Numerical modeling of a flexural displacement-converter mechanism to excite a flat acoustic source driven by piezoelectric stack actuators

This paper studies an acoustic source with a relatively small thickness and high bending stiffness. The acoustic source operates in the low frequency, quasi-static regime. The focus of the current study is on the actuation part in order to design an appropriate excitation mechanism. A flexural mechanism is modeled in combination with piezoelectric actuators to convert an in-plane displacement of the actuators to a perpendicular out-of-plane direction. First, an optimization simulation is used to determine the size of the required piezoelectric actuator. Then an equivalent electrical circuit of the lumped acoustic source is developed. This equivalent circuit can directly be connected to the electrical model of a switching amplifier. Finally, a coupled numerical finite element analysis is carried out by using COMSOL Multiphysics software package to model the combination of both flexural mechanism and piezoelectric device. The suggested flexural mechanism is sufficiently narrow to overcome the space limitation challenge in the design

Active control of a lumped acoustic source driven by various actuators

This paper studies an acoustic source with a relatively small thickness and high bending stiffness. The high bending stiffness is obtained with a sandwich structure in which the face of the sandwich structure internal to the source is perforated to increase the acoustic compliance. Multiple actuators are used to drive the moving component of the acoustic source. Feedback and feedforward damping control techniques are used to actively obtain a smooth frequency response, especially at low frequencies. Such a compensation scheme generally leads to amplification of the lower frequencies and may result in a significant electrical input power. In addition, a part of the input power is stored in mechanical and acoustical elements of the acoustic source. Voice coil and piezoelectric actuators are compared regarding the ability to recover the stored energy. Piezoelectric actuators are particularly attractive from energy recovery point of view because the acoustic source has to operate in the low frequency, quasi-static regime. The two-way energy ?ow between the actuator and a connected ampli?er is investigated. In particular, the effectiveness of energy recovery from the reactive components of the acoustic source is evaluated to improve the overall radiation ef?ciency. A lumped model is used to represent the acoustic source that is excited by a stacked piezoelectric element. The required power supply and resulting radiation ef?ciency are evaluated when a conventional analogue ampli?er is used. The result is compared to the case in which some parts of the stored power are recovered and sent back to the connected switching amplifier. It was found that approximately 66% of the reactive power stored in the acoustic source can be recovered. The study also reveals a significant increase in overall system ef?ciency and more than 80% decrease in the amount of required input power through recovering the reactive power in the system

Implementation issues of a high-speed distributed multi-channel ADDA system

ABSTRACT A multi-channel ADDA controller is used in many active noise cancellation and active vibration control problems. Such a controller is able to yield good performance, however it also requires a lot of hardware on a centralized place and a lot of sensitive wiring. A practical work around for this problem would be to use a local single channel controller. However such a controller would reduce the overall system performance and may introduce instability. In this paper a system will be presented that acts as a hybrid form and combines the performance of a local feedback loop with a large multi-channel controller. To reduce the wiring and the influence of disturbances on this wiring a local analog to digital and digital to analog converter will be used. These systems will be interconnected using a high-speed serial communication system. To reduce the sample rate for the overall system, a local decimation and interpolation filter will be implemented. Further performance improvements will be realized by means of a simple local feedback system. The implementation issues concerning such a system are the subject of this paper

Observations on comatose survivors of cardiopulmonary resuscitation with generalized myoclonus

BACKGROUND: There is only limited data on improvements of critical medical care is resulting in a better outcome of comatose survivors of cardiopulmonary resuscitation (CPR) with generalized myoclonus. There is also a paucity of data on the temporal dynamics of electroenephalographic (EEG) abnormalities in these patients. METHODS: Serial EEG examinations were done in 50 comatose survivors of CPR with generalized myoclonus seen over an 8 years period. RESULTS: Generalized myoclonus occurred within 24 hours after CPR. It was associated with burst-suppression EEG (n = 42), continuous generalized epileptiform discharges (n = 5), alpha-coma-EEG (n = 52), and low amplitude (10 μV <) recording (n = 1). Except in 3 patients, these EEG-patterns were followed by another of these always nonreactive patterns within one day, mainly alpha-coma-EEG (n = 10) and continuous generalized epileptiform discharges (n = 9). Serial recordings disclosed a variety of EEG-sequences composed of these EEG-patterns, finally leading to isoelectric or flat recordings. Forty-five patients died within 2 weeks, 5 patients survived and remained in a permanent vegetative state. CONCLUSION: Generalized myoclonus in comatose survivors of CPR still implies a poor outcome despite advances in critical care medicine. Anticonvulsive drugs are usually ineffective. All postanoxic EEG-patterns are transient and followed by a variety of EEG sequences composed of different EEG patterns, each of which is recognized as an unfavourable sign. Different EEG-patterns in anoxic encephalopathy may reflect different forms of neocortical dysfunction, which occur at different stages of a dynamic process finally leading to severe neuronal loss

A Meta-Analysis of the Existing Knowledge of Immunoreactivity against Hepatitis C Virus (HCV)

Approximately 3% of the world population is infected by HCV, which represents a major global health challenge. Almost 400 different scientific reports present immunological data related to T cell and antibody epitopes derived from HCV literature. Analysis of all HCV-related epitope hosted in the Immune Epitope Database (IEDB), a repository of freely accessible immune epitope data, revealed more than 1500 and 1900 distinct T cell and antibody epitopes, respectively. The inventory of all data revealed specific trends in terms of the host and the HCV genotypes from which sequences were derived. Upon further analysis we found that this large number of epitopes reflects overlapping structures, and homologous sequences derived from different HCV isolates. To access and visualize this information we developed a novel strategy that assembles large sets of epitope data, maps them onto reference genomes and displays the frequency of positive responses. Compilation of the HCV immune reactivity from hundreds of different studies, revealed a complex and thorough picture of HCV immune epitope data to date. The results pinpoint areas of more intense reactivity or research activities at the level of antibody, CD4 and CD8 responses for each of the individual HCV proteins. In general, the areas targeted by the different effector immune functions were distinct and antibody reactivity was positively correlated with hydrophilicity, while T cell reactivity correlated with hydrophobicity. At the sequence level, epitopes frequently recognized by both T cell and B cell correlated with low variability, and our analysis thus highlighted areas of potential interest for practical applications. The human reactivity was further analyzed to pinpoint differential patterns of reactivity associated with acute versus chronic infection, to reveal the apparent impact of glycosylation on T cell, but not antibody responses, and to highlight a paucity of studies involved antibody epitopes associated with virus neutralization

Fatal Cases of Influenza A(H3N2) in Children: Insights from Whole Genome Sequence Analysis

During the Northern Hemisphere winter of 2003–2004 the emergence of a novel influenza antigenic variant, A/Fujian/411/2002-like(H3N2), was associated with an unusually high number of fatalities in children. Seventeen fatal cases in the UK were laboratory confirmed for Fujian/411-like viruses. To look for phylogenetic patterns and genetic markers that might be associated with increased virulence, sequencing and phylogenetic analysis of the whole genomes of 63 viruses isolated from fatal cases and non fatal “control” cases was undertaken. The analysis revealed the circulation of two main genetic groups, I and II, both of which contained viruses from fatal cases. No associated amino acid substitutions could be linked with an exclusive or higher occurrence in fatal cases. The Fujian/411-like viruses in genetic groups I and II completely displaced other A(H3N2) viruses, but they disappeared after 2004. This study shows that two A(H3N2) virus genotypes circulated exclusively during the winter of 2003–2004 in the UK and caused an unusually high number of deaths in children. Host factors related to immune state and differences in genetic background between patients may also play important roles in determining the outcome of an influenza infection