1,836 research outputs found

    Ectoplasm & Superspace Integration Measure for 2D Supergravity with Four Spinorial Supercurrents

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    Building on a previous derivation of the local chiral projector for a two dimensional superspace with eight real supercharges, we provide the complete density projection formula required for locally supersymmetrical theories in this context. The derivation of this result is shown to be very efficient using techniques based on the Ectoplasmic construction of local measures in superspace.Comment: 18 pages, LaTeX; V2: minor changes, typos corrected, references added; V3: version to appear in J. Phys. A: Math. Theor., some comments and references added to address a referee reques

    Palynofacies classification of the depositional elements of confined turbidite systems : Examples from the Gres d'Annot, SE France

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    Acknowledgements We thank BG Brasil for financial support for this project and permission to publish. BG Group is a wholly owned subsidiary of Royal Dutch Shell. McArthur is grateful to the Coordenação de Aperfeiçoamento de Pessoal de NĂ­vel Superior (CAPES) for the scholarship 049/2012. The AgĂȘncia Nacional do PetrĂłleo (ANP) are thanked for supporting this project. Massimo Zecchin is thanked for handling this paper and Roberto Tinterri is thanked for his constructive review, in addition to an anonymous reviewer.Peer reviewedPostprin

    Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders.

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    Plasma proteome composition reflects the inflammatory and metabolic state of the organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates are enriched with neurofilament heavy chain-axonal proteins involved in brain aggregate formation and recently identified as biomarkers of the fatal neuromuscular disorder amyotrophic lateral sclerosis. Using unbiased proteomic methods, we have fully characterized the content in neuronal proteins of circulating protein aggregates from amyotrophic lateral sclerosis patients and healthy controls, with reference to brain protein aggregate composition. We also investigated circulating protein aggregate protein aggregation propensity, stability to proteolytic digestion and toxicity for neuronal and endothelial cell lines. Circulating protein aggregates separated by ultracentrifugation are visible as electron-dense macromolecular particles appearing as either large globular or as small filamentous formations. Analysis by mass spectrometry revealed that circulating protein aggregates obtained from patients are enriched with proteins involved in the proteasome system, possibly reflecting the underlying basis of dysregulated proteostasis seen in the disease, while those from healthy controls show enrichment of proteins involved in metabolism. Compared to the whole human proteome, proteins within circulating protein aggregates and brain aggregates show distinct chemical features of aggregation propensity, which appear dependent on the tissue or fluid of origin and not on the health status. Neurofilaments' two high-mass isoforms (460 and 268 kDa) showed a strong differential expression in amyotrophic lateral sclerosis compared to healthy control circulating protein aggregates, while aggregated neurofilament heavy chain was also partially resistant to enterokinase proteolysis in patients, demonstrated by immunoreactive bands at 171 and 31 kDa fragments not seen in digested healthy controls samples. Unbiased proteomics revealed that a total of 4973 proteins were commonly detected in circulating protein aggregates and brain, including 24 expressed from genes associated with amyotrophic lateral sclerosis. Interestingly, 285 circulating protein aggregate proteins (5.7%) were regulated (P < 0.05) and are present in biochemical pathways linked to disease pathogenesis and protein aggregation. Biologically, circulating protein aggregates from both patients and healthy controls had a more pronounced effect on the viability of hCMEC/D3 endothelial and PC12 neuronal cells compared to immunoglobulins extracted from the same plasma samples. Furthermore, circulating protein aggregates from patients exerted a more toxic effect than healthy control circulating protein aggregates on both cell lines at lower concentrations (P: 0.03, in both cases). This study demonstrates that circulating protein aggregates are significantly enriched with brain proteins which are representative of amyotrophic lateral sclerosis pathology and a potential source of biomarkers and therapeutic targets for this incurable disorder

    Photometry and Spectroscopy of the Optical Companion to the Pulsar PSR J1740-5340 in the Globular Cluster NGC 6397

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    We present photometric and spectroscopic observations of the optical companion to the millisecond radio pulsar PSR J1740-5340 in the globular cluster NGC 6397. An analysis of the photometric variability in the B, V, and I-bands indicates an inclination of the system of 43.9+-2.1 degrees if the optical companion fills its Roche lobe (a semi-detached configuration). The spectroscopic data show a radial velocity variation with a semi-amplitude of K=137.2 +- 2.4 km/sec, and a system velocity gamma=17.6 +- 1.5 km/sec, consistent with cluster membership. We use these results to derive a mass of the optical companion of M1=0.296 +- 0.034 Msol and M2=1.53 +- 0.19 Msol for the pulsar. There is evidence for secular change of the amplitude of the optical light curve of the variable measured over seven years. The change does not have interpretation and its presence complicates reliable determination of the absolute parameters of the binary.Comment: 24 pages, 9 figures, submitted to A

    Darboux Transformations for Supersymmetric Korteweg - de Vries Equations

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    \hspace{.2in}We consider the Darboux type transformations for the spectral problems of supersymmetric KdV systems. The supersymmetric analogies of Darboux and Darboux-Levi transformations are established for the spectral problems of Manin-Radul-Mathieu sKdV and Manin-Radul sKdV. Several B\"acklund transformations are derived for the MRM sKdV and MR sKdV systems.Comment: Latex, 8 pages AS-ITP-94-4

    On the Background Field Method Beyond One Loop: A manifestly covariant derivative expansion in super Yang-Mills theories

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    There are currently many string inspired conjectures about the structure of the low-energy effective action for super Yang-Mills theories which require explicit multi-loop calculations. In this paper, we develop a manifestly covariant derivative expansion of superspace heat kernels and present a scheme to evaluate multi-loop contributions to the effective action in the framework of the background field method. The crucial ingredient of the construction is a detailed analysis of the properties of the parallel displacement propagators associated with Yang-Mills supermultiples in N-extended superspace.Comment: 32 pages, latex, 7 EPS figures. v2: references, comments added, typos corrected, incorrect `skeleton' conjecture in sect. 3 replaced by a more careful treatment. v3: typos corrected, final version published in JHE

    Supercritical flows overspilling from bypass‐dominated submarine channels and the development of overbank bedforms

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    Overbank deposits of submarine channels are typically thin‐bedded, fine‐grained and predominantly characterized by a series of sedimentary structures interpreted to record a relatively simple history of waning flow. Here, a new type of bedform indicative of Froude‐supercritical flow is reported from successions of thin‐bedded turbidites interpreted as channel overbank deposits in the Upper Cretaceous Rosario Formation, Baja California, Mexico. A link is demonstrated between the development of overbank deposits in the form of depositional terraces or internal levees and contemporaneously active sediment transport, bypass and deposition of coarser‐grained material in a channel. The overbank bedforms overlie an erosion surface and contain a suite of sedimentary structures indicative of initially Froude‐supercritical flow conditions and a progressive waning of flow strength. In some cases, a stacked repetition of facies is interpreted to record a rejuvenation of flow energy. The characteristic sedimentary sequence observed is as follows: (a) long wavelength, low amplitude erosional surface with superimposed scours; (b) antidune backsets; (c) upper stage plane‐parallel lamination; (d) subcritical climbing ripples; (e) supercritical climbing ripples; (f) lower stage planar laminated tops; (g) a sharp upper surface. The exact vertical sequence of sedimentary structures encountered varies depending on the point of observation with respect to the bedform crest and distance from the parent channel. The recognition of these distinctive bedforms allows for interpretation of sediment bypass and proximity to a channel thalweg. These bedforms have not hitherto been described and provide a further example of the range of flow processes operating in submarine channel–levee systems, which aids depositional environment interpretation in both subsurface and outcrop studies

    Wess-Zumino Terms in Supersymmetric Gauge Theories

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    The Wess-Zumino term is constructed for supersymmetric QCD with two colors and flavors, and is shown to correctly reproduce the anomalous Ward identities. Supersymmetric QCD is also shown not to have topologically stable skyrmion solutions because of baryon flat directions, which allow them to unwind. The generalization of these results to other supersymmetric theories with quantum modified constraints is discussed.Comment: 4 pages (revtex

    Effective Average Action in N=1 Super-Yang-Mills Theory

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    For N=1 Super-Yang-Mills theory we generalize the effective average action Gamma_k in a manifest supersymmetric way using the superspace formalism. The exact evolution equation for Gamma_k is derived and, introducing as an application a simple truncation, the standard one-loop beta-function of N=1 SYM theory is obtained.Comment: 17 pages, LaTeX, some remarks added, misprints corrected, to appear in Phys. Rev.

    Personalisation and recommender systems in digital libraries

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    Widespread use of the Internet has resulted in digital libraries that are increasingly used by diverse communities of users for diverse purposes and in which sharing and collaboration have become important social elements. As such libraries become commonplace, as their contents and services become more varied, and as their patrons become more experienced with computer technology, users will expect more sophisticated services from these libraries. A simple search function, normally an integral part of any digital library, increasingly leads to user frustration as user needs become more complex and as the volume of managed information increases. Proactive digital libraries, where the library evolves from being passive and untailored, are seen as offering great potential for addressing and overcoming these issues and include techniques such as personalisation and recommender systems. In this paper, following on from the DELOS/NSF Working Group on Personalisation and Recommender Systems for Digital Libraries, which met and reported during 2003, we present some background material on the scope of personalisation and recommender systems in digital libraries. We then outline the working group’s vision for the evolution of digital libraries and the role that personalisation and recommender systems will play, and we present a series of research challenges and specific recommendations and research priorities for the field
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