Rotation Modulations and Distributions of the Flare Occurrence Rates on the Surface of Five UV Ceti Type Stars

In this study, we considered stellar spots, stellar flares, and also the relation between these two magnetic proccesses that take place on UV Cet stars. In addition, the hypothesis about slow flares described by Gurzadyan (1986 Ap&SS, 125, 127) was investigated. All of these discussions were based on the results of three years of observations of UV Cet-type stars: AD Leo, EV Lac, V1005 Ori, EQ Peg, and V1054 Oph. First of all, the results show that stellar spot activity occurs on the stellar surface of EV Lac, V1005 Ori, and EQ Peg, while AD Leo does not show any short-term variability and V1054 Oph does not exhibit any variability. We report on new ephemerides for EV Lac, V1005 Ori, and EQ Peg, obtained from time-series analyses. The phases, computed at intervals of 0.10 phase length, where the mean flare occurence rates to obtain maximum amplitude; also, the phases of rotational modulation were compared in order to investigate whether there is any longitudinal relation between stellar flares and spots. Although the results show that flare events are related with spotted areas on stellar surfaces during some of the observing seasons, we did not find any clear correlation among them. Finally, it was tested whether slow flares are fast flares occurring on the opposite side of the stars according to the direction of the observers, as mentioned in a hypothesis developed by <A >Gurzadyan (1986). The flare occurence rates reveal that both slow and fast flares can occur in any rotational phases. The flare occurence rates of both fast and slow flares vary in the same way along the longitudes for all program stars. These results are not expected based on the case mentioned in the hypothesis.Comment: 24 pages, 15 figures, 6 tabels, 2011PASJ...63..427

V1135 Herculis: a double-lined eclipsing binary with an Anomalous Cepheid

BVR light curves and radial velocities for the double-lined eclipsing binary V1135\,Her were obtained. The brighter component of V1135\,Her is a Cepheid variable with a pulsation period of 4.22433$\pm$0.00026 days. The orbital period of the system is about 39.99782$\pm$0.00233 days, which is the shortest value among the known Type\,II Cepheid binaries. The observed B, V, and R magnitudes were cleaned for the intrinsic variations of the primary star. The remaining light curves, consisting of eclipses and proximity effects, are obtained. Our analyses of the multi-colour light curves and radial velocities led to the determination of fundamental stellar properties of both components of the interesting system V1135\,Her. The system consists of two evolved stars, G1+K3 between giants and supergiants, with masses of M$_1$=1.461$\pm$0.054 \Msun ~and M$_2$=0.504$\pm$0.040 {\Msun} and radii of R$_1$=27.1$\pm$0.4 {\Rsun} and R$_2$=10.4$\pm$0.2 {\Rsun}. The pulsating star is almost filling its corresponding Roche lobe which indicates the possibility of mass loss or transfer having taken place. We find an average distance of d=7500$\pm$450 pc using the BVR magnitudes and also the V-band extinction. Location in the Galaxy and the distance to the galactic plane with an amount of 1300 pc indicate that it probably belongs to the thick-disk population. Most of the observed and calculated parameters of the V1135\,Her and its location on the color-magnitude and period-luminosity diagrams lead to a classification of an Anomalous Cepheid.Comment: 25 pages, 9 Tables, 9 Figures, Accepted Revista Mexicana de Astronom\'ia y Astrof\'isica. arXiv admin note: substantial text overlap with arXiv:1211.120

Analytical, numerical, and experimental investigation of a Luneburg lens system for directional cloaking

In this study, the design of a directional cloaking based on the Luneburg lens system is proposed and its operating principle is experimentally verified. The cloaking concept is analytically investigated via geometrical optics and numerically realized with the help of the finite-difference time-domain method. In order to benefit from its unique focusing and/or collimating characteristics of light, the Luneburg lens is used. We show that by the proper combination of Luneburg lenses in an array form, incident light bypasses the region between junctions of the lenses, i.e., the "dark zone." Hence, direct interaction of an object with propagating light is prevented if one places the object to be cloaked inside that dark zone. This effect is used for hiding an object which is made of a perfectly electric conductor material. In order to design an implementable cloaking device, the Luneburg lens is discretized into a photonic crystal structure having gradually varying air cylindrical holes in a dielectric material by using Maxwell Garnett effective medium approximations. Experimental verifications of the designed cloaking structure are performed at microwave frequencies of around 8 GHz. The proposed structure is fabricated by three-dimensional printing of dielectric polylactide material and a brass metallic alloy is utilized in place of the perfectly electric conductor material in microwave experiments. Good agreement between numerical and experimental results is found. © 2019 American Physical Society

The Patterns of High-Level Magnetic Activity Occurring on the Surface of V1285 Aql: The OPEA Model of Flares and DFT Models of Stellar Spots

Statistically analyzing Johnson UBVR observations of V1285 Aql during the three observing seasons, both activity level and behavior of the star are discussed in respect to obtained results. We also discuss the out-of-flare variation due to rotational modulation. Eighty-three flares were detected in the U-band observations of season 2006 . First, depending on statistical analyses using the independent samples t-test, the flares were divided into two classes as the fast and the slow flares. According to the results of the test, there is a difference of about 73 s between the flare-equivalent durations of slow and fast flares. The difference should be the difference mentioned in the theoretical models. Second, using the one-phase exponential association function, the distribution of the flare-equivalent durations versus the flare total durations was modeled. Analyzing the model, some parameters such as plateau, half-life values, mean average of the flare-equivalent durations, maximum flare rise, and total duration times are derived. The plateau value, which is an indicator of the saturation level of white-light flares, was derived as 2.421{\pm}0.058 s in this model, while half-life is computed as 201 s. Analyses showed that observed maximum value of flare total duration is 4641 s, while observed maximum flare rise time is 1817 s. According to these results, although computed energies of the flares occurring on the surface of V1285 Aql are generally lower than those of other stars, the length of its flaring loop can be higher than those of more active stars.Comment: 44 pages, 10 figures, 5 tables, 2011PASP..123..659

A New Method for Classifying Flares of UV Ceti Type Stars: Differences Between Slow and Fast Flares

In this study, a new method is presented to classify flares derived from the photoelectric photometry of UV Ceti type stars. This method is based on statistical analyses using an independent samples t-test. The data used in analyses were obtained from four flare stars observed between 2004 and 2007. The total number of flares obtained in the observations of AD Leo, EV Lac, EQ Peg, and V1054 Oph is 321 in the standard Johnson U band. As a result flares can be separated into two types, slow and fast, depending on the ratio of flare decay time to flare rise time. The ratio is below 3.5 for all slow flares, while it is above 3.5 for all fast flares. Also, according to the independent samples t-test, there is a difference of about 157 s between equivalent durations of slow and fast flares. In addition, there are significant differences between amplitudes and rise times of slow and fast flares.Comment: 46 pages, 7 figures, 4 tabels, 2010AJ....140..483

CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes

B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors. Lately, we demonstrated that lentiviral vectors pseudotyped with modified measles virus (MV) glycoproteins hemagglutinin, responsible for receptor recognition, and fusion protein were able to overcome this transduction block. They use either the natural MV receptors, CD46 and signaling lymphocyte activation molecule (SLAM), for cell entry (MV-LV) or the vector particles were further modified to selectively enter via the CD20 molecule, which is exclusively expressed on B lymphocytes (CD20-LV). It has been shown previously that transduction by MV-LV does not induce B lymphocyte activation. However, if this is also true for CD20-LV is still unknown. Here, we generated a vector specific for another B lymphocyte marker, CD19, and compared its ability to transduce resting B lymphocytes with CD20-LV. The vector (CD19ds-LV) was able to stably transduce unstimulated B lymphocytes, albeit with a reduced efficiency of about 10% compared to CD20-LV, which transduced about 30% of the cells. Since CD20 as well as CD19 are closely linked to the B lymphocyte activation pathway, we investigated if engagement of CD20 or CD19 molecules by the vector particles induces activating stimuli in resting B lymphocytes. Although, activation of B lymphocytes often involves calcium influx, we did not detect elevated calcium levels. However, the activation marker CD71 was substantially up-regulated upon CD20-LV transduction and most importantly, B lymphocytes transduced with CD20-LV or CD19ds-LV entered the G1b phase of cell cycle, whereas untransduced or MV-LV transduced B lymphocytes remained in G0. Hence, CD20 and CD19 targeting vectors induce activating stimuli in resting B lymphocytes, which most likely renders them susceptible for lentiviral vector transduction

Sleep disruption due to nocturnal heartburn: a review of the evidence and clinical implications

Nocturnal heartburn (NHB) is a symptom that affects up to 25% of the general population and has been shown to cause sleep disruption that adversely affects quality of life and psychomotor performance. Few studies have evaluated the association between occasional NHB and sleep disturbances; therefore, this connection may be underappreciated and left untreated by the primary care provider and patient, with potentially significant negative clinical consequences and effects on quality of life. This review sought to describe what is currently known about the interplay between occasional NHB and sleep disruption, and identify whether acid suppression therapy can improve symptoms of occasional NHB and associated sleep disruptions. The pathophysiology of heartburn-induced sleep disruption appears to follow a bidirectional cycle due to the normal physiologic changes that occur in the upper gastrointestinal tract during sleep and due to the potential for heartburn symptoms to cause sleep arousal. The majority of the identified studies suggested that pharmacologic interventions for acid reduction, including proton pump inhibitors or histamine type-2 receptor antagonists (H2RAs), improved objective and/or subjective sleep outcomes among individuals with gastroesophageal reflux disease (GERD) and NHB. Several studies specific to famotidine demonstrated that treatment with 10 mg or 20 mg reduced nighttime awakenings due to NHB. In conclusion, NHB symptoms can cause sleep dysfunction that can have a profound adverse downstream effect on quality of life, next-day functioning, and health-related outcomes. The current approach to managing occasional NHB is similar to that associated with GERD, highlighting the need for studies specific to the occasional heartburn population. Health care providers should investigate NHB as one of the potential causes of sleep complaints, and patients with heartburn should be questioned about sleep quality, recalled arousals, next-day vitality, early fatigue, and next-day functioning

Modelling home care organisations from an operations management perspective

Home Care (HC) service consists of providing care to patients in their homes. During the last decade, the HC service industry experienced significant growth in many European countries. This growth stems from several factors, such as governmental pressure to reduce healthcare costs, demographic changes related to population ageing, social changes, an increase in the number of patients that suffer from chronic illnesses, and the development of new home-based services and technologies. This study proposes a framework that will enable HC service providers to better understand HC operations and their management. The study identifies the main processes and decisions that relate to the field of HC operations management. Hence, an IDEF0 (Integrated Definition for Function Modelling) activity-based model describes the most relevant clinical, logistical and organisational processes associated with HC operations. A hierarchical framework for operations management decisions is also proposed. This analysis is derived from data that was collected by nine HC service providers, which are located in France and Italy, and focuses on the manner in which operations are run, as well as associated constraints, inputs and outputs. The most challenging research areas in the field of HC operations management are also discussed