STUDY OF ADHESION ACTIVITY GEL COMPOSITIONS TRIMECAINE

Local anesthesia is an integral component of medical procedures in today's children's dental practice. Enumeration of intraoral drugs containing anesthetics, for pediatric dentistry is extremely insufficient. Urgent is the development of children and of the dental gel containing trimekain, for application anesthesia. The purpose of this study was to study the adhesive properties of comparative gel compositions containing various combinations and trimekain potential of shaping. The studies revealed gel compositions with excellent adhesion characteristics, which can be recommended for further screening on the creation of children's dental gel trimecaine

Factor analysis of profit wholesale-retail pharmaceutical companies

The results of the analysis of the factors affecting the net profit and profitability of the pharmaceutical company. As an object of research performed one of the typical wholesale-retail pharmaceutical organizations. During the analysis found a negative effect on the value of absolute values of gross and net profit decrease in total turnover for 2009-2014 years. to 41.62%, revealed a compensatory effect on the value of the level of gross profit and net profit, changes in the structure of total turnover in the direction of increasing the proportion of groups with higher marginal income, and also demonstrated a negative effect on the growth of levels of financial performance costs

Mineral composition supercritical carbon dioxide seed extract ringlets seeding

The paper presents the results of a study of the mineral composition of supercritical carbon dioxide extracts № 1, № 2 and number 3 seed black cumin seed by capillary electrophoresis. According to the research found that in all the carbon dioxide extracts were identified 8 minerals (potassium, sodium, magnesium, calcium, copper, zinc, iron and manganese). The maximum content in the extract macronutrients observed number 2 (2966±78 mg/kg). As regards minerals, the dominating amount of the extract was concentrated in the number 3 (27,3±0,82 mg/kg). When studying the quantitative content of the individual elements, it was found that the number of the extract 2 prevailing amount were found potassium, magnesium and calcium. High concentrations of sodium, zinc and copper were observed in the extract of number 3. Extract number 1 differed from extracts number 2 and number 3 maximum content of iron and manganese. Thus, the results of the study of supercritical carbon dioxide extracts from the seeds of black cumin seed in respect of macro- and micronutrients indicate their degree of enrichment of the most important combinations of minerals

Development of composition and technology of children's dental films with anesthetic and anti-inflammatory activity

The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity. Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar. Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g. Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers

Розробка складу й технології дитячих стоматологічних плівок анестезувальної та протизапальної дії

The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity.Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar.Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g.Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers.Цель работы – разработка состава и технологии детских стоматологических плёнок анестезирующего и противовоспалительного действия.Материалы и методы. Для проведения исследований применяли фармацевтическую субстанцию тримекаина, цветки ромашки аптечной и вспомогательные вещества: натрий-карбоксиметилцеллюлозу, желатин, полиэтиленоксид-600, воду очищенную, разрешённые к медицинскому применению и отвечающие требованиям соответствующей нормативной документации. Водное извлечение из цветков ромашки аптечной получали в лабораторных условиях методом ремацерации с соблюдением принятых для данного способа технологических правил. Содержание суммы флавоноидов в пересчёте на рутин в цветках ромашки и полученных водных извлечениях определяли спектрофотометрически по фармакопейной методике. Растворы плёнкообразователей готовили в соответствии с их физико-химическими свойствами и рекомендуемыми технологическими режимами приготовления. Стоматологические плёнки получали методом полива плёночной массы на стеклянную подложку с последующим высушиванием. С целью выбора оптимального состава стоматологических плёнок исследовали их адгезионные свойства, осмотическую активность и биофармацевтические показатели. Адгезионную активность плёнок изучали по методике, основанной на определении силы отрыва стеклянных пластинок друг от друга. Осмотическую активность плёнок определяли методом диализа через полупроницаемую мембрану. Биофармацевтические свойства оценивали методом диффузии в агар.Результаты. Установлено, что наиболее подходящим способом получения водного извлечения из цветков ромашки является трёхступенчатая ремацерация горячей водой очищенной, позволяющая извлечь более 70 % суммы флавоноидов из исходного сырья. Для определения рационального сочетания вспомогательных компонентов плёночной матрицы было приготовлено несколько различных композиций, включающих натрий-карбоксиметилцеллюлозу, желатин, полиэтиленоксид-600, тримекаин, натрия бензоат и водное извлечение из цветков ромашки. Полученные плёнки представляли собой гибкие упругие пластины светло-коричневого цвета с приятным специфическим запахом и вкусом, характерным для органолептических свойств цветков ромашки. В результате сравнительного изучения адгезионной, осмотической активности и биофармацевтических свойств экспериментальных образцов плёнок установлено, что наиболее оптимальный состав данной лекарственной формы включает 0,2 г тримекаина; 2,0 г натрий-карбоксиметилцеллюлозы; 2,0 г желатина; 2,0 г полиэтиленоксида-600; 0,01 г натрия бензоата и водное извлечение из цветков ромашки до 100,0 г.Выводы. Разработан состав и технология детских стоматологических плёнок анестезирующего и противовоспалительного действия, содержащих тримекаин и водное извлечение из цветков ромашки.Мета роботи – розробка складу та технології дитячих стоматологічних плівок анестезувальної і протизапальної дії.Матеріали та методи. Для досліджень застосували фармацевтичну субстанцію тримекаїну, квітки ромашки аптечної та допоміжні речовини: натрію карбоксиметилцелюлозу, желатин, поліетиленоксид-600, воду очищену, дозволені до медичного застосування та такі, що відповідають вимогам відповідної нормативної документації. Водне витягання з квіток ромашки аптечної отримували в лабораторних умовах методом ремацерації з дотриманням прийнятих для цього способу технологічних правил. Зміст суми флавоноїдів у перерахунку на рутин у квітках ромашки та водних витяганнях, що отримали, визначали спектрофотометрично за фармакопейною методикою. Розчини плівкоутворювачів готували відповідно до їхніх фізико-хімічних властивостей і рекомендованих технологічних режимів приготування. Стоматологічні плівки отримували методом поливу плівкової маси на скляну підкладку з наступним висушуванням. З метою вибору оптимального складу стоматологічних плівок досліджували їхні адгезійні властивості, осмотичну активність і біофармацевтичні показники. Адгезійну активність плівок вивчали за методикою, що заснована на визначенні сили відриву скляних пластинок одна від одної. Осмотичну активність плівок визначали методом діалізу через напівпроникну мембрану. Біофармацевтичні властивості оцінювали методом дифузії в агар.Результати. Встановили, що найбільш відповідним способом отримання водного витягання з квіток ромашки є триступінчата ремацерація гарячою водою очищеною, що дає можливість витягнути понад 70 % суми флавоноїдів із початкової сировини. Для визначення раціонального поєднання допоміжних компонентів плівкової матриці приготували кілька різних композицій, що включають натрію карбоксиметилцелюлозу, желатин, поліетиленоксид-600, тримекаїн, натрію бензоат і водне витягання з квіток ромашки. Отримані плівки були гнучкими, пружними пластинами світло-коричневого кольору з приємним специфічним запахом і смаком, що  характерний для органолептичних властивостей квіток ромашки. У результаті порівняльного вивчення адгезійної, осмотичної активності та біофармацевтичних властивостей експериментальних зразків плівок встановили: найоптимальніший склад цієї лікарської форми включає 0,2 г тримекаїну; 2,0 г натрію карбоксиметилцелюлози; 2,0 г желатину; 2,0 г поліетиленоксиду-600; 0,01 г натрію бензоату та водне витягання з квіток ромашки до 100,0 г.Висновки. Розроблений склад і технологія дитячих стоматологічних плівок анестезувальної та протизапальної дії, котрі містять тримекаїн і водне витягання з квіток ромашки

Development of composition and technology of children's dental films with anesthetic and anti-inflammatory activity

The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity. Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar. Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g. Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers

DEVELOPMENT OF TECHNOLOGY FOR DRY EXTRACT OF GRASS HARROW THE FIELD

The urgency of developing a drug laxative action of grass harrow the field in the form of dry extract. The technology of dry extract of grass harrow using the method of vacuum filtration of extraction. A quantification of the active ingredients – phenolic compounds of a dry extract of grass harrow causing its laxative effect. The total content of phenolic compounds (isoflavones, flavonoids, phenolcarbonic acids) in phytopreparations harrow was about 25 %

Development method for quantitative determination of thymoquinone in seeds nigella sativa

The technique of quantitative determination of thymoquinone black cumin seeds sown by the method of capillary electrophoresis. Held its validation parameters: specificity, linearity, accuracy and precision. Electrophoretic technique can be used for valuation and assessment of quality of raw materials blackie by active ingredient - thymoquinone

THE FEASIBILITY AND POSSIBLE WAYS COMPLEX PROCESSING OF FRUITS SOPHORA JAPONICA

The fruits of Sophora japonica has long been successfully used as an antiseptic. However, despite the long period of application, the range of medicines produced from the fruit of Sophora japonica, has not changed and is still limited. One way to solve this problem is to implement a comprehensive recycling Sophora fruit. In this regard, the purpose was to study the possibilities of studies of complex processing them by the fruit of Sophora sequential extraction with extractants bipolar and antimicrobial activity of the resulting fractions with biologically active substances. It revealed that most rational for bipolar fractions of fruit of Sophora - potential drugs extractants use is as follows: 95% ethyl alcohol, 70% ethyl alcohol, purified water

Method of surgical treatment of the central hernias of an intervertebral disk on a lumbar level

In given article the new method of treatment of the central hernias of a lumbar level of a backbone in comparison with other methods forward and back decompression spinal canal is described. Indications and contrindications to the specified method, advantages and lacks of existing methods of treatment of stenoses vertebral channel