13 research outputs found
STUDY OF ADHESION ACTIVITY GEL COMPOSITIONS TRIMECAINE
Local anesthesia is an integral component of medical procedures in today's children's dental practice. Enumeration of intraoral drugs containing anesthetics, for pediatric dentistry is extremely insufficient. Urgent is the development of children and of the dental gel containing trimekain, for application anesthesia. The purpose of this study was to study the adhesive properties of comparative gel compositions containing various combinations and trimekain potential of shaping. The studies revealed gel compositions with excellent adhesion characteristics, which can be recommended for further screening on the creation of children's dental gel trimecaine
Factor analysis of profit wholesale-retail pharmaceutical companies
The results of the analysis of the factors affecting the net profit and profitability of the pharmaceutical company. As an object of research performed one of the typical wholesale-retail pharmaceutical organizations. During the analysis found a negative effect on the value of absolute values of gross and net profit decrease in total turnover for 2009-2014 years. to 41.62%, revealed a compensatory effect on the value of the level of gross profit and net profit, changes in the structure of total turnover in the direction of increasing the proportion of groups with higher marginal income, and also demonstrated a negative effect on the growth of levels of financial performance costs
Mineral composition supercritical carbon dioxide seed extract ringlets seeding
The paper presents the results of a study of the mineral composition of supercritical carbon dioxide extracts β 1, β 2 and number 3 seed black cumin seed by capillary electrophoresis. According to the research found that in all the carbon dioxide extracts were identified 8 minerals (potassium, sodium, magnesium, calcium, copper, zinc, iron and manganese). The maximum content in the extract macronutrients observed number 2 (2966Β±78 mg/kg). As regards minerals, the dominating amount of the extract was concentrated in the number 3 (27,3Β±0,82 mg/kg). When studying the quantitative content of the individual elements, it was found that the number of the extract 2 prevailing amount were found potassium, magnesium and calcium. High concentrations of sodium, zinc and copper were observed in the extract of number 3. Extract number 1 differed from extracts number 2 and number 3 maximum content of iron and manganese. Thus, the results of the study of supercritical carbon dioxide extracts from the seeds of black cumin seed in respect of macro- and micronutrients indicate their degree of enrichment of the most important combinations of minerals
Development of composition and technology of children's dental films with anesthetic and anti-inflammatory activity
The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity.
Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar.
Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g.
Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers
Π ΠΎΠ·ΡΠΎΠ±ΠΊΠ° ΡΠΊΠ»Π°Π΄Ρ ΠΉ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΡΡ Π΄ΠΈΡΡΡΠΈΡ ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ ΠΏΠ»ΡΠ²ΠΎΠΊ Π°Π½Π΅ΡΡΠ΅Π·ΡΠ²Π°Π»ΡΠ½ΠΎΡ ΡΠ° ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π΄ΡΡ
The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity.Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar.Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g.Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠΎΡΡΠ°Π²Π° ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π΄Π΅ΡΡΠΊΠΈΡ
ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ»ΡΠ½ΠΎΠΊ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΡ ΡΡΠΈΠΌΠ΅ΠΊΠ°ΠΈΠ½Π°, ΡΠ²Π΅ΡΠΊΠΈ ΡΠΎΠΌΠ°ΡΠΊΠΈ Π°ΠΏΡΠ΅ΡΠ½ΠΎΠΉ ΠΈ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π°: Π½Π°ΡΡΠΈΠΉ-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»Π»ΡΠ»ΠΎΠ·Ρ, ΠΆΠ΅Π»Π°ΡΠΈΠ½, ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄-600, Π²ΠΎΠ΄Ρ ΠΎΡΠΈΡΠ΅Π½Π½ΡΡ, ΡΠ°Π·ΡΠ΅ΡΡΠ½Π½ΡΠ΅ ΠΊ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΌΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΡΠ²Π΅ΡΠ°ΡΡΠΈΠ΅ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ. ΠΠΎΠ΄Π½ΠΎΠ΅ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ· ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ Π°ΠΏΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΠΌΠ°ΡΠ΅ΡΠ°ΡΠΈΠΈ Ρ ΡΠΎΠ±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈΠ½ΡΡΡΡ
Π΄Π»Ρ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΏΠΎΡΠΎΠ±Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ°Π²ΠΈΠ». Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΡΠΌΠΌΡ ΡΠ»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² Π² ΠΏΠ΅ΡΠ΅ΡΡΡΡΠ΅ Π½Π° ΡΡΡΠΈΠ½ Π² ΡΠ²Π΅ΡΠΊΠ°Ρ
ΡΠΎΠΌΠ°ΡΠΊΠΈ ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π²ΠΎΠ΄Π½ΡΡ
ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡΡ
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΏΠ΅ΠΉΠ½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ΅. Π Π°ΡΡΠ²ΠΎΡΡ ΠΏΠ»ΡΠ½ΠΊΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Π³ΠΎΡΠΎΠ²ΠΈΠ»ΠΈ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΈΡ
ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΠ΅ΠΌΡΠΌΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅ΠΆΠΈΠΌΠ°ΠΌΠΈ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ. Π‘ΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ»ΡΠ½ΠΊΠΈ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠ²Π° ΠΏΠ»ΡΠ½ΠΎΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π½Π° ΡΡΠ΅ΠΊΠ»ΡΠ½Π½ΡΡ ΠΏΠΎΠ΄Π»ΠΎΠΆΠΊΡ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ Π²ΡΡΡΡΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ. Π‘ ΡΠ΅Π»ΡΡ Π²ΡΠ±ΠΎΡΠ° ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ»ΡΠ½ΠΎΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΈΡ
Π°Π΄Π³Π΅Π·ΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±ΠΈΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ. ΠΠ΄Π³Π΅Π·ΠΈΠΎΠ½Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠ»ΡΠ½ΠΎΠΊ ΠΈΠ·ΡΡΠ°Π»ΠΈ ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ΅, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠΈΠ»Ρ ΠΎΡΡΡΠ²Π° ΡΡΠ΅ΠΊΠ»ΡΠ½Π½ΡΡ
ΠΏΠ»Π°ΡΡΠΈΠ½ΠΎΠΊ Π΄ΡΡΠ³ ΠΎΡ Π΄ΡΡΠ³Π°. ΠΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠ»ΡΠ½ΠΎΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΠ°Π»ΠΈΠ·Π° ΡΠ΅ΡΠ΅Π· ΠΏΠΎΠ»ΡΠΏΡΠΎΠ½ΠΈΡΠ°Π΅ΠΌΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ. ΠΠΈΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΡΠ·ΠΈΠΈ Π² Π°Π³Π°Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΡΡΠΈΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈΠ· ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΡ
ΡΡΡΠΏΠ΅Π½ΡΠ°ΡΠ°Ρ ΡΠ΅ΠΌΠ°ΡΠ΅ΡΠ°ΡΠΈΡ Π³ΠΎΡΡΡΠ΅ΠΉ Π²ΠΎΠ΄ΠΎΠΉ ΠΎΡΠΈΡΠ΅Π½Π½ΠΎΠΉ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ°Ρ ΠΈΠ·Π²Π»Π΅ΡΡ Π±ΠΎΠ»Π΅Π΅ 70 % ΡΡΠΌΠΌΡ ΡΠ»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² ΠΈΠ· ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΡΡΡΡ. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΡ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΏΠ»ΡΠ½ΠΎΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΈΡΡ Π±ΡΠ»ΠΎ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΎ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΈΠΉ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΡ
Π½Π°ΡΡΠΈΠΉ-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»Π»ΡΠ»ΠΎΠ·Ρ, ΠΆΠ΅Π»Π°ΡΠΈΠ½, ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄-600, ΡΡΠΈΠΌΠ΅ΠΊΠ°ΠΈΠ½, Π½Π°ΡΡΠΈΡ Π±Π΅Π½Π·ΠΎΠ°Ρ ΠΈ Π²ΠΎΠ΄Π½ΠΎΠ΅ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ· ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΏΠ»ΡΠ½ΠΊΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ»ΠΈ ΡΠΎΠ±ΠΎΠΉ Π³ΠΈΠ±ΠΊΠΈΠ΅ ΡΠΏΡΡΠ³ΠΈΠ΅ ΠΏΠ»Π°ΡΡΠΈΠ½Ρ ΡΠ²Π΅ΡΠ»ΠΎ-ΠΊΠΎΡΠΈΡΠ½Π΅Π²ΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° Ρ ΠΏΡΠΈΡΡΠ½ΡΠΌ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π·Π°ΠΏΠ°Ρ
ΠΎΠΌ ΠΈ Π²ΠΊΡΡΠΎΠΌ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΌ Π΄Π»Ρ ΠΎΡΠ³Π°Π½ΠΎΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π°Π΄Π³Π΅Π·ΠΈΠΎΠ½Π½ΠΎΠΉ, ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π±ΠΈΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΏΠ»ΡΠ½ΠΎΠΊ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ ΡΠΎΡΡΠ°Π² Π΄Π°Π½Π½ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠΎΡΠΌΡ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ 0,2 Π³ ΡΡΠΈΠΌΠ΅ΠΊΠ°ΠΈΠ½Π°; 2,0 Π³ Π½Π°ΡΡΠΈΠΉ-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»Π»ΡΠ»ΠΎΠ·Ρ; 2,0 Π³ ΠΆΠ΅Π»Π°ΡΠΈΠ½Π°; 2,0 Π³ ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄Π°-600; 0,01 Π³ Π½Π°ΡΡΠΈΡ Π±Π΅Π½Π·ΠΎΠ°ΡΠ° ΠΈ Π²ΠΎΠ΄Π½ΠΎΠ΅ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ· ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ Π΄ΠΎ 100,0 Π³.ΠΡΠ²ΠΎΠ΄Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠΎΡΡΠ°Π² ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ Π΄Π΅ΡΡΠΊΠΈΡ
ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ»ΡΠ½ΠΎΠΊ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΡΡΠΈΠΌΠ΅ΠΊΠ°ΠΈΠ½ ΠΈ Π²ΠΎΠ΄Π½ΠΎΠ΅ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ· ΡΠ²Π΅ΡΠΊΠΎΠ² ΡΠΎΠΌΠ°ΡΠΊΠΈ.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ β ΡΠΎΠ·ΡΠΎΠ±ΠΊΠ° ΡΠΊΠ»Π°Π΄Ρ ΡΠ° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ Π΄ΠΈΡΡΡΠΈΡ
ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΠ»ΡΠ²ΠΎΠΊ Π°Π½Π΅ΡΡΠ΅Π·ΡΠ²Π°Π»ΡΠ½ΠΎΡ Ρ ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π΄ΡΡ.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ»Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π·Π°ΡΡΠΎΡΡΠ²Π°Π»ΠΈ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½Ρ ΡΡΠ±ΡΡΠ°Π½ΡΡΡ ΡΡΠΈΠΌΠ΅ΠΊΠ°ΡΠ½Ρ, ΠΊΠ²ΡΡΠΊΠΈ ΡΠΎΠΌΠ°ΡΠΊΠΈ Π°ΠΏΡΠ΅ΡΠ½ΠΎΡ ΡΠ° Π΄ΠΎΠΏΠΎΠΌΡΠΆΠ½Ρ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ΠΈ: Π½Π°ΡΡΡΡ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»ΡΠ»ΠΎΠ·Ρ, ΠΆΠ΅Π»Π°ΡΠΈΠ½, ΠΏΠΎΠ»ΡΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄-600, Π²ΠΎΠ΄Ρ ΠΎΡΠΈΡΠ΅Π½Ρ, Π΄ΠΎΠ·Π²ΠΎΠ»Π΅Π½Ρ Π΄ΠΎ ΠΌΠ΅Π΄ΠΈΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ ΡΠ° ΡΠ°ΠΊΡ, ΡΠΎ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π°ΡΡΡ Π²ΠΈΠΌΠΎΠ³Π°ΠΌ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎΡ Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°ΡΡΡ. ΠΠΎΠ΄Π½Π΅ Π²ΠΈΡΡΠ³Π°Π½Π½Ρ Π· ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ Π°ΠΏΡΠ΅ΡΠ½ΠΎΡ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΈΡ
ΡΠΌΠΎΠ²Π°Ρ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΠΌΠ°ΡΠ΅ΡΠ°ΡΡΡ Π· Π΄ΠΎΡΡΠΈΠΌΠ°Π½Π½ΡΠΌ ΠΏΡΠΈΠΉΠ½ΡΡΠΈΡ
Π΄Π»Ρ ΡΡΠΎΠ³ΠΎ ΡΠΏΠΎΡΠΎΠ±Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΡΠ°Π²ΠΈΠ». ΠΠΌΡΡΡ ΡΡΠΌΠΈ ΡΠ»Π°Π²ΠΎΠ½ΠΎΡΠ΄ΡΠ² Ρ ΠΏΠ΅ΡΠ΅ΡΠ°Ρ
ΡΠ½ΠΊΡ Π½Π° ΡΡΡΠΈΠ½ Ρ ΠΊΠ²ΡΡΠΊΠ°Ρ
ΡΠΎΠΌΠ°ΡΠΊΠΈ ΡΠ° Π²ΠΎΠ΄Π½ΠΈΡ
Π²ΠΈΡΡΠ³Π°Π½Π½ΡΡ
, ΡΠΎ ΠΎΡΡΠΈΠΌΠ°Π»ΠΈ, Π²ΠΈΠ·Π½Π°ΡΠ°Π»ΠΈ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ½ΠΎ Π·Π° ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΏΠ΅ΠΉΠ½ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΎΡ. Π ΠΎΠ·ΡΠΈΠ½ΠΈ ΠΏΠ»ΡΠ²ΠΊΠΎΡΡΠ²ΠΎΡΡΠ²Π°ΡΡΠ² Π³ΠΎΡΡΠ²Π°Π»ΠΈ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎ Π΄ΠΎ ΡΡ
Π½ΡΡ
ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½ΠΈΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΡΠ΅ΠΆΠΈΠΌΡΠ² ΠΏΡΠΈΠ³ΠΎΡΡΠ²Π°Π½Π½Ρ. Π‘ΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ ΠΏΠ»ΡΠ²ΠΊΠΈ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠ²Ρ ΠΏΠ»ΡΠ²ΠΊΠΎΠ²ΠΎΡ ΠΌΠ°ΡΠΈ Π½Π° ΡΠΊΠ»ΡΠ½Ρ ΠΏΡΠ΄ΠΊΠ»Π°Π΄ΠΊΡ Π· Π½Π°ΡΡΡΠΏΠ½ΠΈΠΌ Π²ΠΈΡΡΡΡΠ²Π°Π½Π½ΡΠΌ. Π ΠΌΠ΅ΡΠΎΡ Π²ΠΈΠ±ΠΎΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΊΠ»Π°Π΄Ρ ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΠ»ΡΠ²ΠΎΠΊ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈ ΡΡ
Π½Ρ Π°Π΄Π³Π΅Π·ΡΠΉΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ, ΠΎΡΠΌΠΎΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Ρ Π±ΡΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½Ρ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ. ΠΠ΄Π³Π΅Π·ΡΠΉΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠ»ΡΠ²ΠΎΠΊ Π²ΠΈΠ²ΡΠ°Π»ΠΈ Π·Π° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΎΡ, ΡΠΎ Π·Π°ΡΠ½ΠΎΠ²Π°Π½Π° Π½Π° Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠΈΠ»ΠΈ Π²ΡΠ΄ΡΠΈΠ²Ρ ΡΠΊΠ»ΡΠ½ΠΈΡ
ΠΏΠ»Π°ΡΡΠΈΠ½ΠΎΠΊ ΠΎΠ΄Π½Π° Π²ΡΠ΄ ΠΎΠ΄Π½ΠΎΡ. ΠΡΠΌΠΎΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΠ»ΡΠ²ΠΎΠΊ Π²ΠΈΠ·Π½Π°ΡΠ°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΡΠ°Π»ΡΠ·Ρ ΡΠ΅ΡΠ΅Π· Π½Π°ΠΏΡΠ²ΠΏΡΠΎΠ½ΠΈΠΊΠ½Ρ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ. ΠΡΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ ΠΎΡΡΠ½ΡΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΠ·ΡΡ Π² Π°Π³Π°Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ, ΡΠΎ Π½Π°ΠΉΠ±ΡΠ»ΡΡ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΠΎΡΡΠΈΠΌΠ°Π½Π½Ρ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΈΡΡΠ³Π°Π½Π½Ρ Π· ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ Ρ ΡΡΠΈΡΡΡΠΏΡΠ½ΡΠ°ΡΠ° ΡΠ΅ΠΌΠ°ΡΠ΅ΡΠ°ΡΡΡ Π³Π°ΡΡΡΠΎΡ Π²ΠΎΠ΄ΠΎΡ ΠΎΡΠΈΡΠ΅Π½ΠΎΡ, ΡΠΎ Π΄Π°Ρ ΠΌΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ Π²ΠΈΡΡΠ³Π½ΡΡΠΈ ΠΏΠΎΠ½Π°Π΄ 70 % ΡΡΠΌΠΈ ΡΠ»Π°Π²ΠΎΠ½ΠΎΡΠ΄ΡΠ² ΡΠ· ΠΏΠΎΡΠ°ΡΠΊΠΎΠ²ΠΎΡ ΡΠΈΡΠΎΠ²ΠΈΠ½ΠΈ. ΠΠ»Ρ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠ°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π΄ΠΎΠΏΠΎΠΌΡΠΆΠ½ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡΠ² ΠΏΠ»ΡΠ²ΠΊΠΎΠ²ΠΎΡ ΠΌΠ°ΡΡΠΈΡΡ ΠΏΡΠΈΠ³ΠΎΡΡΠ²Π°Π»ΠΈ ΠΊΡΠ»ΡΠΊΠ° ΡΡΠ·Π½ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡΠΉ, ΡΠΎ Π²ΠΊΠ»ΡΡΠ°ΡΡΡ Π½Π°ΡΡΡΡ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»ΡΠ»ΠΎΠ·Ρ, ΠΆΠ΅Π»Π°ΡΠΈΠ½, ΠΏΠΎΠ»ΡΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄-600, ΡΡΠΈΠΌΠ΅ΠΊΠ°ΡΠ½, Π½Π°ΡΡΡΡ Π±Π΅Π½Π·ΠΎΠ°Ρ Ρ Π²ΠΎΠ΄Π½Π΅ Π²ΠΈΡΡΠ³Π°Π½Π½Ρ Π· ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ. ΠΡΡΠΈΠΌΠ°Π½Ρ ΠΏΠ»ΡΠ²ΠΊΠΈ Π±ΡΠ»ΠΈ Π³Π½ΡΡΠΊΠΈΠΌΠΈ, ΠΏΡΡΠΆΠ½ΠΈΠΌΠΈ ΠΏΠ»Π°ΡΡΠΈΠ½Π°ΠΌΠΈ ΡΠ²ΡΡΠ»ΠΎ-ΠΊΠΎΡΠΈΡΠ½Π΅Π²ΠΎΠ³ΠΎ ΠΊΠΎΠ»ΡΠΎΡΡ Π· ΠΏΡΠΈΡΠΌΠ½ΠΈΠΌ ΡΠΏΠ΅ΡΠΈΡΡΡΠ½ΠΈΠΌ Π·Π°ΠΏΠ°Ρ
ΠΎΠΌ Ρ ΡΠΌΠ°ΠΊΠΎΠΌ, ΡΠΎΒ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΈΠΉ Π΄Π»Ρ ΠΎΡΠ³Π°Π½ΠΎΠ»Π΅ΠΏΡΠΈΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ. Π£ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΡΡΠ²Π½ΡΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ Π°Π΄Π³Π΅Π·ΡΠΉΠ½ΠΎΡ, ΠΎΡΠΌΠΎΡΠΈΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ° Π±ΡΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
Π·ΡΠ°Π·ΠΊΡΠ² ΠΏΠ»ΡΠ²ΠΎΠΊ Π²ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ: Π½Π°ΠΉΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡΠΈΠΉ ΡΠΊΠ»Π°Π΄ ΡΡΡΡ Π»ΡΠΊΠ°ΡΡΡΠΊΠΎΡ ΡΠΎΡΠΌΠΈ Π²ΠΊΠ»ΡΡΠ°Ρ 0,2 Π³ ΡΡΠΈΠΌΠ΅ΠΊΠ°ΡΠ½Ρ; 2,0 Π³ Π½Π°ΡΡΡΡ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π»ΡΠ»ΠΎΠ·ΠΈ; 2,0 Π³ ΠΆΠ΅Π»Π°ΡΠΈΠ½Ρ; 2,0 Π³ ΠΏΠΎΠ»ΡΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠΊΡΠΈΠ΄Ρ-600; 0,01 Π³ Π½Π°ΡΡΡΡ Π±Π΅Π½Π·ΠΎΠ°ΡΡ ΡΠ° Π²ΠΎΠ΄Π½Π΅ Π²ΠΈΡΡΠ³Π°Π½Π½Ρ Π· ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ Π΄ΠΎ 100,0 Π³.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΈΠΉ ΡΠΊΠ»Π°Π΄ Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ Π΄ΠΈΡΡΡΠΈΡ
ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΠ»ΡΠ²ΠΎΠΊ Π°Π½Π΅ΡΡΠ΅Π·ΡΠ²Π°Π»ΡΠ½ΠΎΡ ΡΠ° ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π΄ΡΡ, ΠΊΠΎΡΡΡ ΠΌΡΡΡΡΡΡ ΡΡΠΈΠΌΠ΅ΠΊΠ°ΡΠ½ Ρ Π²ΠΎΠ΄Π½Π΅ Π²ΠΈΡΡΠ³Π°Π½Π½Ρ Π· ΠΊΠ²ΡΡΠΎΠΊ ΡΠΎΠΌΠ°ΡΠΊΠΈ
Development of composition and technology of children's dental films with anesthetic and anti-inflammatory activity
The work purpose. To develop composition and technology of children's dental films with anesthetic and anti-inflammatory activity.
Materials and methods. Pharmaceutical substance of trimecaine, Chamomile flowers and excipients: sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, purified water were used in the study. These were permitted for medical use and meet the requirements of the relevant regulatory documents. Aqueous extract from Chamomile flowers was obtained in laboratory conditions with method of remaceration in compliance with rules of technology for this method. The content of flavonoids in terms of rutin in flowers of Chamomile and the resulting aqueous extracts was determined with spectrophotometria by Pharmacopoeias method. Film-forming solutions were prepared in accordance with their physico-chemical properties and recommended technological modes of preparation. The dental films were obtained by the method of watering the film mass on a glass substrate, followed by drying. In order to select the optimal composition of dental films we investigated their adhesive properties, osmotic activity and biopharmaceutical performance. The adhesion activity of dental films was studied by the method, based on the determination of the strength of separation the glass plates from each other. The osmotic activity of dental films was determined by method of dialysis through a semipermeable membrane. The biopharmaceutical properties were evaluated by the method of diffusion in agar.
Results. It was found that the most appropriate way to obtain an aqueous extract of Chamomile flowers is a three-stage remaceration of hot purified water, which allows to extract more than 70 % of the amount of flavonoids from the feedstock. To determine the rational combination of auxiliary components of film matrix several different compositions, comprising sodium carboxymethylcellulose, gelatin, polyethylene oxide-600, trimecaine, sodium benzoate, and aqueous extract of chamomile flowers were prepared. The resulting films were a flexible elastic plates light brown color with a pleasant characteristic odor and taste characteristic for organoleptic properties of Chamomile flowers. As a result of the comparative study of adhesive and osmotic activity and of biopharmaceutical properties of experimental films of samples, we found that the optimal composition of the dosage form comprises 0.2 g trimecaine; 2.0 g of sodium carboxymethylcellulose; 2.0 g of gelatin; 2.0 g of polyethylene oxide-600; 0.01 g of sodium benzoate and aqueous extract of Chamomile flowers to 100.0 g.
Conclusions. Was developed the composition and technology of dental films with anesthetic and anti-inflammatory action, to be used in children, containing trimecaine and aqueous extract of Chamomile flowers
DEVELOPMENT OF TECHNOLOGY FOR DRY EXTRACT OF GRASS HARROW THE FIELD
The urgency of developing a drug laxative action of grass harrow the field in the form of dry extract. The technologyΒ of dry extract of grass harrow using the method of vacuum filtration of extraction. A quantification of the active ingredients βΒ phenolic compounds of a dry extract of grass harrow causing its laxative effect. The total content of phenolic compoundsΒ (isoflavones, flavonoids, phenolcarbonic acids) in phytopreparations harrow was about 25 %
Development method for quantitative determination of thymoquinone in seeds nigella sativa
The technique of quantitative determination of thymoquinone black cumin seeds sown by the method of capillary electrophoresis. Held its validation parameters: specificity, linearity, accuracy and precision. Electrophoretic technique can be used for valuation and assessment of quality of raw materials blackie by active ingredient - thymoquinone
THE FEASIBILITY AND POSSIBLE WAYS COMPLEX PROCESSING OF FRUITS SOPHORA JAPONICA
The fruits of Sophora japonica has long been successfully used as an antiseptic. However, despite the long period of application, the range of medicines produced from the fruit of Sophora japonica, has not changed and is still limited. One way to solve this problem is to implement a comprehensive recycling Sophora fruit. In this regard, the purpose was to study the possibilities of studies of complex processing them by the fruit of Sophora sequential extraction with extractants bipolar and antimicrobial activity of the resulting fractions with biologically active substances. It revealed that most rational for bipolar fractions of fruit of Sophora - potential drugs extractants use is as follows: 95% ethyl alcohol, 70% ethyl alcohol, purified water
Method of surgical treatment of the central hernias of an intervertebral disk on a lumbar level
In given article the new method of treatment of the central hernias of a lumbar level of a backbone in comparison with other methods forward and back decompression spinal canal is described. Indications and contrindications to the specified method, advantages and lacks of existing methods of treatment of stenoses vertebral channel