Research into possibilities of reducing the X155CrVMo12-1 tool steel fragility

This research varies the parameters of austenitization and quenching of the tool steel X155CrVMo12-1. It also focuses on investigation of the structure, hardness and impact energy. It was determined that the cracks were generally intercrystalline, with carbide deposition. It was observed that quenching at the temperature interval from ≈ 700 °C to ≈ 600 °C, at a speed greater than 15 °C/s, achieved higher impact energy with about the same hardness. It was concluded that prevention of carbide coalescence had influence on the reduction of steel fragility

MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma

In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases

Effect of litter type and perches on footpad dermatitis and hock burn in broilers housed at different stocking densities

The aim of the study was to assess the effect of litter type and environmental enrichment on the occurrence of footpad dermatitis and hock burns in broilers housed at low and high stocking densities. Chopped straw and sand were used as litter, and perches as environmental enrichment. Low and high stocking density implied 12 chickens/m2 and 20 chickens/m2, respectively. The study sample was divided into four groups of 50 birds, which were observed during a six-week fattening period. A significantly higher rate of severe footpad dermatitis was recorded in the group of chickens raised on sand at high stocking density, compared with low stocking density, whereas no significant difference was found between the groups of chickens raised on straw at different stocking densities. The rate of footpad dermatitis was also significantly higher in the group of chickens raised on sand at high stocking density, compared with chickens raised on straw at the same stocking density. There were no group differences in the occurrences of hock burns and perching. However, a significant negative correlation was recorded between perching and the occurrence of footpad dermatitis and hock burns. According to the occurrence of footpad dermatitis and hock burns, the study results suggested that chopped straw and sand were equally acceptable as litter for broilers, yet sand should be avoided at high stocking densities. There was no effect of stocking density and litter type on perching, but perches as a form of environmental enrichment proved efficient in reducing the rate of footpad dermatitis and hock burns.Keywords: chickens, contact dermatitis, environmental enrichment, housing, san

Delphi survey on the most promising areas and methods to improve systematic reviews' production and updating

BACKGROUND: Systematic reviews (SRs) are invaluable evidence syntheses, widely used in biomedicine and other scientific areas. Tremendous resources are being spent on the production and updating of SRs. There is a continuous need to automatize the process and use the workforce and resources to make it faster and more efficient. METHODS: Information gathered by previous EVBRES research was used to construct a questionnaire for round 1 which was partly quantitative, partly qualitative. Fifty five experienced SR authors were invited to participate in a Delphi study (DS) designed to identify the most promising areas and methods to improve the efficient production and updating of SRs. Topic questions focused on which areas of SRs are most time/effort/resource intensive and should be prioritized in further research. Data were analysed using NVivo 12 plus, Microsoft Excel 2013 and SPSS. Thematic analysis findings were used on the topics on which agreement was not reached in round 1 in order to prepare the questionnaire for round 2. RESULTS: Sixty percent (33/55) of the invited participants completed round 1; 44% (24/55) completed round 2. Participants reported average of 13.3 years of experience in conducting SRs (SD 6.8). More than two thirds of the respondents agreed/strongly agreed the following topics should be prioritized: extracting data, literature searching, screening abstracts, obtaining and screening full texts, updating SRs, finding previous SRs, translating non-English studies, synthesizing data, project management, writing the protocol, constructing the search strategy and critically appraising. Participants have not considered following areas as priority: snowballing, GRADE-ing, writing SR, deduplication, formulating SR question, performing meta-analysis. CONCLUSIONS: Data extraction was prioritized by the majority of participants as an area that needs more research/methods development. Quality of available language translating tools has dramatically increased over the years (Google translate, DeepL). The promising new tool for snowballing emerged (Citation Chaser). Automation cannot substitute human judgement where complex decisions are needed (GRADE-ing). TRIAL REGISTRATION: Study protocol was registered at https://osf.io/bp2hu/