274 research outputs found

    Cosmological constant influence on cosmic string spacetime

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    We investigate the line element of spacetime around a linear cosmic string in the presence of a cosmological constant. We obtain the metric and argue that it should be discarded because of asymptotic considerations. Then a time dependent and consistent form of the metric is obtained and its properties are discussed.Comment: 3 page

    Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1ÎČ and nitric oxide on hypothala...

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    Abstract—The neuroimmune-endocrine dysfunction has been accepted as one of fundamental mechanisms contributing to the pathophysiology of psychiatric disorders including depression and anxiety. In this study, we aimed to evaluate the involvement of hypothalamic–pituitary–adre nal (HPA) axis, interleukin-1b, and nitrergic system in mediating the negative behavioral impacts of juvenile social isolation stress (SIS) in male mice. We also investigated the possible protective effects of lithium on behavioral and neurochemical changes in socially isolated animals. Results showed that experiencing 4-weeks of juvenile SIS provoked depressive and anxiety-like behaviors that were associated with hyper responsiveness of HPA axis, upregulation of interleukin-1b, and nitric oxide (NO) overproduction in the pre-frontal cortex and hippocampus. Administration of lithium (10 mg/kg) significantly attenuated the depressant and anxiogenic effects of SIS in behavioral tests. Lithium also restored the negative effects of SIS on cortical and hippocampal interleukin-1b and NO as well as HPA axis deregulation. Unlike the neutralizing effects of L-arginine (NO precursor), administration of L-NAME (3 mg/kg) and aminoguanidine (20 mg/kg) potentiated the positive effects of lithium on the behavioral and neurochemical profile of isolated mice. In conclusion, our results revealed that juvenile SIS-induced behavioral deficits are associated with abnormalities in HPA-immune function. Also, we suggest that alleviating effects of lithium on behavioral profile of isolated mice may be partly mediated by mitigating the negative impact of NO on HPA-immune function. ïżœ 2015 IBRO. Published by Elsevier Ltd. All rights reserve

    Air-water two-phase flow modeling of turbulent surf and swash zone wave motions

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    Wave breaking and wave runup/rundown have a major influence on nearshore hydrodynamics, morphodynamics and beach evolution. In the case of wave breaking, there is significant mixing of air and water at the wave crest, along with relatively high kinetic energy, so prediction of the free surface is complicated. Most hydrodynamic studies of surf and swash zone are derived from single-phase flow, in which the role of air is ignored. Two-phase flow modeling, consisting of both phases of water and air, may be a good alternative numerical modeling approach for simulating nearshore hydrodynamics and, consequently, sediment transport. A two-phase flow tool can compute more realistically the shape of the free surface, while the effects of air are accounted for. This paper used models based on two-dimensional, two-phase Reynolds-Averaged Navier-Stokes equations, the Volume-Of-Fluid surface capturing technique and different turbulence closure models, i.e., k-Δ, k-ω and Re-Normalized Group (RNG). Our numerical results were compared with the available experimental data. Comparison of the employed method with a model not utilizing a two-phase flow modeling demonstrates that including the air phase leads to improvement in simulation of wave characteristics, especially in the vicinity of the breaking point. The numerical results revealed that the RNG turbulence model yielded better predictions of nearshore zone hydrodynamics, although the k-Δ model also gave satisfactory predictions. The model provides new insights for the wave, turbulence and means flow structure in the surf and swash zones
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