Время реакции в ответ на эмоциональные стимулы (включая фотопортреты с различной мимикой) в ходе фМРТ-исследования лиц с легкой и умеренной депрессией, дистимией

Objective. Estimation of the response time and accuracy of emotional stimuli during the fMRI task fulfillment in participants suffering from mild to moderate depressive disorder or from dysthymic disorder.Materials and methods. 21 subjects with mild to moderate depressive disorder or dysthymic disorder (D) participated, and 21 healthy volunteers (H) matched by age and sex ratio were included in the control group.  In two fMRI paradigms subjects were observing photos of the faces with different emotional expressions. The first task was to guess the gender of the people on the screen, and the second one was to recognize the emotion experienced by the person in the photo. In the third paradigm participants were sorting different images into pleasant and unpleasant. The subjects responded by pressing one of two buttons. The response time and accuracy were the subjects of analysis.Results. On the most of the computed parameters patients with depressive disorder did not differ from controls. However, in the first paradigm these subjects demonstrated slower reaction to neutral (H = (1415 ± 408) ms,  D = (1 878 ± 850) ms; t = 2.25; p < 0,05) and disgusted (H = (1 183 ± 310) ms, D = (1 526 ± 646) ms; t = 2.20; p < 0.05) expressions, and greater standard deviations of the response time to disgusted (H = (219 ± 125) ms,  D = (675 ± 645) ms; t = 3.18; p < 0,01), happy (H = (445 ± 310) ms, D = (836 ± 579) ms; t = 2.73;  p < 0.05), surprised (H = (580 ± 438) ms, D = (1 043 ± 785) ms; t = 2.36; p < 0,05), and neutral  (H = (487 ± 416) ms, D = (895 ± 727) ms; t = 2.23; p < 0.05) faces. On the second stage group of participants with depressive disorder had greater standard deviation of the response time to disgusted portraits (H = (1 506 ± 1 273) ms, D = (2 168 ± 1 355) ms; U =131; p < 0.05). Moreover, subjects diagnosed with a depressive disorder less often chose the answer “happy” (H = (6,8 ± 1,1) ms, D = (6.0 ± 0.8) ms; U = 131; p < 0.05) while guessing the emotion in the photo.Conclusion. Participants diagnosed with mild to moderate depressive disorder or dysthymic disorder perform significantly slower than healthy ones during the “background” processing of the facial expressions and also tend to identify mimic as happy less often than controls while aiming to recognize the feelings of others. However, the role of these features in the progress of depressive disorders and their perspectives as diagnostic markers are subjects for further research.Цель исследования – оценить время и содержание реакций на эмоциональные стимулы в процессе фМРТ-исследования у лиц с легким или умеренным депрессивным эпизодом или дистимией.Материалы и методы. В исследовании приняли участие группа (21 человек) с диагностированным легким или умеренным депрессивным эпизодом или дистимией (Д) и контрольная группа (21 волонтер) (З), идентичных по полу и возрасту. В двух задачах испытуемые, находясь внутри магнитно-резонансного томографа, воспринимали изображения лиц с различной эмоциональной мимикой. В первой пробе от участников требовалось определить пол людей на портретах, во второй – переживаемые ими эмоции. В третьей задаче предъявлялись изображения, которые нужно было разделить на нравящиеся и не нравящиеся. Ответ давался нажатием одной из двух кнопок. Оценивались время реакции и содержание ответов.Результаты. По большинству рассчитанных параметров лица с депрессивным эпизодом не отличались от условно здоровых людей. Тем не менее в первой задаче эти испытуемые характеризовались более медленной реакцией на лица с нейтральной мимикой (З = (1 415 ± 408) мс, Д = (1 878 ± 850) мс; t = 2,25; p < 0,05) и выражением отвращения (З = (1 183 ± 310) мс, Д = (1 526 ± 646) мс; t = 2,20; p < 0,05) и большим стандартным отклонением времени реакции на черты отвращения (З = (219 ± 125) мс, Д = (675 ± 645) мс; t = 3,18; p < 0,01), радости (З = (445 ± 310) мс, Д = (836 ± 579) мс; t = 2,73; p < 0,05), удивления (З = (580 ± 438) мс, Д = (1 043 ± 785) мс; t = 2,36; p < 0,05), а также на нейтральные портреты (З = (487 ± 416) мс, Д = (895 ± 727) мс; t = 2,23; p < 0,05). Во второй задаче в группе лиц с депрессивным эпизодом большим было стандартное отклонение времени реакции для лиц с брезгливой мимикой (З = (1 506 ± 1 273) мс, Д = (2 168 ± 1 355) мс; U = 131; p < 0,05). Кроме того, эти участники несколько реже выбирали ответ «радость» для характеристики мимики лиц (З = (6,8 ± 1,1) мс, Д = (6,0 ± 0,8) мс; U = 131; p < 0,05).Заключение. Показаны достоверное замедление реакций лиц с легким и умеренным депрессивным эпизодом в контексте «фоновой» обработки эмоциональной экспрессии и их тенденция реже определять мимику как радостную при целенаправленном распознавании чувств других людей. Однако изучение роли этих особенностей в развитии депрессивных расстройств и как диагностических маркеров требует дальнейших исследований

The response time to emotional stimuli (including facial expressions photos) during the fMRI scanning in affective disorders: mild and moderate depression and dysthymic disorder

Objective. Estimation of the response time and accuracy of emotional stimuli during the fMRI task fulfillment in participants suffering from mild to moderate depressive disorder or from dysthymic disorder.Materials and methods. 21 subjects with mild to moderate depressive disorder or dysthymic disorder (D) participated, and 21 healthy volunteers (H) matched by age and sex ratio were included in the control group.  In two fMRI paradigms subjects were observing photos of the faces with different emotional expressions. The first task was to guess the gender of the people on the screen, and the second one was to recognize the emotion experienced by the person in the photo. In the third paradigm participants were sorting different images into pleasant and unpleasant. The subjects responded by pressing one of two buttons. The response time and accuracy were the subjects of analysis.Results. On the most of the computed parameters patients with depressive disorder did not differ from controls. However, in the first paradigm these subjects demonstrated slower reaction to neutral (H = (1415 ± 408) ms,  D = (1 878 ± 850) ms; t = 2.25; p < 0,05) and disgusted (H = (1 183 ± 310) ms, D = (1 526 ± 646) ms; t = 2.20; p < 0.05) expressions, and greater standard deviations of the response time to disgusted (H = (219 ± 125) ms,  D = (675 ± 645) ms; t = 3.18; p < 0,01), happy (H = (445 ± 310) ms, D = (836 ± 579) ms; t = 2.73;  p < 0.05), surprised (H = (580 ± 438) ms, D = (1 043 ± 785) ms; t = 2.36; p < 0,05), and neutral  (H = (487 ± 416) ms, D = (895 ± 727) ms; t = 2.23; p < 0.05) faces. On the second stage group of participants with depressive disorder had greater standard deviation of the response time to disgusted portraits (H = (1 506 ± 1 273) ms, D = (2 168 ± 1 355) ms; U =131; p < 0.05). Moreover, subjects diagnosed with a depressive disorder less often chose the answer “happy” (H = (6,8 ± 1,1) ms, D = (6.0 ± 0.8) ms; U = 131; p < 0.05) while guessing the emotion in the photo.Conclusion. Participants diagnosed with mild to moderate depressive disorder or dysthymic disorder perform significantly slower than healthy ones during the “background” processing of the facial expressions and also tend to identify mimic as happy less often than controls while aiming to recognize the feelings of others. However, the role of these features in the progress of depressive disorders and their perspectives as diagnostic markers are subjects for further research