3,051 research outputs found
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Experimental determination of layer cloud edge charging from cosmic ray ionisation
The cloud-air transition zone at stratiform cloud edges is an electrically active region where droplet charging has been predicted. Cloud edge droplet charging is expected from vertical flow of cosmic ray generated atmospheric ions in the global electric circuit. Experimental confirmation of stratiform cloud edge electrification is presented here, through charge and droplet measurements made within an extensive layer of supercooled stratiform cloud, using a specially designed electrostatic sensor. Negative space charge up to 35 pC m−3 was found in a thin (<100 m) layer at the lower cloud boundary associated with the clear air-cloud conductivity gradient, agreeing closely with space charge predicted from the measured droplet concentration using ion-aerosol theory. Such charge levels carried by droplets are sufficient to influence collision processes between cloud droplets
AIDS Surveillance in Africa
Surveillance of the AIDS pandemic in Africa has always posed
formidable problems for epidemiologists. Diagnostic
accuracy-according to the case definitions for AIDS used in
industrialised countries-is impossible to achieve in all but a
few places with the right diagnostic facilities. Responding to
the urgent need for surveillance, the World Health Organisation
drew up a clinical case definition (the WHO/Bangui
definition), which depended on clinical criteria without the
need for serological verification.'2
Judged by its use, the WHO/Bangui definition has been
successful-52 African countries have reported cases ofAIDS
using mainly this definition.3 Some countries have modified it
to fit local circumstances, removing a defining symptom here,
adding the need for an extra sign there, and many now accept
or encourage a positive result of an HIV test as supportive
evidence. (At least one, COte d'Ivoire, requires such a result.2)
Inevitably the definition has its limitations, and two papers
in this week's journal discuss these at length (p 11852, p 11894).
Because of limited laboratory facilities published evaluations
of the WHO/Bangui definition have been mainly restricted to
groups of sick patients using HIV positivity as the reference
standard. The definition's sensitivity and specificity have
been calculated as being between 60% and 90%2 5- useful for
purposes of surveillance, but leaving uncertainty over
whether this surveillance tool is intended to monitor trends in
cases of AIDS or HIV infection. Other problems exist with
the WHO/Bangui definition. Because many doctors lack
diagnostic facilities they use the definition for diagnosis. The
title "clinical case definition" encourages this confusion. The
misuse is disturbing as the probability that a patient who
fulfils the WHO/Bangui definition tests positive for HIV may
fall well below 50% when seroprevalence is low.5
Another problem of using the definition is the delayed and
incomplete picture that it gives of the spread of infection.6 Far
preferable for surveillance of infection is the unlinked
anonymous testing for HIV of sentinel groups attending
health services67 (such as pregnant women and people with
sexually transmitted diseases), which has now begun in
several African countries89 using the same methods as in
industrialised countries.'°
Where does this leave the WHO/Bangui definition? De
Cock and colleagues rehearse the overwhelming case for
AIDS reporting to continue and suggest a thoughtful redesign
of the definition, which includes the requirement for a
positive HIV test result.3 Insisting on positive test results in all
circumstances, however, is impractical: HIV tests are already
limited and are lioely to become more so as AIDS funding to
Africa inevitably falls. As a provisional solution to the problem of surveillance the WHO/Bangui definition has been
useful, but the time has come for its reappraisal
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Observations of Saharan dust layer electrification
Electrification of atmospheric dust influences the coagulation, wet removal and fall speeds of dust particles. Alignment of dust particles can also occur in fair weather atmospheric electrical conditions if the particles are charged. However, very few electrical measurements made in elevated dust layers exist. Balloon-borne charge and particle instrumentation have been used to investigate the electrical properties of elevated Saharan dust layers. Soundings from the Cape Verde Islands, which experience frequent Saharan dust outbreaks, intercepted several dust layers. Two balloon soundings during summer 2009 detected dust particles in layers up to 4 km altitude. Simultaneous electrical measurements showed charge inside the dust layers, with a maximum measured charge density of 25 pC m − 3, sufficient to influence wet removal processes
Electrical charging of ash in Icelandic volcanic plumes
The existence of volcanic lightning and alteration of the atmospheric
potential gradient in the vicinity of near-vent volcanic plumes provides strong
evidence for the charging of volcanic ash. More subtle electrical effects are
also visible in balloon soundings of distal volcanic plumes. Near the vent,
some proposed charging mechanisms are fractoemission, triboelectrification, and
the so-called "dirty thunderstorm" mechanism, which is where ash and convective
clouds interact electrically to enhance charging. Distant from the vent, a
self-charging mechanism, probably triboelectrification, has been suggested to
explain the sustained low levels of charge observed on a distal plume. Recent
research by Houghton et al. (2013) linked the self-charging of volcanic ash to
the properties of the particle size distribution, observing that a highly
polydisperse ash distribution would charge more effectively than a monodisperse
one. Natural radioactivity in some volcanic ash could also contribute to
self-charging of volcanic plumes. Here we present laboratory measurements of
particle size distributions, triboelectrification and radioactivity in ash
samples from the Gr\'{i}msv\"{o}tn and Eyjafjallaj\"{o}kull volcanic eruptions
in 2011 and 2010 respectively, and discuss the implications of our findings.Comment: XV Conference on Atmospheric Electricity, 15-20 June 2014, Norman,
Oklahoma, US
Testing the Hubble Law with the IRAS 1.2 Jy Redshift Survey
We test and reject the claim of Segal et al. (1993) that the correlation of
redshifts and flux densities in a complete sample of IRAS galaxies favors a
quadratic redshift-distance relation over the linear Hubble law. This is done,
in effect, by treating the entire galaxy luminosity function as derived from
the 60 micron 1.2 Jy IRAS redshift survey of Fisher et al. (1995) as a distance
indicator; equivalently, we compare the flux density distribution of galaxies
as a function of redshift with predictions under different redshift-distance
cosmologies, under the assumption of a universal luminosity function. This
method does not assume a uniform distribution of galaxies in space. We find
that this test has rather weak discriminatory power, as argued by Petrosian
(1993), and the differences between models are not as stark as one might expect
a priori. Even so, we find that the Hubble law is indeed more strongly
supported by the analysis than is the quadratic redshift-distance relation. We
identify a bias in the the Segal et al. determination of the luminosity
function, which could lead one to mistakenly favor the quadratic
redshift-distance law. We also present several complementary analyses of the
density field of the sample; the galaxy density field is found to be close to
homogeneous on large scales if the Hubble law is assumed, while this is not the
case with the quadratic redshift-distance relation.Comment: 27 pages Latex (w/figures), ApJ, in press. Uses AAS macros,
postscript also available at
http://www.astro.princeton.edu/~library/preprints/pop682.ps.g
Rapid Bidirectional Switching of Synaptic NMDA Receptors
SummarySynaptic NMDA-type glutamate receptors (NMDARs) play important roles in synaptic plasticity, brain development, and pathology. In the last few years, the view of NMDARs as relatively fixed components of the postsynaptic density has changed. A number of studies have now shown that both the number of receptors and their subunit compositions can be altered. During development, the synaptic NMDARs subunit composition changes, switching from predominance of NR2B-containing to NR2A-containing receptors, but little is known about the mechanisms involved in this developmental process. Here, we report that, depending on the pattern of NMDAR activation, the subunit composition of synaptic NMDARs is under extremely rapid, bidirectional control at neonatal synapses. This switching, which is at least as rapid as that seen with AMPARs, will have immediate and dramatic consequences on the integrative capacity of the synapse
Bell-inequality violation with a triggered photon-pair source
Here we demonstrate, for the first time, violation of Bell's inequality using
a triggered quantum dot photon-pair source without post-selection. Furthermore,
the fidelity to the expected Bell state can be increased above 90% using
temporal gating to reject photons emitted at times when collection of
uncorrelated light is more probable. A direct measurement of a CHSH Bell
inequality is made showing a clear violation, highlighting that a quantum dot
entangled photon source is suitable for communication exploiting non-local
quantum correlations.Comment: 14 pages, 4 figure
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