Investigation of the infusion solutions of different qualitative composition influence on the dynamics of neuron specific enolase activity in patients with acute ischemic stroke

At the moment, the question remains insufficiently studied what kind of infusion fluids or their combination should be preferred in patients with acute ischemic stroke (AIS) to provide intensive care. Purpose. To investigate the dynamics of neuron-specific enolase (NSE) against the background of the iso-osmolar 0.9 % NaCl solution, colloid iso-osmolar fluid HES 130, colloid hyperosmolar fluid HAES-LX-5 % and hyperosmolar fluid mannitol application in AIS. Materials and methods. The study included 32 patients with AIS. As the studied solutions were used: colloid hyperosmolar HAES-LX-5 % (Gekoton), colloid iso-osmolar hydroxyethyl crystal 6 % 130/04 (HES 130), hyperosmolar mannitol 15 %, and iso-osmolar 0.9 % NaCl. The control group consisted of patients receiving only 0.9 % NaCl, the comparison groups – the patients receiving 0.9 % NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 %, or 0.9 % NaCl + mannitol. NSE activity was used as a marker of cerebral ischemia at the corresponding time (the 1st, 4th and 7th days). Results. An increase in NSE (P < 0.05) was observed in the 0.9 % NaCl group at the 7th day of stroke. A similar dynamics of NSE elevation was in the group with mannitol (P < 0.05), as well as in the control group. A 17.3 % decrease in the NSE activity was noted in the application of HES 130 at the end of observation relative to the 1st day. The NSE activity decreased by 34.6 % (P < 0.05) on the 7th day in comparison with the 1st day in the HAES-LX-5 % group and was significantly less than in the control group, groups of HES 130 and mannitol – on average 2.88 times and 30.3 %, 39.8 %, respectively. Conclusions. The use of 0.9 % NaCl or 0.9 % NaCl + mannitol within 7 days in patients with AIS in addition to basic therapy was accompanied by an increase in NSE. Infusion of 0.9 % NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 % was accompanied by a decrease in NSE activity at the 7th day of treatment, herewith the HAES-LX-5 % group showed the best dynamics of NSE activity decreasing (P < 0.05)

SILICON MONOCRYSTALS FOR ALTERNATIVE ENERGY

This paper considers features of the formation and microstructure revealing of profound n- and p-type silicon monocrystals. Influence of hole and electron conductivity in semiconductors on the pattern of anodic etching is determined. Correlation among silicon microstructure, dislocation density and minority carriers’ lifetime has been studied. Influence of impurity diffusion from the surface into the space of the crystal on electrical properties’ changes of the semiconductor is shown

Research Library's Role and Place in the Educational Environment of Pedagogical University

The paper provides some results of the library reader survey which allowed establishing the new role and place of the research library of a pedagogical university. The creative role of the research library determines the possible options of interaction between the library and scientific and educational departments of the pedagogical university. In the educational environment, the library becomes a “third place” between home and classroom

Assessment of infusion therapy impact on the dynamics of endothelin-1 in patients with acute ischemic stroke

The impact of infusion solutions on endothelial damage correction in acute ischemic stroke (AIS) remains an insufficiently studied. Purpose. To investigate the dynamics of endothelin-1 as one of the main markers of vasoconstriction and endothelial dysfunction (ED) with the use of 0.9 % NaCl, HES 130, HAES-LX-5 % and mannitol in patients with AIS. Materials and methods. The study included 32 patients with AIS. As the investigated solutions were used: colloid hyperosmolar HAES-LX-5 % (Gecoton), colloid isoosmolar hydroxyethylstarch 6% 130/04 (HES 130), hyperosmolar mannitol 15 %, isoosmolar 0.9 % NaCl. The control group consisted of patients who received only 0.9 % NaCl, comparison group patients received 0.9% NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 %, or 0.9 % NaCl + mannitol. The level of endothelin-1 (EN-1) served as a vasoconstriction marker of ED at a fixed time (days 1, 4 and 7). Results. Infusion therapy with only 0.9 % NaCl negatively affected the level of EN-1, since its level was 3.17 times increased on the 7th day of observation in comparison with the 4th day (P 0.05) at the end of observation in comparison with mannitol and 0.9 % NaCl groups, which showed a paradoxical increase in its level at the 7th day of infusion. Conclusions. The dynamics of EN-1 level as the main vasoconstrictor marker of ED were negative in the group of patients with 0.9 % NaCl and mannitol: its level was 3.17 and 3.48 times increased in the 0.9 % NaCl and mannitol groups (P < 0,05), respectively, on day 7 compared to day 4 of observation. Intensive therapy with HAES-LX-5 % and HES 130 had a better depressing effect on an increase in EN-1 level than other solutions

Biochemical blood parameters and level of endogenous intoxication in cows suffering from hepatopathies under heat stress

Global warming results in increased extreme weather  events, including heatwaves,  droughts and floods, which exceed plants’and animals’tolerance thresholds, thus posing a threat to the economy and agriculture. Under these conditions, heat stress becomes a vital problem for animal husbandry. The paper presents the study results of biochemical blood parameters and endogenous intoxication in cows suffering from hepatopathies  under heat stress. Based on the calculated temperature-humidity  index, it was established that during the summer season in the conditions of the Krasnodar  Krai lowlands, cows are under heat stress. Using the method of paired comparisons, two groups of animals (n = 10) were formed: the first group was a healthy livestock; and the second group consisted of animals suffering from hepatic pathologies.  Blood was sampled from all cows at the beginning of the experiment (the first decade of May) and at the end (the last decade of July). Laboratory tests of blood revealed that as the heat stress develops healthy cows show the increase in the protein concentration in blood, and, on the contrary, animals with hepatic pathologies demonstrate the inhibition of protein synthesis. The higher activity of aminotransferases and alkaline phosphatase in the bovine serum in the summer season when compared to the spring season was established. The study of the endogenous intoxication level dynamics in cattle during the development of heat stress, showed that in both groups the concentrations of middle molecules (ММ) increased relative to the background data: in the first group (healthy cows) MM 237 – by 11.8%,  MM 254 – by 14.4%,  MM 280 – by 16.9%; in the second group (cattle with liver pathology)  MM 237 – by 16.9%,  MM 254 – by 20.3%,  MM 280 – by 33%. Thus, under heat stress, the endogenous intoxication in healthy livestock was almost 1.5 times less intense as compared to the animals suffering from hepatopathies

Anisotropic Magnetoconductance in Quench-Condensed Ultrathin Beryllium Films

Near the superconductor-insulator (S-I) transition, quench-condensed ultrathin Be films show a large magnetoconductance which is highly anisotropic in the direction of the applied field. Film conductance can drop as much as seven orders of magnitude in a weak perpendicular field (< 1 T), but is insensitive to a parallel field in the same field range. We believe that this negative magnetoconductance is due to the field de-phasing of the superconducting pair wavefunction. This idea enables us to extract the finite superconducting phase coherence length in nearly superconducting films. Our data indicate that this local phase coherence persists even in highly insulating films in the vicinity of the S-I transition.Comment: 4 pages, 4 figure RevTex, Typos Correcte

The role of active herpesvirus infection in the formation of atopic dermatitis and psoriasis

The results of previous studies suggest the involvement of herpes viruses in the development of atopic dermatitis and psoriasis, but there is no convincing evidence. Aim of the study was to evaluate the role of active herpesvirus infection in exacerbation of atopic dermatitis and psoriasis. Material and methods. The analysis of the incidence of infectious mononucleosis, genital herpes, cytomegalovirus infection, skin and subcutaneous tissue diseases, atopic dermatitis, psoriasis in Russia in 2000–2020 was carried out. 92 blood donors and 97 patients with skin and subcutaneous tissue diseases (44 with atopic dermatitis and 53 with psoriasis) were examined for the presence of immunoglobulins M and G to herpes simplex viruses (HSV1,2), Epstein-Barr (EBV), cytomegalovirus (CMV), human herpes type 6 (HНV6). Results and discussion. A significant strong direct correlation was revealed between the incidence of genital herpes and diseases of the skin and subcutaneous tissue (p = 0.85), atopic dermatitis (p = 0.85); infectious mononucleosis and psoriasis (p = 0.85). The frequency of detection of IgM to HSV1,2, in total, IgG EA and IgM VCA EBV in the group of patients is significantly higher than in donors (p &lt; 0.05). In patients with atopic dermatitis, IgM to HSV1 were detected significantly more often than in individuals with psoriasis, and markers of active EBV infection were significantly less common. The presence of IgM HSV-1 statistically significantly increases the incidence of atopic dermatitis (relative risk (RR) = 2.3, 95 % confidence interval (95 % CI) 1.6–3.3)), IgM VCA and IgG EA EBV – the incidence of psoriasis (RR = 2.3, 95 % CI 1.5–3.3). Conclusions. It has been shown for the first time that active HSV1,2 infection is a trigger factor for the development of atopic dermatitis, EBV infection is psoriasis