An efficient multicomponent synthesis and <i>in vitro</i> anticancer activity of dihydropyranochromene and chromenopyrimidine-2,5-diones

<p>A series of dihydropyranochromenes and chromenopyrimidine-2,5-diones having chromene scaffold were synthesized <i>via</i> efficient multicomponent protocol in aqueous β-cyclodextrin. The reaction is free of toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly. All the synthesized compounds biologically evaluated for their potential inhibitory effect on both cervical cancer cell line (HeLa) and human breast adenocarcinoma cell line (MCF-7). Of these compounds, <b>4d</b> was found to be the most potent inhibitors of HeLa and MCF-7 demonstrating IC₅₀ values of 19 µM and 7 µM. Compounds <b>4b</b>, <b>4e</b> and <b>4f</b> also shown significantly good <i>in vitro</i> anticancer activity against HeLa and MCF-7 cancer cell lines.</p