Prevalence of Hepatitis B virus, Hepatitis C virus and human immunodeficiency virus infections among patients candidate for orthopedic trauma surgeries

Background: Infectious diseases are major public health problems, among which blood-borne ones are the most important infections. Patients who undergo orthopedic surgery are at higher risk of transmitting infectious diseases from and to others, due to repeated blood examinations and injection, drains secretion and receiving blood products. Accordingly, in this study we determined prevalence of Hepatitis B Virus (HBV) Hepatitis C Virus (HCV) and human immunodeficiency Virus (HIV) infections in patients who underwent surgery in a general training hospital. Methods: In this cross-sectional study the prevalence of HBV, HCV, and HIV infections was determined among 320 patients under orthopedic trauma surgeries in a general training hospital in Tehran, Iran from 2009 to 2011. Associations of these rates with age, gender, marital status, residence location, substance abuse history, hospital admission history, previous surgery, blood transfusion, dentistry procedures, and previous medical history were also assessed. Results: A total of 320 patients (290 male, 30 female) were studied. Ten patients (3.2) had at least one of these three infections. Totally 10 patients (3.2), 2 subjects (0.6), and 8 patients (2.5) had HCV, HIV, and HBV infections, respectively. None of the evaluated variables had significant relationship with HCV, HBV, and HIV infections (p > 0.05). Conclusion: According to the obtained results, routine use of diagnostic tests for infectious disease such as HIV and viral hepatitis is recommended and should be considered before orthopedic operations

Risk of superior gluteal nerve injury after using ante-grade femoral nailing

Antegrade intramedullary femoral nailing (AIFN) is used as the preferred treatment for diaphyseal and subtrochanteric femur fractures. Nevertheless, clinically important complications associated with obtaining nail entry including loss of hip abductor strength, chronic hip pain, heterotopic ossification and femoral head osteonecrosis have been previously shown.This study was aimed to evaluate the risk of injury to the superior gluteal nerve when Ante-grade femoral nailing is used for insertion. In current study, 25 patients with femoral shaft fractures were included in this study that 21 were male with an average age of 25.40 years, Also 4 cases were female with an average age of 28.20 years. The patients were between the ages of 93 to 05 years. EMG-MCV was taken from all patients and were reported by neurologist. Plain radiographs were taken from all patients. Pain intensity of patients in the last month were identified from 4 to 944 according to the patients statements. The frequency of patients with subjective lameness separately with or no signs was determined. In terms of the pain score, its average among all patients was calculated to be 4.92, while the average of 4.75 among men was calculated. Among women, the average was 5.60. All patients had a mean duration of 3.64 months for using crutches, that the average duration of 3.80 months for men and 3 months for women were calculated.In terms of subjective limping, 15 patients (60) complained from limping, while 10 people were not affected (40 ), of which, 12 patients (80) was belonged to men group and 3 patients (20) were assigned in women group. 5 patients were diagnosed with atrophy of gluteus medius and gluteus minimus muscles that, 3 patients were male (60) and 2 cases (40) were women respectively. EMG-NCV indicated that the Superior gluteal nerve injury had occurred in 2 patients (8) and myogenic damage of gluteus medius and gluteus minimus muscles in 5 patients (20). Our study indicated that the superior gluteal nerve injury had occurred in 2 8 of patients and myogenic damage of gluteus medius and gluteus minimus muscles in 20

Evaluation of Patellar Position before and After Medial Opening Wedge High Tibial Osteotomy: Radiographic and Computed Tomography Findings

INTRODUCTION: Genovarum is a common orthopedic problem. Its optimal prompt treatment is an issue of importance. AIM: This study was conducted to determine the radiographic changes in patella bone before and after open wedge high tibial osteotomy. MATERIAL AND METHODS: In this quasi-experimental study, 43 patients were enrolled and underwent open wedge high tibial osteotomy and the radiographic and CT-scan indices including Q-Angle, Congruence Angle, Insall-Salvati index, and TTTG were measured and compared before and after surgery. RESULTS: The result revealed that all indices including Q-Angle, Congruence Angle, Insull-Salvati index, and TTTG were not significantly differed across the study (P > 0.05). There was no difference between DLFA values before and after the operation (P> 0.05), while MPTA values were significantly different before and after operation (p <0.001). CONCLUSIONS: Totally it may be concluded that imaging indices are not differed after open wedge high tibial osteotomy and monitoring for them is not necessary and they would have no prognostic role

MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted. © 2020 The Author(s)

Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures

Introduction: It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods: This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. The patients were randomly divided into two groups using the method of block randomization including early surgery (within 24 h) and delayed surgery (after 48 h). Serum levels of inflammatory markers in both groups including interleukin (IL)-1, 5, 6, tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ) were determined using specific kits. From each patient 10 ml blood was collected for cytokine assay in their serum. Results: Our findings suggest that serum levels of IL-8 were markedly decreased from 12 h until 48 h postoperatively (p < 0.05). Moreover, the results indicated that serum levels of TNF-α were significantly increased in the early hours, but after 48 h a decreasing trend was detected (p < 0.05). Furthermore, serum levels of IL-10, IFN-γ, and IL-6 were significantly increased from 12 h until 48 h postoperatively (p < 0.05). Conclusions: The inflammatory status of the patient may be a useful adjunct in clinical decisions. With an improved understanding of the molecular basis of the inflammatory response, and by identifying relevant clinical markers of inflammation, surgeons can better manage the timing of surgical stabilization. © 2016 Termedia & Banach

Validation of initial serum creatinine as a predictive factor for development of end stage renal disease in posterior urethral valves

Objective. The aim of this study was to determine the value of initial serum creatinine in prediction of End-stage renal disease (ESRD) in children with posterior urethral valves PUV. Methods. In this retrospective study, patients diagnosed with PUV admitted in Aliasghar Children's Hospital in Tehran, Iran from 1991 through 2001 were studied. Based on the development of ESRD (need for dialysis) they were classified in two groups and their demographics, initial presentations, laboratory data, imaging findings and outcomes were reviewed and compared. Results. Thirty six male patients with PUV, treated with valve ablation (13), vesicostomy (13), or high ureterostomy (10) were followed for developing ESRD. Sixteen of the 36 patients developed ESRD at their last follow-up. There was no significant difference in age at initial presentation, presence of urinary tract infections, incidence of vesicoureteral reflux, renal dysplasia or type of primary surgical intervention between the patients with or without ESRD. Patients who progressed to ESRD had serum creatinine concentration > 1.0 mg/dl at diagnosis as compared to those without ESRD (P = 0.001). Conclusion. Initial serum creatinine is a valuable factor for prediction of renal outcome in patients with PUV. © 2008 Dr. K C Chaudhuri Foundation

Chronic Kidney Disease in Iran: First Report of the National Registry in Children and Adolescences

Purpose: Knowing the epidemiological aspects of chronic kidney disease (CKD) in children is crucial for early recognition, identification of reversible causes, and prognosis. Here, we report the epidemiological characteristics of childhood CKD in Iran. Materials and Methods: This cross-sectional study was conducted during 1991 � 2009. The data were collected using the information in the Iranian Pediatric Registry of Chronic Kidney Disease (IPRCKD) core dataset. Results: A total of 1247 children were registered. The mean age of the children at registration was 0.69 ± 4.72 years (range, 0.25 �18 years), 7.79 ± 3.18 years for hemodialysis (HD), 4.24 ± 1.86 years for continuous ambulatory peritoneal dialysis (CAPD), and 3.4±1.95 years for the children who underwent the renal transplantation (RT) (P < .001). The mean year of follow-up was 7.19 ± 4.65 years. The mean annual incidence of CKD 2�5 stages was 3.34 per million age-related population (pmarp). The mean prevalence of CKD 2�5 stages was 21.95 (pmarp). The cumulative 1-, 5-, and 10-year patients� survival rates were 98.3, 90.7, and 84.8, respectively. The etiology of the CKD included the congenital anomalies of the kidney and urinary tract (CAKUT) (40.01), glomerulopathy (19.00), unknown cause (18.28), and cystic/hereditary/congenital disease (11.14). Conclusion: The incidence and prevalence rate of pediatric CKD in Iran is relatively lower than those reported in Europe and other similar studies. CAKUT was the main cause of the CKD. Appropriate management of CAKUT including early urological intervention is required to preserve the renal function. Herein, the long-term survival rate was higher among the children with CKD than the literature. © 2021. All Rights Reserved