoprostone. The quantity of vaginal births within 12 and 24 hours of observation has been surely greater and the duration of time between the beginning of introduction and labor has been surely smaller in the group of women received misoprostol as compared to the one received dinoprostone. It has not been revealed any differences between examined groups by the frequency of uterus hyperstimulation symptom development, labor duration, frequency of abdominal and vaginal labor, as well as perinatal outcomes.Π‘ ΡΠ΅Π»ΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΡΠ°Π²Π°Π³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³Π° ΠΏΡΠΎΡΡΠ°Π³Π»Π°Π½Π΄ΠΈΠ½Π° Π1 ΠΌΠΈΠ·ΠΎΠΏΡΠΎΡΡΠΎΠ»Π° (Β«Π‘Π°ΠΉΡΠΎΡΠ΅ΠΊΒ») ΠΈ ΠΈΠ½ΡΡΠ°ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠΎΡΡΠ°Π³Π»Π°Π½Π΄ΠΈΠ½Π° Π2 Π΄ΠΈΠ½ΠΎΠΏΡΠΎΡΡΠΎΠ½Π° (Π³Π΅Π»Ρ Β«ΠΡΠ΅ΠΏΠΈΠ΄ΠΈΠ»Β») Π΄Π»Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΈ Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΠΎΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ 90 ΠΆΠ΅Π½ΡΠΈΠ½ Ρ Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΠΎΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡΡ, ΠΈΠΌΠ΅ΡΡΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π΄Π»Ρ ΡΠΎΠ΄ΠΎΠ²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠΈ Π½Π΅ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π·ΡΠ΅Π»ΠΎΡΡΠΈ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ. ΠΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ 1-ΠΉ Π³ΡΡΠΏΠΏΡ (n = 44) ΠΈΠ½ΡΡΠ°Π²Π°Π³ΠΈΠ½Π°Π»ΡΠ½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΌΠΈΠ·ΠΎΠΏΡΠΎΡΡΠΎΠ» Π² Π΄ΠΎΠ·Π΅ 25 ΠΌΠΊΠ³ ΡΠ΅ΡΠ΅Π· ΠΊΠ°ΠΆΠ΄ΡΠ΅ 4 Ρ Π½Π΅ Π±ΠΎΠ»Π΅Π΅ 3 ΡΠ°Π·. ΠΠΎΠ²ΡΠΎΡΠ½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΡΠ»ΡΡΠ°Π΅ ΠΎΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ ΠΈΠ»ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ 2-ΠΉ Π³ΡΡΠΏΠΏΡ (n = 46) ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΈΠ½ΡΡΠ°ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π΄ΠΈΠ½ΠΎΠΏΡΠΎΡΡΠΎΠ½. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠΈΠ·ΠΎΠΏΡΠΎΡΡΠΎΠ»Π° Π² 2 ΡΠ°Π·Π° ΡΠ°ΡΠ΅ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡ ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΡΠΌ Π½Π°ΡΠ°Π»ΠΎΠΌ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΡΠ΅ΠΌ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π΄ΠΈΠ½ΠΎΠΏΡΠΎΡΡΠΎΠ½Π°. ΠΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π²Π»Π°Π³Π°Π»ΠΈΡΠ½ΡΡ
ΡΠΎΠ΄ΠΎΠ² Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 12 ΠΈ 24 Ρ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π±ΡΠ»ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π±ΠΎΠ»ΡΡΠ΅, Π° ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΎΡ Π½Π°ΡΠ°Π»Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π΄ΠΎ ΡΠΎΠ΄ΠΎΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΌΠ΅Π½ΡΡΠ΅ Π² Π³ΡΡΠΏΠΏΠ΅ ΠΆΠ΅Π½ΡΠΈΠ½, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΠΌΠΈΠ·ΠΎΠΏΡΠΎΡΡΠΎΠ», ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π΄ΠΈΠ½ΠΎΠΏΡΠΎΡΡΠΎΠ½. ΠΠ΅ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠΌΠΈ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ Π² ΡΠ°ΡΡΠΎΡΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² Π³ΠΈΠΏΠ΅ΡΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠΈ, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ², ΡΠ°ΡΡΠΎΡΠ΅ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ Π²Π»Π°Π³Π°Π»ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ΄ΠΎΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠ΅ΡΠΈΠ½Π°ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄Π°Ρ
Interferon status at the women with recurrent genital herpes in combined liposomal RNA treatment
The aim of this study was the estimation of the influence of liposomal ribonucleic acid (RNA) medicine Β«LiprinaΒ» on interferon status of women with recurrent genital herpes. In this study 60 women were included, who combined (acyclovir and Liprina, nΒ =Β 40) or monoterapy with acyclovir (nΒ =Β 20) were received. The levels of serum interferon alpha and gamma along with cervical virus elimination were estimated. The medicine Β«LiprinaΒ» increased the therapy efficiency of the women with genital herpes, that perhaps related with endogen interferon production amplification