94 research outputs found
Symplectically harmonic cohomology of nilmanifolds
This paper can be considered as an extension to our paper [On symplectically
harmonic forms on six-dimensional nilmanifolds, Comment. Math. Helv. 76 (2001),
n 1, 89-109]. Also, it contains a brief survey of recent results on
symplectically harmonic cohomology.Comment: 18 page
Using mixed data in the inverse scattering problem
Consider the fixed- inverse scattering problem. We show that the zeros
of the regular solution of the Schr\"odinger equation, , which are
monotonic functions of the energy, determine a unique potential when the domain
of the energy is such that the range from zero to infinity. This
suggests that the use of the mixed data of phase-shifts
, for which the zeros of the regular solution are monotonic in both domains,
and range from zero to infinity, offers the possibility of determining the
potential in a unique way.Comment: 9 pages, 2 figures. Talk given at the Conference of Inverse Quantum
Scattering Theory, Hungary, August 200
Grothendieck groups and a categorification of additive invariants
A topologically-invariant and additive homology class is mostly not a natural
transformation as it is. In this paper we discuss turning such a homology class
into a natural transformation; i.e., a "categorification" of it. In a general
categorical set-up we introduce a generalized relative Grothendieck group from
a cospan of functors of categories and also consider a categorification of
additive invariants on objects. As an example, we obtain a general theory of
characteristic homology classes of singular varieties.Comment: 27 pages, to appear in International J. Mathematic
Massey products in symplectic manifolds
The paper is devoted to study of Massey products in symplectic manifolds.
Theory of generalized and classical Massey products and a general construction
of symplectic manifolds with nontrivial Massey products of arbitrary large
order are exposed. The construction uses the symplectic blow-up and is based on
the author results, which describe conditions under which the blow-up of a
symplectic manifold X along its submanifold Y inherits nontrivial Massey
products from X ot Y. This gives a general construction of nonformal symplectic
manifolds.Comment: LaTeX, 48 pages, 2 figure
Linking and causality in globally hyperbolic spacetimes
The linking number is defined if link components are zero homologous.
Our affine linking invariant generalizes to the case of linked
submanifolds with arbitrary homology classes. We apply to the study of
causality in Lorentz manifolds. Let be a spacelike Cauchy surface in a
globally hyperbolic spacetime . The spherical cotangent bundle
is identified with the space of all null geodesics in
Hence the set of null geodesics passing through a point gives an
embedded -sphere in called the sky of Low observed
that if the link is nontrivial, then are causally
related. This motivated the problem (communicated by Penrose) on the Arnold's
1998 problem list to apply link theory to the study of causality. The spheres
are isotopic to fibers of They are nonzero
homologous and is undefined when is closed, while is well defined. Moreover, if is not an
odd-dimensional rational homology sphere. We give a formula for the increment
of \alk under passages through Arnold dangerous tangencies. If is
such that takes values in and is conformal to having all
the timelike sectional curvatures nonnegative, then are causally
related if and only if . We show that in
nonrefocussing are causally unrelated iff can be deformed
to a pair of -fibers of by an isotopy through skies. Low
showed that if (\ss, g) is refocussing, then is compact. We show that the
universal cover of is also compact.Comment: We added: Theorem 11.5 saying that a Cauchy surface in a refocussing
space time has finite pi_1; changed Theorem 7.5 to be in terms of conformal
classes of Lorentz metrics and did a few more changes. 45 pages, 3 figures. A
part of the paper (several results of sections 4,5,6,9,10) is an extension
and development of our work math.GT/0207219 in the context of Lorentzian
geometry. The results of sections 7,8,11,12 and Appendix B are ne
Exotic smooth structures and symplectic forms on closed manifolds
We give a short proof of the (known) result that there are no Kaehler
structures on exotic tori. This yields a negative solution to a problem posed
by Benson and Gordon. W discuss the symplectic version of the problem and
analyze results which yield an evidence for the conjecture that there are no
symplectic structures on exotic tori.Comment: AMSLaTeX, 16 pages, a new version. A survey of the symplectic version
of the problem is adde
Hysteresis, Avalanches, and Disorder Induced Critical Scaling: A Renormalization Group Approach
We study the zero temperature random field Ising model as a model for noise
and avalanches in hysteretic systems. Tuning the amount of disorder in the
system, we find an ordinary critical point with avalanches on all length
scales. Using a mapping to the pure Ising model, we Borel sum the
expansion to for the correlation length exponent. We sketch a
new method for directly calculating avalanche exponents, which we perform to
. Numerical exponents in 3, 4, and 5 dimensions are in good
agreement with the analytical predictions.Comment: 134 pages in REVTEX, plus 21 figures. The first two figures can be
obtained from the references quoted in their respective figure captions, the
remaining 19 figures are supplied separately in uuencoded forma
Intrinsic Thermal Sensing Controls Proteolysis of Yersinia Virulence Regulator RovA
Pathogens, which alternate between environmental reservoirs and a mammalian host, frequently use thermal sensing devices to adjust virulence gene expression. Here, we identify the Yersinia virulence regulator RovA as a protein thermometer. Thermal shifts encountered upon host entry lead to a reversible conformational change of the autoactivator, which reduces its DNA-binding functions and renders it more susceptible for proteolysis. Cooperative binding of RovA to its target promoters is significantly reduced at 37°C, indicating that temperature control of rovA transcription is primarily based on the autoregulatory loop. Thermally induced reduction of DNA-binding is accompanied by an enhanced degradation of RovA, primarily by the Lon protease. This process is also subject to growth phase control. Studies with modified/chimeric RovA proteins indicate that amino acid residues in the vicinity of the central DNA-binding domain are important for proteolytic susceptibility. Our results establish RovA as an intrinsic temperature-sensing protein in which thermally induced conformational changes interfere with DNA-binding capacity, and secondarily render RovA susceptible to proteolytic degradation
Characterization techniques for studying the properties of nanocarriers for systemic delivery
Nanocarriers have attracted a huge interest in the last decade as efficient drug delivery systems and diagnostic tools. They enable effective, targeted, controlled delivery of therapeutic molecules while lowering the side effects caused during the treatment. The physicochemical properties of nanoparticles determine their in vivo pharmacokinetics, biodistribution and tolerability. The most analyzed among these physicochemical properties are shape, size, surface charge and porosity and several techniques have been used to characterize these specific properties. These different techniques assess the particles under varying conditions, such as physical state, solvents etc. and as such probe, in addition to the particles themselves, artifacts due to sample preparation or environment during measurement. Here, we discuss the different methods to precisely evaluate these properties, including their advantages or disadvantages. In several cases, there are physical properties that can be evaluated by more than one technique. Different strengths and limitations of each technique complicate the choice of the most suitable method, while often a combinatorial characterization approach is needed
- …