Results on a pedagogic approach for tailoring public health interventions to minimise opportunistic infections.

We are performing curriculum modifications on the first year BSc (Hons) Biomedical Science module “Basic Microbiology” (De Montfort University, UK) to increase students’ knowledge of basic medical parasitology and infectious diseases, so these students can acquire the necessary skills to tackle their final degree module “Medical Microbiology”. Following student feedback on a novel short intervention in 2017/18 to promote awareness about human immunodeficiency virus (HIV), we have created an engaging workshop session to cover not only HIV but also the opportunistic infections that can affect HIV patients that have developed acquired immune deficiency syndrome (AIDS) and how to prevent them. The objective of this work was to evaluate the effectiveness of the improved workshop developed and to collect students’ impressions to perform further modifications if needed. Briefly, students were required to develop public health measures for HIV positive patients with two different degrees of immunosuppression (i.e. with CD4+ T cells in peripheral blood above and below 200 cells/μl) to prevent exposure and infection from opportunistic pathogens such as Cryptosporidium spp., Toxoplasma gondii or Pneumocystis jirovecii from: a) sexual exposures; b) intravenous drug use; b) environment and work; c) food and water; d) foreign travel. Students, following evidence-based public health methodology, tailored their measures or interventions using the most up-to-date information reported in the literature regarding HIV chemoprophylaxis and recent guidelines published by US Department of Health and Human Services on HIV/AIDS treatment and prevention. Interventions were critically analysed with all students in the last 20 min. of the workshop, which was repeated several times due to the number of students (n=203). The objectives of this workshop were evaluated by careful analysis of a specific feedback questionnaire (n=46 out of 203) voluntarily completed by students at the end of the workshop. The questionnaire showed the following feedback: 80.4% (65.2% agreed; 15.2% strongly agreed) indicated that they learnt how to identify public health interventions; and 95.7% (56.5% agreed; 39.1% strongly agreed) indicated that they would be able to establish measures to reduce HIV transmission and prevent opportunistic infections. Additionally, 95.7% (39.1% agreed; 56.5% strongly agreed) indicated that the workshop helped them to understand the relevance of local and global interventions. Finally, 97.8% of responders considered that the content (52.2% agreed; 45.7% strongly agreed) and duration (60.9% agreed; 37% strongly agreed) of the workshop was appropriate; and 89.1% (58.7% agreed; 30.4% strongly agreed) and 73.9% (41.3% agreed; 32.6% strongly agreed) enjoyed and were satisfied with the workshop provided, respectively. In conclusion, the improved workshop developed would seem to be effective for promoting sexual and public health education to minimise opportunistic pathogen infections in relevant patients when delivered to students with a basic knowledge of microbiology and parasitology

Errors on the inverse problem solution for a noisy spherical gravitational wave antenna

A single spherical antenna is capable of measuring the direction and polarization of a gravitational wave. It is possible to solve the inverse problem using only linear algebra even in the presence of noise. The simplicity of this solution enables one to explore the error on the solution using standard techniques. In this paper we derive the error on the direction and polarization measurements of a gravitational wave. We show that the solid angle error and the uncertainty on the wave amplitude are direction independent. We also discuss the possibility of determining the polarization amplitudes with isotropic sensitivity for any given gravitational wave source.Comment: 13 pages, 4 figures, LaTeX2e, IOP style, submitted to CQ

Evidence for Antipodal Hot Spots During X-ray Bursts From 4U 1636-536

The discovery of high-frequency brightness oscillations in thermonuclear X-ray bursts from several neutron-star low-mass X-ray binaries has important implications for the beat frequency model of kilohertz quasi-periodic brightness oscillations, the propagation of nuclear burning, the structure of the subsurface magnetic fields in neutron stars, and the equation of state of high-density matter. These implications depend crucially on whether the observed frequency is the stellar spin frequency or its first overtone. Here we report an analysis of five bursts from 4U 1636-536 which exhibit strong oscillations at approximately 580 Hz. We show that combining the data from the first 0.75 seconds of each of the five bursts yields a signal at 290 Hz that is significant at the $4\times 10^{-5}$ level when the number of trials is taken into account. This strongly indicates that 290 Hz is the spin frequency of this neutron star and that 580 Hz is its first overtone, in agreement with other arguments about this source but in contrast to suggestions in the literature that 580 Hz is the true spin frequency. The method used here, which is an algorithm for combining time series data from the five bursts so that the phases of the 580 Hz oscillations are aligned, may be used in any source to search for weak oscillations that have frequencies related in a definite way to the frequency of a strong oscillation.Comment: 9 pages including one figure, uses aaspp4.sty, submitted to The Astrophysical Journal Letters on September 1

Evolving wormhole geometries within nonlinear electrodynamics

In this work, we explore the possibility of evolving (2+1) and (3+1)-dimensional wormhole spacetimes, conformally related to the respective static geometries, within the context of nonlinear electrodynamics. For the (3+1)-dimensional spacetime, it is found that the Einstein field equation imposes a contracting wormhole solution and the obedience of the weak energy condition. Nevertheless, in the presence of an electric field, the latter presents a singularity at the throat, however, for a pure magnetic field the solution is regular. For the (2+1)-dimensional case, it is also found that the physical fields are singular at the throat. Thus, taking into account the principle of finiteness, which states that a satisfactory theory should avoid physical quantities becoming infinite, one may rule out evolving (3+1)-dimensional wormhole solutions, in the presence of an electric field, and the (2+1)-dimensional case coupled to nonlinear electrodynamics.Comment: 17 pages, 1 figure; to appear in Classical and Quantum Gravity. V2: minor corrections, including a referenc

Deconvolving the information from an imperfect spherical gravitational wave antenna

We have studied the effects of imperfections in spherical gravitational wave antenna on our ability to properly interpret the data it will produce. The results of a numerical simulation are reported that quantitatively describe the systematic errors resulting from imperfections in various components of the antenna. In addition, the results of measurements on a room-temperature prototype are presented that verify it is possible to accurately deconvolve the data in practice.Comment: 5 pages, 2 figures, to be published in Europhysics Letter

Security policy refinement using data integration: a position paper.

In spite of the wide adoption of policy-based approaches for security management, and many existing treatments of policy verification and analysis, relatively little attention has been paid to policy refinement: the problem of deriving lower-level, runnable policies from higher-level policies, policy goals, and specifications. In this paper we present our initial ideas on this task, using and adapting concepts from data integration. We take a view of policies as governing the performance of an action on a target by a subject, possibly with certain conditions. Transformation rules are applied to these components of a policy in a structured way, in order to translate the policy into more refined terms; the transformation rules we use are similar to those of global-as-view database schema mappings, or to extensions thereof. We illustrate our ideas with an example. Copyright 2009 ACM