Medical requirements in support of long duration manned space flight

Medical support program for crew health and performance requirements in manned space flights of long duratio

Biological generalizations and the search for extraterrestrial life

Biological exploration for extraterrestrial lif

A historical reflection on the discovery of human retroviruses

The discovery of HIV-1 as the cause of AIDS was one of the major scientific achievements during the last century. Here the events leading to this discovery are reviewed with particular attention to priority and actual contributions by those involved. Since I would argue that discovering HIV was dependent on the previous discovery of the first human retrovirus HTLV-I, the history of this discovery is also re-examined. The first human retroviruses (HTLV-I) was first reported by Robert C. Gallo and coworkers in 1980 and reconfirmed by Yorio Hinuma and coworkers in 1981. These discoveries were in turn dependent on the previous discovery by Gallo and coworkers in 1976 of interleukin 2 or T-cell growth factor as it was called then. HTLV-II was described by Gallo's group in 1982. A human retrovirus distinct from HTLV-I and HTLV-II in that it was shown to have the morphology of a lentivirus was in my mind described for the first time by Luc Montagnier in an oral presentation at Cold Spring Harbor in September of 1983. This virus was isolated from a patient with lymphadenopathy using the protocol previously described for HTLV by Gallo. The first peer reviewed paper by Montagnier's group of such a retrovirus, isolated from two siblings of whom one with AIDS, appeared in Lancet in April of 1984. However, the proof that a new human retrovirus (HIV-1) was the cause of AIDS was first established in four publications by Gallo's group in the May 4th issue of Science in 1984

On the marketing Implications of place narratives

Acknowledging that locals are recognised as an important (yet neglected) dimension of place marketing and following critiques of places as products , the purpose of this paper is to give voice to local people . Drawing on local narratives of Santorini, Greece, we call attention to places as culturally significant and discursively produced and consumed. Local narratives provide multiple meanings constructed around the diverse and contested experiences of living and making a living in a place. Our analysis employs the metaphors of harsh beauty , service business and home to capture these perspectives. The paper has implications for the development of generative metaphors of place and local within place marketing and contributes to the dialogue over the continued relevance of our discipline to the public sphere