Resource-saving technologies of railway transportation of grain freights for export

The research objective is to increase the efficiency of export railway transportation of grain freights in Ukraine by the introduction of consignor routing, a concentration of loading of grain on junction elevators and the organization of the movement of grain routes according to the schedule. According to the researchers in USA and EU, one of the effective directions for decreasing the expenses in a logistic chain of grain delivery to ports is consignor routing of railway transportation. Consignor routing of transportations of grain freights provides a concentration of their loading at junctions. The choice of junctions is proposed to be carried out on the basis of methods of the cluster analysis. For formation of regions for a concentration of grain loading the theory of sets and multicriteria optimization are used. As a result, on the basis of the modified simplex method are chosen 24 regions of possible concentration of grain loading that cover 70 stations on Ukrainian railways providing 7,5 million t consignor routing for grain in a year with minimal additional expenses. The assessment of the efficiency of railway transportation routing of grain freights is calculated with use of the developed simulation model. Researches showed that application of consignor routing allows to reduce a turn-round cycle for grain wagon in a logistic chain of deliveries up to 27%, and application of the schedule for consignor routes allows to reduce a turn-round cycle up to 62%, in comparison with transportation by car loading. Thus, as showed the calculations executed for one of the directions of grain transportation for export, the necessary operation park of grain-carrier wagons is reduced twice, thereby allowing to cut logistic expenses on a delivery of the Ukrainian grain through seaports to the world markets

Resource-saving technologies of railway transportation of grain freights for export

The research objective is to increase the efficiency of export railway transportation of grain freights in Ukraine by the introduction of consignor routing, a concentration of loading of grain on junction elevators and the organization of the movement of grain routes according to the schedule. According to the researchers in USA and EU, one of the effective directions for decreasing the expenses in a logistic chain of grain delivery to ports is consignor routing of railway transportation. Consignor routing of transportations of grain freights provides a concentration of their loading at junctions. The choice of junctions is proposed to be carried out on the basis of methods of the cluster analysis. For formation of regions for a concentration of grain loading the theory of sets and multicriteria optimization are used. As a result, on the basis of the modified simplex method are chosen 24 regions of possible concentration of grain loading that cover 70 stations on Ukrainian railways providing 7,5 million t consignor routing for grain in a year with minimal additional expenses. The assessment of the efficiency of railway transportation routing of grain freights is calculated with use of the developed simulation model. Researches showed that application of consignor routing allows to reduce a turn-round cycle for grain wagon in a logistic chain of deliveries up to 27%, and application of the schedule for consignor routes allows to reduce a turn-round cycle up to 62%, in comparison with transportation by car loading. Thus, as showed the calculations executed for one of the directions of grain transportation for export, the necessary operation park of grain-carrier wagons is reduced twice, thereby allowing to cut logistic expenses on a delivery of the Ukrainian grain through seaports to the world markets

Характеристика контамінації води відкритих водойм Одеської області найпростішими і гельмінтами

В работе представлена характеристика загрязнения открытых водоемов Одесской области простейшими и гельминтами. Обоснована необходимость проведения систематического мониторинга загрязнения лиманов этими биологическими контаминантами с применением современных методов исследований.In work the characteristic of pollution of оpen reservoirs of the Odessa area by protozoa and helmints is presented. Necessity of carrying out of regular monitoring of pollution of оpen reservoirs these biological contaminants with application of modern methods of researches is proved.У роботі представлена характеристика забруднення відкритих водойм Одеської області найпростішими і гельмінтами. Обґрунтована необхідність проведення систематичного моніторингу забруднення відкритих водойм цими біологічними контамінантами із застосуванням сучасних методів досліджень

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors

Despite the fact that the variola virus is considered eradicated, the search for new small molecules with activity against orthopoxviruses remains an important task, especially in the context of recent outbreaks of monkeypox. As a result of this work, a number of amides of benzoic acids containing an adamantane fragment were obtained. Most of the compounds demonstrated activity against vaccinia virus, with a selectivity index SI = 18,214 for the leader compound 18a. The obtained derivatives also demonstrated activity against murine pox (250 ≤ SI ≤ 6071) and cowpox (125 ≤ SI ≤ 3036). A correlation was obtained between the IC50 meanings and the binding energy to the assumed biological target, the p37 viral protein with R2 = 0.60