Torsional Newton-Cartan Geometry and Lifshitz Holography

We obtain the Lifshitz UV completion in a specific model for z=2 Lifshitz geometries. We use a vielbein formalism which enables identification of all the sources as leading components of well-chosen bulk fields. We show that the geometry induced from the bulk onto the boundary is a novel extension of Newton-Cartan geometry with a specific torsion tensor. We explicitly compute all the vevs including the boundary stress-energy tensor and their Ward identities. After using local symmetries/Ward identities the system exhibits 6+6 sources and vevs. The FG expansion exhibits, however, an additional free function which is related to an irrelevant operator whose source has been turned off. We show that this is related to a second UV completion.Comment: v2: 5 pages, matches version published in PR

CREATIVITY IN STRATEGIC PLANNING: THE INFLUENCE OF TEMPORAL PERSPECTIVE

As organizational environments become more turbulent and complex and as uncertainty about the future increases, reliance on quantitative decision-making approaches for strategic planning becomes less appropriate. Scenario analysis can be an effective qualitative technique for enhancing strategic planning. Typically, scenarios are presented as alternate futures. Some theorists, however, have suggested that forward and backward thinking are different cognitive processes. In this study, we investigate the effect of presenting scenarios retrospectively; that is, as if future events had already happened. A repeated measures laboratory study compared the performance of professional planners (n = 64) using prospective and retrospective scenarios in two simulated business planning tasks. Measures consisted of objective factors (number of individual planning statements and number of monitoring statements), subjective factors (quality based on an 18-question rating instrument), and subject attitudes concerning their experience with the two treatments. Results suggest that use of retrospective scenarios do increase the number of planning statements. In addition, plans prepared using retrospective scenarios were rated higher overall than those prepared with prospective scenarios. Moreover, evidence emerged that a subset of subjects were better able to make use of the retrospective technique, suggesting that selection along with training may improve planning performance.Information Systems Working Papers Serie

Low Voltage Totally Free Flexible RF MEMS Switch With Anti-Stiction System

This paper concerns a new design of RF MEMS switch combined with an innovative process which enable low actuation voltage (<5V) and avoid stiction. First, the structure described with principal design issues, the corresponding anti-stiction system is presented and FEM simulations are done. Then, a short description of the process flow based on two non polymer sacrificial layers. Finally, RF measurements are presented and preliminary experimental protocol and results of anti-stiction validation is detailed. Resulting RF performances are -30dB of isolation and -0.45dB of insertion loss at 10 GHz.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

CREATIVITY IN STRATEGIC PLANNING: THE INFLUENCE OF TEMPORAL PERSPECTIVE

As organizational environments become more turbulent and complex and as uncertainty about the future increases, reliance on quantitative decision-making approaches for strategic planning becomes less appropriate. Scenario analysis can be an effective qualitative technique for enhancing strategic planning. Typically, scenarios are presented as alternate futures. Some theorists, however, have suggested that forward and backward thinking are different cognitive processes. In this study, we investigate the effect of presenting scenarios retrospectively; that is, as if future events had already happened. A repeated measures laboratory study compared the performance of professional planners (n = 64) using prospective and retrospective scenarios in two simulated business planning tasks. Measures consisted of objective factors (number of individual planning statements and number of monitoring statements), subjective factors (quality based on an 18-question rating instrument), and subject attitudes concerning their experience with the two treatments. Results suggest that use of retrospective scenarios do increase the number of planning statements. In addition, plans prepared using retrospective scenarios were rated higher overall than those prepared with prospective scenarios. Moreover, evidence emerged that a subset of subjects were better able to make use of the retrospective technique, suggesting that selection along with training may improve planning performance.Information Systems Working Papers Serie

Brown-York Energy and Radial Geodesics

We compare the Brown-York (BY) and the standard Misner-Sharp (MS) quasilocal energies for round spheres in spherically symmetric space-times from the point of view of radial geodesics. In particular, we show that the relation between the BY and MS energies is precisely analogous to that between the (relativistic) energy E of a geodesic and the effective (Newtonian) energy E_{eff} appearing in the geodesic equation, thus shedding some light on the relation between the two. Moreover, for Schwarzschild-like metrics we establish a general relationship between the BY energy and the geodesic effective potential which explains and generalises the recently observed connection between negative BY energy and the repulsive behaviour of geodesics in the Reissner-Nordstrom metric. We also comment on the extension of this connection between geodesics and the quasilocal BY energy to regions inside a horizon.Comment: v3: 7 pages, shortened and revised version to appear in CQ

The AMCIS 2003 Panels of IS Education-II: The Chicken and the Egg Debate: Positioning Database Content in the Information Systems Curriculum

This paper summarizes the results of a panel on how database content is covered in current university programs, with reference to the IS2002 model curriculum. Panelists included information systems (IS) faculty members who are actively involved in determining the coverage of database content at their institutions and in establishing academy-wide database content and technology resources. Topics included positioning database content in the overall curriculum, sequencing of content within the database course(s), and summary suggestions for tailoring database coverage at colleges and universities

Holographic Renormalization for z=2 Lifshitz Space-Times from AdS

Lifshitz space-times with critical exponent z=2 can be obtained by dimensional reduction of Schroedinger space-times with critical exponent z=0. The latter space-times are asymptotically AdS solutions of AdS gravity coupled to an axion-dilaton system and can be uplifted to solutions of type IIB supergravity. This basic observation is used to perform holographic renormalization for 4-dimensional asymptotically z=2 locally Lifshitz space-times by Scherk-Schwarz dimensional reduction of the corresponding problem of holographic renormalization for 5-dimensional asymptotically locally AdS space-times coupled to an axion-dilaton system. We can thus define and characterize a 4-dimensional asymptotically locally z=2 Lifshitz space-time in terms of 5-dimensional AdS boundary data. In this setup the 4-dimensional structure of the Fefferman-Graham expansion and the structure of the counterterm action, including the scale anomaly, will be discussed. We find that for asymptotically locally z=2 Lifshitz space-times obtained in this way there are two anomalies each with their own associated nonzero central charge. Both anomalies follow from the Scherk--Schwarz dimensional reduction of the 5-dimensional conformal anomaly of AdS gravity coupled to an axion-dilaton system. Together they make up an action that is of the Horava-Lifshitz type with nonzero potential term for z=2 conformal gravity.Comment: 32 pages, v2: modified discussion of the central charge

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

Immune responses against multiple epitopes are required for the prevention of hepatitis C virus (HCV) infection, and the progression to phase I trials of candidates may be guided by comparative immunogenicity studies in non-human primates. Four vectors, DNA, SFV, human serotype 5 adenovirus (HuAd5) and Modified Vaccinia Ankara (MVA) poxvirus, all expressing hepatitis C virus Core, E1, E2 and NS3, were combined in three prime-boost regimen, and their ability to elicit immune responses against HCV antigens in rhesus macaques was explored and compared. All combinations induced specific T-cell immune responses, including high IFN-γ production. The group immunized with the SFV+MVA regimen elicited higher E2-specific responses as compared with the two other modalities, while animals receiving HuAd5 injections elicited lower IL-4 responses as compared with those receiving MVA. The IFN-γ responses to NS3 were remarkably similar between groups. Only the adenovirus induced envelope-specific antibody responses, but these failed to show neutralizing activity. Therefore, the two novel regimens failed to induce superior responses as compared with already existing HCV vaccine candidates. Differences were found in response to envelope proteins, but the relevance of these remain uncertain given the surprisingly poor correlation with immunogenicity data in chimpanzees, underlining the difficulty to predict efficacy from immunology studies.This work was supported by European Union contract QLK2-CT-1999- 00356, by the Biomedical Primate Research Centre, The Netherlands, and by the Swedish Research Council. We are grateful to Alexander van den Berg for technical assistance with the ICS, to our colleagues from Animal Science Department for technical assistance and expert care of the macaques, to the participants of the European HCVacc Cluster who provided help and support, and to Thomas Darton (Oxford Vaccine Group, UK) for input and advice on the manuscript. Christine Rollier is an Oxford Martin fellow and a Jenner Insitute Investigator.This is the author accepted manuscript. The final version is available from Nature Publishing Group at https://doi.org/10.1038/gt.2016.55

Clearance of Genotype 1b Hepatitis C Virus in Chimpanzees in the Presence of Vaccine-Induced E1-Neutralizing Antibodies

Accumulating evidence indicates that neutralizing antibodies play an important role in protection from chronic hepatitis C virus (HCV) infection. Efforts to elicit such responses by immunization with intact heterodimeric E1E2 envelope proteins have met with limited success. To determine whether antigenic sites, which are not exposed by the combined E1E2 heterodimer structure, are capable of eliciting neutralizing antibody responses, we expressed and purified each as separate recombinant proteins E1 and E2, from which the immunodominant hypervariable region (HVR-1) was deleted. Immunization of chimpanzees with either E1 or E2 alone induced antigen-specific T-helper cytokines of similar magnitude. Unexpectedly, the capacity to neutralize HCV was observed in E1 but not in animals immunized with E2 devoid of HVR-1. Furthermore, in vivo only E1-vaccinated animals exposed to the heterologous HCV-1b inoculum cleared HCV infection